Interactions on record — worth a quick check against your medications. Based on 5 of 15 ingredients. Check your meds →
Dietary supplement

Isomer E 268.4 mg (400 IU) Ingredients & Drug Interactions

by GNC

Isomer E 268.4 mg (400 IU) label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Isomer E 268.4 mg (400 IU) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Isomer E 268.4 mg (400 IU) is a dietary supplement by GNC with 15 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 828 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Cranberry seed Oil, Red Raspberry seed oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Isomer E 268.4 mg (400 IU) by GNC

Ask about any prescription or over-the-counter medication and we check it for interactions with Isomer E 268.4 mg (400 IU) by GNC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Isomer E 268.4 mg (400 IU) by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 15 active ingredients.
  • “Toco-Rich” is listed as a grouped ingredient — the label gives one combined amount (133 mg) without saying how much of each component you get.

This product contains 15 ingredients, with multiple forms of vitamin E as the primary actives: Vitamin E, D-Alpha-Tocopherol, D-Gamma Tocotrienol, D-Alpha-Tocotrienol, D-Delta-Tocotrienol, D-Gamma-Tocopherol, D-Delta-Tocopherol, D-Beta Tocopherol, D-Beta Tocotrienol, and Total Tocopherols together deliver the 400 IU dose. Supporting ingredients include Rice Bran Oil and concentrate, Palm Oil, Cranberry seed Oil, and Red Raspberry seed oil.

The remaining ingredients—Gelatin, Glycerin, Soybean Oil, Titanium Dioxide, and Chlorophyll—are inactive excipients (fillers and capsule materials).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Antioxidant support with all 8 forms vitamin E.
  • We looked for evidence on: Age-related macular degeneration (AMD), Aging skin, Atherosclerosis, Atopic dermatitis (eczema), Cataracts, Cardiovascular disease (CVD) — and 4 related terms.
  • The strongest evidence on file: Rice Bran is rated "Possibly Effective" for Dyslipidemia (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Effective" for Exercise-induced muscle damage.
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Age-related macular degeneration (AMD), Atherosclerosis, Cataracts, Atopic dermatitis (eczema).

Vitamin E in this product is effective for treating vitamin E deficiency and a rare genetic condition called Ataxia with vitamin E deficiency (AVED). It's possibly effective for Alzheimer disease, Beta-thalassemia, Glucose-6-phosphate dehydrogenase (G6PD) deficiency, and Intracranial hemorrhage, though the evidence is less clear.

Rice bran oil is possibly effective for high cholesterol (dyslipidemia). Red raspberry and cranberry in this product have insufficient evidence or unclear effectiveness ratings for the conditions they're often marketed for.

The evidence, ingredient by ingredient Vitamin E Rice Bran Palm Oil Cranberry Red Raspberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at usual dietary amounts, but high-dose long-term supplements like this one may raise the risk of bleeding, hemorrhagic stroke, and other serious effects. The data advises against high-dose supplements in pregnancy—use only amounts from food and prenatal vitamins unless your doctor directs otherwise.

Before taking high-dose supplements while breastfeeding, check with your doctor first. Rice bran may cause digestive upset (stomach discomfort, gas, irregular bowel movements), especially when you first increase intake, and in rare cases can trigger allergic reactions.

Cranberry and red raspberry are generally well tolerated but have limited safety data at supplement doses.

Side effects, ingredient by ingredient Vitamin E Rice Bran Palm Oil Cranberry Red Raspberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Red Raspberry, Vitamin E, Cranberry, Palm Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 829 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check these medication types with your pharmacist: blood thinners and antiplatelet drugs (Major bleeding risk), warfarin in particular, chemotherapy drugs (alkylating agents and antitumor antibiotics), drugs broken down by your liver (CYP3A4 substrates like certain heart and cholesterol medications), atorvastatin (Lipitor), nifedipine (Procardia), and insulin. If you take selumetinib (Koselugo), do not combine it with this supplement without your oncologist's approval.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Consider this product if you have a diagnosed vitamin E deficiency and your doctor recommends it. Be very cautious if you take blood thinners, antiplatelet drugs, warfarin, chemotherapy, or drugs metabolized by your liver—check with your pharmacist first.

This is a high-dose vitamin E supplement, so talk to your pharmacist or doctor before adding it to your routine, especially if you're on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 15 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Isomer E 268.4 mg (400 IU), straight from the product label.

Brand GNC
Barcode (UPC) 048107177751
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 224635
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Isomer E 268.4 mg (400 IU) by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
048107177751
IngredientAmount% DV
Vitamin E268.4 mg1789%
Rice Bran Oil0 NP--
Palm Oil0 NP--
D-Alpha-Tocopherol0 NP--
Cranberry seed Oil0 NP--
D-Gamma Tocotrienol0 NP--
D-Alpha-Tocotrienol0 NP--
D-Delta-Tocotrienol0 NP--
D-Gamma-Tocopherol0 NP--
D-Delta-Tocopherol0 NP--
Rice Bran concentrate0 NP--
D-Beta Tocopherol0 NP--
D-Beta Tocotrienol0 NP--
Total Tocopherols391 mg--
Toco-Rich133 mg--
Red Raspberry seed oil0 NP--

Other ingredients: Gelatin, Glycerin, Soybean Oil, Titanium Dioxide, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Formulation

Provides 100% more antioxidant capacity than natural vitamin E

Potency verified by current USP. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

No sugar, no artificial flavors, no preservatives, sodium free, no wheat, gluten free, no corn, no dairy. GF Gluten free

Formula

Supplies all 8 types of tocopherols & tocotrienols

General Statements

90-day supply

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule daily.

Brand IP Statement(s)

Isomer E is a registered trademark of Futurebiotics, LLC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Isomer E 268.4 mg (400 IU) by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Isomer E 268.4 mg (400 IU) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Isomer E 268.4 mg (400 IU) by GNC

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
268.4 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Total Tocopherols

Interacts with
764 drugs
391 mg per serving Form: D-Alpha-Tocopherol, D-Beta Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Total Tocopherols monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Soybean Oil, Titanium Dioxide, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

Isomer E 268.4 mg (400 IU) by GNC Drug Interactions

Want to check YOUR meds against Isomer E 268.4 mg (400 IU)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
828Drugs
776 Moderate 52 Minor

Ingredients driving the most interactions

Vitamin E 764
Cranberry seed Oil 712
Red Raspberry seed oil 135
Palm Oil 122

Individual Drug Interactions

The ingredients in Isomer E 268.4 mg (400 IU) interact with 828 drugs. Click any drug to see the details.

4 of the 15 ingredients in Isomer E 268.4 mg (400 IU) interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Cranberry seed Oil Red Raspberry seed oil Palm Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Isomer E 268.4 mg (400 IU) with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Cranberry seed Oil6 drug types · 712 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
Cranberry seed Oil full monograph & interactions

Red Raspberry seed oil2 drug types · 135 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that red raspberry leaf extract has antiplatelet activity and enhances the in vitro effects of the antiplatelet medication cangrelor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Insulin

Red raspberry leaf might reduce glucose levels in patients being treated with insulin.
In one case report, a 38-year-old patient with gestational diabetes, whose blood glucose was being controlled with medical nutrition therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea daily for 3 days beginning at 32 weeks' gestation. The patient required an insulin dose reduction. The hypoglycemia was considered to be probably related to use of red raspberry leaf tea.

Likelihood Possible Evidence D
Red Raspberry seed oil full monograph & interactions

Palm Oil1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
The palm olein constituent in palm oil seems to increase platelet aggregation.

Likelihood Possible Evidence B
Palm Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Isomer E 268.4 mg (400 IU), from the product label.

GNC

See all GNC products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Isomer E 268.4 mg (400 IU) by GNC: Common Questions

Does Isomer E 268.4 mg (400 IU) by GNC interact with any medications?
Yes. Based on its ingredients, Isomer E 268.4 mg (400 IU) has a known interaction with 828 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Isomer E 268.4 mg (400 IU) contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The safety data advises against high-dose vitamin E supplements in pregnancy—stick to amounts from food and prenatal vitamins unless your doctor says otherwise. Breastfeeding is similar: normal food amounts are fine, but check with your doctor before taking high-dose supplements. Rice bran and cranberry are likely safe in food amounts during pregnancy and lactation.
Can this help with my cholesterol?
Rice bran oil in this product is possibly effective for high cholesterol, but the evidence isn't strong. Vitamin E itself doesn't have a clear cholesterol benefit in the data we hold. Talk to your doctor about proven options if that's your main goal.
What are the most common side effects?
Vitamin E at this dose is generally well tolerated. Rice bran may cause stomach discomfort, gas, or irregular bowel movements, especially at first. Cranberry and red raspberry can cause diarrhea or mild GI upset. Serious effects like bleeding are rare but possible at high doses, especially with blood-thinning drugs.
Does this product have any fillers?
Yes. The inactive ingredients are Gelatin, Glycerin, Soybean Oil, Titanium Dioxide, and Chlorophyll—these are the capsule material and binders.
How much vitamin E is in each capsule, and is that a lot?
Each softgel contains 268.4 mg, which equals 400 IU of vitamin E. That's above the upper safe limit for long-term daily use in some age groups, so it's important to use it only as directed and check with your doctor or pharmacist, especially if you take blood thinners or other medications.
Will this interact with my heart or diabetes medication?
Possibly. Vitamin E can affect how your liver breaks down certain heart and cholesterol drugs. Red raspberry oil might lower blood sugar if you're on insulin. Cranberry may increase levels of some medications. Use the checker on this page to look up your specific drugs, and talk to your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Isomer E 268.4 mg (400 IU) label
Go deeper

The Full Monographs Behind Isomer E 268.4 mg (400 IU)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Rice Bran

Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most...

Read the full Rice Bran monograph → Herb & supplement monograph

Palm Oil

Interacts with 122 drugs

Palm oil is a widely used edible oil pressed from the fruit of the oil palm tree, and red palm oil is a notable source of vitamin A and vitamin E compounds called tocotrienols. As a food it...

Read the full Palm Oil monograph → Herb & supplement monograph

Cranberry

Interacts with 712 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph → Herb & supplement monograph

Red Raspberry

Interacts with 135 drugs

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific evidence for these uses is limited. It is gene...

Read the full Red Raspberry monograph →
Sources

Sources & How We Checked

Isomer E 268.4 mg (400 IU)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 124 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
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Rice Bran 7 references
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Palm Oil 12 references
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Cranberry 33 references
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Red Raspberry 8 references
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  2. Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
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  7. Dudzinska D, Bednarska K, Boncler M, Luzak B, Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433-9.
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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