Ipriflavone 200 mg Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking Ipriflavone 200 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ipriflavone 200 mg is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,111 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Ipriflavone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ipriflavone 200 mg by Solgar
Ask about any prescription or over-the-counter medication and we check it for interactions with Ipriflavone 200 mg by Solgar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ipriflavone 200 mg by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: ipriflavone, a compound similar to plant isoflavones that your body processes to support bone health. The remaining ingredients—microcrystalline cellulose, vegetable cellulose, and vegetable magnesium stearate—are inactive fillers and capsule material.
Does it work?
Strong evidence
Ipriflavone is rated likely effective for osteoporosis and likely effective for Paget disease (an abnormal bone-remodeling condition). The evidence supports its use for these bone-related conditions based on the data we hold.
How safe is it?
Well-documented data
Orally, ipriflavone is generally well tolerated, though some people report epigastric pain (discomfort in the upper belly), diarrhea, and dizziness. There's a caution about possible low white blood cell counts (lymphocytopenia) if you take it for at least 6 months, and the long-term safety data is limited.
Ipriflavone is not recommended in pregnancy due to insufficient safety data and possible estrogen-like effects, and it should be avoided during breastfeeding because reliable safety information isn't available.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before starting ipriflavone if you take theophylline (a breathing medication)—ipriflavone can raise its levels. Also flag any drugs metabolized by liver enzymes CYP1A2 or CYP2C9 (including muscle relaxants, some antidepressants, and anti-anxiety medications) and any immunosuppressant drugs, as these carry Moderate interaction risks.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Ipriflavone may be worth considering if you have osteoporosis or Paget disease, but it has significant interactions with common medications metabolized by your liver and with theophylline. It's not appropriate in pregnancy or breastfeeding.
Talk with your doctor or pharmacist about whether this product fits your situation and whether your current medications are safe to combine with it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ipriflavone 200 mg, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984014640 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 26, 2020 |
| DSLD ID | 214586 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ipriflavone 200 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 2 Gram(s) | 1% |
| Dietary Fiber | 1 Gram(s) | 3% |
| Ipriflavone | 200 mg | -- |
Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Solgar's Ipriflavone Vegetable Capsules are free of corn, yeast, wheat, soy and dairy products and are formulated without the use of artificial preservatives, flavors or colors.
Suitable for vegetarians
Sugar, salt and starch free
Storage
To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.
Formula
Solgar's KOF-K certification #K-1250
Precautions
Do not use if outer bottle seal is missing, torn or damaged in any way.
Use only as directed.
If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Keep out of reach of children.
General Statements
Solgar since 1947
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
K Parve (Kosher)
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take one (1) vegetable capsule three times daily, preferably at mealtimes, or as directed by a healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ipriflavone 200 mg by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ipriflavone 200 mg by Solgar
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsIpriflavone
Interacts with391 drugs
Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably preven...
Ipriflavone monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Ipriflavone 200 mg by Solgar Drug Interactions
HelloPharmacist Interaction Report
Ipriflavone by Solgar can interact with medications, primarily through its effect on how your liver breaks down certain drugs.
The most serious concern is with theophylline (a breathing medication), where ipriflavone can raise theophylline levels in your blood to potentially unsafe amounts—this is a Moderate severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Ipriflavone also inhibits two major liver enzymes (CYP1A2 and CYP2C9) that clear many common medications. This means drugs metabolized by these pathways—including some antidepressants, muscle relaxants, anti-anxiety medications, and others—may build up in your system and cause toxicity.
These are all Moderate severity interactions.
There's an additional Moderate concern with immunosuppressant drugs (used after transplants or for severe autoimmune conditions): ipriflavone may add to their immune-suppressing effects, and some people taking ipriflavone develop low white blood cell counts. Altogether, these interactions span 391 individual medications.
Before you start ipriflavone, run your exact medications through the search tool on this page or ask your doctor or pharmacist to check them against this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ipriflavone 200 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ipriflavone 200 mg interact with 2,111 drugs. Click any drug to see the details.
2 of the 2 ingredients in Ipriflavone 200 mg interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Ipriflavone
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneImmunosuppressants Moderate
Interaction Summary
Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function.
Read the full Ipriflavone + 6-mercaptopurine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 2c9 (cyp2c9) Substrates, Immunosuppressants Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9).
Read the full Ipriflavone + Abrocitinib interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abrocitinib interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Aspirin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Aspirin, Caffeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Butalbital interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Butalbital, Caffeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Butalbital, Caffeine, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Butalbital, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Butalbital, Codeine Phosphate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Caffeine, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Caffeine, Codeine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Caffeine, Dihydrocodeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Caffeine, Isometheptene interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Caffeine, Pyrilamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Ipriflavone 200 mg — through 2 ingredients. Tap an ingredient for the detail:
IpriflavoneCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ipriflavone 200 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Ipriflavone
Cytochrome P450 1A2 (Cyp1A2) Substrates
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.
Immunosuppressants
Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia; avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
Theophylline
Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone. Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme.
Brand information
Manufacturer and brand details for Ipriflavone 200 mg, from the product label.
Solgar
See all Solgar products- Name
- Solgar Vitamin and Herb
- City
- Leonia
- State
- N.J.
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
Ipriflavone 200 mg by Solgar: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ipriflavone 200 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographIpriflavone
Interacts with 391 drugsIpriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Beca...
Read the full Ipriflavone monograph →Sources & How We Checked
Ipriflavone 200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Ipriflavone 6 references
- Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
- Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
- Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
- Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
- Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
- Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC