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Dietary supplement

Iso Lean 3 Extreme Ingredients & Drug Interactions

by Advanced Nutrition Systems

Iso Lean 3 Extreme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Iso Lean 3 Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Iso Lean 3 Extreme is a dietary supplement by Advanced Nutrition Systems with 3 active ingredients.Based on those ingredients, 1,699 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Iso Lean 3 Extreme by Advanced Nutrition Systems

Ask about any prescription or over-the-counter medication and we check it for interactions with Iso Lean 3 Extreme by Advanced Nutrition Systems — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Iso Lean 3 Extreme by Advanced Nutrition Systems

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 15 active ingredients.
  • “Thermogenic Delivery System” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “ISO Metabolic Enhancer Neuro Focus Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Hydro Cut Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Iso Lean 3 Extreme contains 15 active and inactive ingredients designed for energy and weight management. The two caffeine sources—caffeine anhydrous and dicaffeine malate—deliver stimulant effects for mental alertness and athletic performance.

Phosphatidylserine is included to support cognitive function. Additional active botanicals include yohimbine (from yohimbe bark), theacrine (TeaCrine), green tea extract, ashwagandha root extract, garcinia fruit rind extract, and extracts of juniper, dandelion, huperzia serrata (toothed clubmoss), uva ursi, and buchu.

The product also contains blended proprietary formulations: a thermogenic delivery system, a neuro-focus blend, a hydro-cut blend, and an iso lean blend. Inactive ingredients are gelatin (capsule), di-calcium phosphate, nonfat dry milk, titanium dioxide, silicon dioxide, and the colorants FD&C Red #40 and FD&C Blue #1.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Thermogenic energy metabolism and appetite support.
  • We looked for evidence on: Athletic performance, Fatigue, Cognitive function, Weight management, Metabolic rate, Mental alertness — and 1 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Yohimbe is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Fatigue.

Evidence for this product's individual ingredients is mixed. Caffeine is effective for neonatal apnea and postoperative headaches, and likely effective for mental alertness and athletic performance.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease, though evidence for athletic performance, ADHD, cognitive function, and dementia is insufficient. Theacrine's effectiveness for athletic performance, mental alertness, fatigue, cognitive function, and muscle strength is not established in our data.

Green tea is likely effective for human papillomavirus-related conditions and possibly effective for ovarian cancer and high cholesterol. Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder.

The effectiveness of yohimbine, garcinia, and the botanical extracts for their intended uses—weight loss, fat burning, diuresis—is either insufficient or not rated in the data we hold. Overall, only caffeine and green tea have strong evidence; most others lack established proof of benefit.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 11 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate amounts is generally well tolerated in healthy adults, but high doses can cause anxiety, insomnia, tremors, nausea, diarrhea, gastric irritation, and rarely stroke. Pregnant women should limit caffeine intake due to possible risks, though some data suggest it may be safe in small amounts; breastfeeding mothers should know small amounts pass into breast milk.

Phosphatidylserine is generally well tolerated but long-term safety is not fully established; it should be avoided in pregnancy and while breastfeeding due to insufficient data. Yohimbine can cause serious heart and blood pressure effects and should be avoided entirely during pregnancy and breastfeeding.

Theacrine appears generally well tolerated short-term but lacks long-term safety data; it should be avoided in pregnancy and breastfeeding. Green tea is generally safe as a beverage but concentrated extracts in high doses have caused rare liver injury; pregnant women should limit caffeine and avoid high-dose extracts, and breastfeeding mothers should moderate caffeine intake.

Ashwagandha is generally well tolerated short-term but should be avoided in pregnancy (traditionally thought to risk miscarriage) and breastfeeding. Garcinia is generally tolerated short-term, though rare reports of liver injury exist; avoid during pregnancy and breastfeeding.

The botanical extracts—juniper, dandelion, uva ursi, huperzia, and buchu—carry warnings against pregnancy use due to potential uterine effects or insufficient safety data, and most lack breastfeeding data.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 12 of the 12 matched ingredients can interact with medications — Toothed Clubmoss, Buchu, Uva Ursi, Dandelion, Juniper, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,700 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Iso Lean 3 Extreme, double-check if you use ephedrine or ephedrine-containing products (Major risk of serious stimulant effects), monoamine oxidase inhibitors or MAOIs (Major risk with yohimbine), nadolol or other beta blockers (Major risk with green tea), or atorvastatin and other statins (Major risk with green tea). Also confirm you're not on seizure medications like phenobarbital or carbamazepine, blood pressure medications, clozapine, cimetidine, fluoroquinolone antibiotics, tricyclic antidepressants, diabetes medications, blood thinners, lithium, or diuretics—all of which carry documented Moderate interactions with one or more ingredients.

If you're unsure whether your medications are affected, use the checker on this page or ask your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is designed for people seeking energy, mental focus, and weight management support through multiple stimulant and botanical ingredients. It's not appropriate for anyone taking ephedrine, MAOIs, seizure medications, blood pressure drugs, beta blockers, statins, clozapine, or diabetes medications without checking with their healthcare provider first—and the interaction list is long.

Pregnant and breastfeeding women should avoid it. Talk with your doctor or pharmacist before starting, especially if you take any prescription medications, have high blood pressure or heart conditions, or are pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 13 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Iso Lean 3 Extreme, straight from the product label.

Brand Advanced Nutrition Systems
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 180540
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Iso Lean 3 Extreme by Advanced Nutrition Systems, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Medium Chain Triglycerides0 NP--
Caffeine Anhydrous285 mg--
Phosphatidyl Serine0 NP--
Dicaffeine Malate0 NP--
Yohimbine HCl0 NP--
TeaCrine Theacrine0 NP--
Rutaecarpine0 NP--
Thermogenic Delivery System0 NP--
ISO Metabolic Enhancer Neuro Focus Blend0 NP--
Hydro Cut Blend0 NP--
Juniper (Juniperus communis) extract0 NP--
Dandelion (Taraxacum officinale) extract0 NP--
Iso Lean 3 Blend639 mg--
Green Tea (Camelia sinensis) leaf extract0 NP--
KSM-66 Ashwagandha (Withania somnifera) root extract0 NP--
Garcinia cambogia (fruit rind) extract0 NP--
Huperzia serrata (whole herb) extract0 NP--
Uva Ursi (Arctostaphylos uva-ursi) extract0 NP--
Buchu extract0 NP--

Other ingredients: Gelatin, Di-Calcium Phosphate, nonfat dry Milk, Titanium Dioxide, Silicon Dioxide, FD&C Red #40, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Iso Lean 3 All bodies are not created equal Developed to be the most potent thermogenic available, providing explosive energy, intense focus, enhanced diuretic support and a superior metabolism boost.

Thermogenic

Metabolism Energy Appetite

Please recycle.

Proudly made in the USA with carefully selected ingredients of international and domestic origin.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 capsule with 8 oz of water. Do not take more than 1 capsule daily. This product should not be taken in combination with other products containing caffeine or other stimulants. Do not take within six hours of bedtime. Please read the entire label before use.

Precautions

Do not take more than 1 capsule daily. This product should not be taken in combination with other products containing caffeine or other stimulants. Do not take within six hours of bedtime. Please read the entire label before use.

Contains: Soy, Milk

Produced in a facility that also uses milk, eggs, fish, shellfish, treenuts, peanuts, wheat and soy.

Warning: Do not use if pregnant, nursing, or plan on becoming pregnant.

This product is intended for use by healthy adults over the age of 18 and should be avoided by those sensitive to caffeine or other ingredients that have known stimulant effects. Contains caffeine.

Do not use this product continuously for more than 8 weeks. Do not combine with alcohol. Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake.

Do not consume caffeine from other sources, including, but not limited to coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine. Consult a physician or licensed qualified health care professional prior to use if you are pregnant or nursing, or if you are taking medication, including, but not limited to MAOI, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants, or if you have a medical condition, including, but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if safety seal under cap is broken.

Keep out of reach of children.

Formula

Contains: Soy, Milk

Contains caffeine.

Brand IP Statement(s)

KSM-66 is a registered trademark of Ixoreal Biomed Private Limited. TeaCrine is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc.

Storage

Store in a cool, dry place.

Seals/Symbols

Made in the USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Iso Lean 3 Extreme by Advanced Nutrition Systems label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Iso Lean 3 Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Iso Lean 3 Extreme by Advanced Nutrition Systems

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Iso Lean 3 Blend

639 mg per serving
  • › Thermogenic Delivery System
  • › ISO Metabolic Enhancer Neuro Focus Blend
  • › Hydro Cut Blend

Other (inactive) ingredients: Gelatin, Di-Calcium Phosphate, Nonfat dry Milk, Titanium Dioxide, Silicon Dioxide, FD&C Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Iso Lean 3 Extreme by Advanced Nutrition Systems Drug Interactions

Want to check YOUR meds against Iso Lean 3 Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,699Drugs
22 Major 1,676 Moderate 1 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Iso Lean 3 Extreme interact with 1,699 drugs. Click any drug to see the details.

0 of the 3 ingredients in Iso Lean 3 Extreme interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Iso Lean 3 Extreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Iso Lean 3 Extreme, from the product label.

Advanced Nutrition Systems

See all Advanced Nutrition Systems products
Name
Advanced Nutrition Systems
Pharmacist Counseling Corner

Iso Lean 3 Extreme by Advanced Nutrition Systems: Common Questions

Does Iso Lean 3 Extreme by Advanced Nutrition Systems interact with any medications?
Yes. Based on its ingredients, Iso Lean 3 Extreme has a known interaction with 1,699 medications, including 22 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Iso Lean 3 Extreme contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No. Yohimbine should be avoided entirely in pregnancy, and while caffeine and green tea may be possibly safe in limited amounts, this product's high stimulant load and use of botanicals like juniper and uva ursi that are traditionally thought to affect the uterus make it unsafe overall. Talk with your doctor before using any supplement during pregnancy.
Can I take this while breastfeeding?
The safety data are insufficient or advise against it for most ingredients. Caffeine and green tea pass into breast milk in small amounts that may be acceptable at moderate doses, but yohimbine should be avoided, and the other botanicals lack breastfeeding safety data. Discuss this with your doctor or pharmacist before using it.
What's the caffeine content, and could it make me jittery?
The product contains two caffeine sources—caffeine anhydrous and dicaffeine malate—but the exact dose per serving is not provided in the product facts. Yes, caffeine commonly causes jitteriness, anxiety, insomnia, tremors, and restlessness, especially at high doses or if you're sensitive. Start with the lowest dose and see how you feel.
Does this product actually help with weight loss?
The effectiveness of garcinia, yohimbine, and the botanical ingredients for weight loss or fat burning is either insufficient or not rated in our data. Caffeine is likely effective for athletic performance, but that's not the same as weight loss. Don't rely on this product alone for weight management.
Is this safe for people with high blood pressure?
No. Multiple ingredients—caffeine, yohimbine, and green tea—can raise blood pressure, and if you're on blood pressure medication, several ingredients may reduce its effectiveness. Avoid this product if you have high blood pressure or take blood pressure drugs unless your doctor explicitly approves it.
What are the most common side effects I might experience?
Caffeine can cause anxiety, insomnia, tremors, nausea, diarrhea, and gastric irritation. Yohimbine may cause anxiety, agitation, sweating, flushing, and increased urination. Phosphatidylserine can cause flatulence, nausea, and headache. Ashwagandha may cause drowsiness, diarrhea, or gastrointestinal upset. Start with a low dose to assess tolerance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Iso Lean 3 Extreme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Iso Lean 3 Extreme label
Sources

Sources & How We Checked

Iso Lean 3 Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 655 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  6. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  7. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  8. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  9. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
  10. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
  11. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
  12. The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
  13. Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. PubMed
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  16. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
  17. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. PubMed
  18. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed
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  21. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed
  22. Tobias JD. Caffeine in the treatment of apnea associated with respiratory syncytial virus infection in neonates and infants. South Med J 2000;93:297-304. DOI
  23. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
  24. Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. PubMed
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  26. Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9.
  27. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. PubMed
  28. Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. PubMed
  29. Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. DOI
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  32. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. PubMed
  33. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. PubMed
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  35. McGowan JD, Altman RE, Kanto WP Jr. Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. South Med J 1988;81:1092-4.. PubMed
  36. Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. PubMed
  37. Dreher HM. The effect of caffeine reduction on sleep quality and well-being in persons with HIV. J Psychosom Res 2003;54:191-8.. PubMed
  38. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  39. Schechter MD, Timmons GD. Objectively measured hyperactivity--II. Caffeine and amphetamine effects. J Clin Pharmacol 1985;25:276-80.. PubMed
  40. Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183. DOI
  41. Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. PubMed
  42. Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. PubMed
  43. Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. PubMed
  44. May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. PubMed
  45. Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8. PubMed
  46. Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. PubMed
  47. Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. DOI
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  49. Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. PubMed
  50. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  51. Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. PubMed
  52. Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7.
  53. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI
  54. Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. PubMed
  55. Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70. PubMed
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Ashwagandha 32 references
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Garcinia 44 references
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Toothed Clubmoss 3 references
  1. Budavari S, ed. The Merck Index. 12th ed. Whitehouse Station, NJ: Merck & Co., Inc., 1996.
  2. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
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See these in context on the Toothed Clubmoss monograph →

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
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See these in context on the Uva Ursi monograph →

Buchu 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  3. Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.

See these in context on the Buchu monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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