Kidney Aid Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Kidney Aid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Kidney Aid is a dietary supplement by RidgeCrest Herbals with 5 active ingredients. Its ingredients are commonly taken for fluid retention (mild diuretic), urinary and bladder concerns, hair, skin, and nail support.Based on those ingredients, 423 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fenugreek, Horsetail, European Goldenrod. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Kidney Aid by RidgeCrest Herbals
Ask about any prescription or over-the-counter medication and we check it for interactions with Kidney Aid by RidgeCrest Herbals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Kidney Aid by RidgeCrest Herbals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Kidney Aid contains 5 active ingredients: horsetail, fenugreek, hydrangea, European goldenrod, and common plantain. Horsetail is traditionally used as a diuretic; fenugreek seed is used for blood sugar and sexual function support; hydrangea and goldenrod are also recognized for potential diuretic properties; and common plantain rounds out the blend.
The inactive ingredients are gelatin, cellulose, water, stearic acid, and magnesium stearate.
Does it work?
Insufficient evidence
The evidence for these ingredients is limited. Horsetail shows insufficient reliable evidence for urinary incontinence, obesity, tonsillitis, and hair loss.
Fenugreek is possibly effective for sexual dysfunction, sexual arousal, dysmenorrhea, and diabetes. Hydrangea and goldenrod have no effectiveness ratings in our data.
For most of the uses this product implies—kidney support, kidney stones, or urinary tract health—the ingredients either have not been well studied or lack a clear evidence base.
How safe is it?
Well-documented data
Horsetail is generally well tolerated short-term in healthy adults, but long-term use carries real risks. Crude horsetail contains thiaminase, which can deplete thiamine (vitamin B1) with prolonged use—though Canadian products must be certified free of thiaminase activity.
Common side effects include abdominal distension, increased bowel movements, and nausea. The safety data advises against horsetail in pregnancy and while breastfeeding.
Fenugreek is generally well tolerated in food amounts but supplement doses may cause abdominal pain, bloating, diarrhea, flatulence, and nausea; rare severe allergic reactions (angioedema, bronchospasm, shock) have been reported. The safety data advises against medicinal fenugreek in pregnancy, though limited evidence suggests it may be safe while breastfeeding.
Hydrangea and goldenrod have limited human safety data; large or prolonged doses may cause gastroenteritis, dizziness, or chest tightness (hydrangea), and both should be avoided in pregnancy and while breastfeeding due to insufficient data.
Meds to double-check
Moderate interaction found
Before taking Kidney Aid, check with your doctor or pharmacist if you take antidiabetes drugs (horsetail and fenugreek may lower blood sugar further), diuretic drugs (horsetail and goldenrod may worsen potassium loss), lithium (horsetail and hydrangea may raise lithium levels), blood thinners or antiplatelet drugs like warfarin or clopidogrel (fenugreek may increase bleeding risk), or HIV medications including NRTIs and efavirenz (horsetail may reduce their effectiveness). Also check if you take theophylline, phenytoin, sildenafil, or metoprolol—fenugreek may reduce how well these work.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Kidney Aid is a multi-ingredient herbal blend with limited evidence for its intended uses and a number of moderate medication interactions you need to check before starting. If you take antidiabetes drugs, diuretics, lithium, HIV medications, blood thinners, theophylline, phenytoin, sildenafil, or metoprolol, run this product through the interaction checker below and talk with your doctor or pharmacist—some of these combinations could reduce drug effectiveness or raise harmful side effects.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Kidney Aid, straight from the product label.
| Brand | RidgeCrest Herbals |
|---|---|
| Barcode (UPC) | 355724001698 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2014 |
| DSLD ID | 32958 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Kidney Aid by RidgeCrest Herbals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Horsetail | 0 NP | -- |
| Fenugreek | 0 NP | -- |
| Propretary Blend | 400 mg | -- |
| Hydrangea | 0 NP | -- |
| European Goldenrod | 0 NP | -- |
| Common Plantain | 0 NP | -- |
Other ingredients: Gelatin, Cellulose, Water, Stearic Acid, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
KidneyAid is a unique herbal formula designed to help maintain healthy kidneys. Herbs have been used successfully for hundreds of years in Asia.
Suggested/Recommended/Usage/Directions
Directions: Take one or two capsules three times daily between meals.
FDA Statement of Identity
Herbal Supplement
Precautions
DO NOT USE IF TAMPER RESISTANT SEAL IS BROKEN
General
4055947
Seals/Symbols
RidgeCrest HERBALS(R)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Kidney Aid by RidgeCrest Herbals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Kidney Aid by RidgeCrest Herbals
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Propretary Blend
- › Horsetail
- › Fenugreek
- › Hydrangea
- › European Goldenrod
- › Common Plantain
Other (inactive) ingredients: Gelatin, Cellulose, Water, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Kidney Aid by RidgeCrest Herbals Drug Interactions
HelloPharmacist Interaction Report
Kidney Aid by RidgeCrest Herbals interacts with medications through its horsetail, fenugreek, hydrangea, and goldenrod content.
The most serious interactions are Moderate in severity. Horsetail raises concerns with antidiabetes drugs (risk of low blood sugar), diuretic drugs (risk of potassium loss), lithium (increased lithium levels), and HIV medications including NRTIs and efavirenz (reduced antiviral effectiveness).
Fenugreek adds similar risks with antidiabetes drugs and diuretics, plus interactions with blood thinners and antiplatelet drugs, theophylline, metoprolol, phenytoin, and sildenafil—all Moderate severity. Hydrangea and goldenrod each interact with diuretics and lithium, also Moderate.
Read the full breakdown — every affected drug type, severity by severity
Additionally, fenugreek can reduce how well certain drugs work: theophylline levels may drop by up to 28%, phenytoin by 44%, and sildenafil by up to 27%. Fenugreek may also increase the blood-thinning effect of warfarin and clopidogrel, and amplify blood pressure drops with metoprolol.
Horsetail's diuretic action mirrors these concerns with potassium-depleting diuretics and lithium.
We could not check common plantain for interactions—our data doesn't hold a safety monograph for it. Altogether, these interactions span 423 individual medications.
Use the interaction checker on this page to search your exact medications before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Kidney Aid?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Kidney Aid interact with 423 drugs. Click any drug to see the details.
4 of the 5 ingredients in Kidney Aid interact with drugs. Each result below shows which ingredient is responsible. Fenugreek Horsetail European Goldenrod Hydrangea
Abacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
HorsetailNucleoside Reverse Transcriptase Inhibitors (nrtis) Moderate
Interaction Summary
Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
Read the full Horsetail + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
HorsetailNucleoside Reverse Transcriptase Inhibitors (nrtis) Moderate
Interaction Summary
Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
Read the full Horsetail + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
FenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Acarbose interactionHorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
European GoldenrodDiuretic Drugs Moderate
Interaction Summary
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
Read the full European Goldenrod + Acetaminophen, Caffeine, Pyrilamine interactionHorsetailDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Horsetail + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
European GoldenrodDiuretic Drugs Moderate
Interaction Summary
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
Read the full European Goldenrod + Acetaminophen, Pamabrom, Pyrilamine interactionHorsetailDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Horsetail + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Kidney Aid — through 3 ingredients. Tap an ingredient for the detail:
HorsetailDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Horsetail + Acetazolamide interactionEuropean GoldenrodDiuretic Drugs Moderate
Interaction Summary
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
Read the full European Goldenrod + Acetazolamide interactionFenugreekAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
HorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Acetohexamide interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Acetylsalicylic Acid interactionAdefovirHepsera
How Adefovir interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
HorsetailNucleoside Reverse Transcriptase Inhibitors (nrtis) Moderate
Interaction Summary
Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
Read the full Horsetail + Adefovir interactionAlbiglutideTanzeum
How Albiglutide interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
HorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Albiglutide interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
FenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Alogliptin interactionHorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
HorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Alogliptin, Metformin interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
FenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Alogliptin, Pioglitazone interactionHorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Kidney Aid — through 3 ingredients. Tap an ingredient for the detail:
European GoldenrodDiuretic Drugs Moderate
Interaction Summary
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
Read the full European Goldenrod + Amiloride, Hydrochlorothiazide interactionHorsetailDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Horsetail + Amiloride, Hydrochlorothiazide interactionFenugreekAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Kidney Aid — through 3 ingredients. Tap an ingredient for the detail:
HorsetailDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Horsetail + Ammonium Chloride interactionEuropean GoldenrodDiuretic Drugs Moderate
Interaction Summary
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
Read the full European Goldenrod + Ammonium Chloride interactionFenugreekAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Kidney Aid — through 2 ingredients. Tap an ingredient for the detail:
HorsetailAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Horsetail + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionFenugreekAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Kidney Aid — through 1 ingredient. Tap an ingredient for the detail:
FenugreekAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek + Apixaban interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Kidney Aid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Fenugreek
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Horsetail
Antidiabetes Drugs
Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.
Diuretic Drugs
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.
Efavirenz (Sustiva)
Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.
Lithium
Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)
Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.
European Goldenrod
Diuretic Drugs
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
In vitro and animal research suggests that goldenrod has diuretic effects.
Hydrangea
Lithium
Hydrangea is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, hydrangea might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Kidney Aid, from the product label.
RidgeCrest Herbals
See all RidgeCrest Herbals products- Name
- RidgeCrest Herbals(R)
- Street Address
- 1151 S. Redwood Road, Suite 106
- City
- Salt Lake City
- State
- Utah
- ZipCode
- 84104
- Web Address
- www.ridgecrestherbals.com
Kidney Aid by RidgeCrest Herbals: Common Questions
Does Kidney Aid by RidgeCrest Herbals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take if I'm pregnant or breastfeeding?
Does horsetail actually help with kidney or urinary issues?
What side effects might I experience?
Can I take this long-term?
Does fenugreek work for sexual function?
What is common plantain in this blend for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Kidney Aid’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Horsetail
Interacts with 188 drugsHorsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...
Read the full Horsetail monograph → Herb & supplement monographFenugreek
Interacts with 389 drugsFenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...
Read the full Fenugreek monograph → Herb & supplement monographHydrangea
Interacts with 1 drugHydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Beca...
Read the full Hydrangea monograph → Herb & supplement monographGoldenrod
Interacts with 75 drugsGoldenrod is a flowering plant traditionally used as an herbal diuretic and for urinary tract health. Human evidence is limited, and while it is generally well tolerated, people with certain...
Read the full Goldenrod monograph →Sources & How We Checked
Kidney Aid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 51 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Horsetail 14 references
- Sudan BJ. Seborrhoeic dermatitis induced by nicotine of horsetails (Equisetum arvense L.). Contact Dermatitis 1985;13:201-2.
- Perez Gutierrez RM, Laguna GY, Walkowski A. Diuretic activity of Mexican equisetum. J Ethnopharmacol 1985;14:269-72. PubMed
- Lemus I, Garcia R, Erazo S, et al. Diuretic activity of an Equisetum bogotense tea (Platero herb): evaluation in healthy volunteers. J Ethnopharmacol 1996;54:55-8. PubMed
- Revilla MC, Andrade-Cetto A, Islas S, Wiedenfeld H. Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients. J Ethnopharmacol 2002;81:117-20. PubMed
- Tiktinskii, O. L. and Bablumian, I. A. [Therapeutic action of Java tea and field horsetail in uric acid diathesis]. Urol.Nefrol.(Mosk) 1983;3(1):47-50.
- Henderson JA, Evans EV, and McIntosh RA. The antithiamine action of Equisetum. J Amer Vet Med Assoc 1952;120:375-378.
- Carneiro DM, Freire RC, Honório TC, Zoghaib I, Cardoso FF, Tresvenzol LM, de Paula JR, Sousa AL, Jardim PC, da Cunha LC. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Voluntee
- Klnçalp S, Ekiz F, Basar Ö, Coban S, Yüksel O. Equisetum arvense (Field Horsetail)-induced liver injury. Eur J Gastroenterol Hepatol. 2012 Feb;24(2):213-4. PubMed
- Ortega García JA, Angulo MG, Sobrino-Najul EJ, Soldin OP, Mira AP, Martínez-Salcedo E, Claudio L. Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report. J Med Case Rep. 2011 M PubMed
- Cordova E, Morganti L, Rodriguez C. Possible Drug-Herb Interaction between Herbal Supplement Containing Horsetail (Equisetum arvense) and Antiretroviral Drugs. J Int Assoc Provid AIDS Care. 2017;16(1):11-13.
- García Gavilán MD, Moreno García AM, Rosales Zabal JM, Navarro Jarabo JM, Sánchez Cantos A. Case of drug-induced acute pancreatitis produced by horsetail infusions. Rev Esp Enferm Dig. 2017 Apr;109(4):301-304. PubMed
- Vieira GT, de Oliveira TT, Carneiro MAA, et al. Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. PubMed
- Health Canada. Organism-Equisetum arvense. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq.do?id=6117&lang=eng. Accessed 21-July 2021.
- Bates D, Duong TB, Kheyson S, Moore K. Hyponatremia Secondary to Decreased Oral Intake and SIADH and Possibly Exacerbated by Horsetail (Equisetum arvense). Can J Hosp Pharm 2021;74(4):386-389. PubMed
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
- Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
- Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
- Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed
- Mora, A., Herrrera, A., Lopez, C., Dahbi, G., Mamani, R., Pita, J. M., Alonso, M. P., Llovo, J., Bernardez, M. I., Blanco, J. E., Blanco, M., and Blanco, J. Characteristics of the Shiga-toxin-producing enteroaggregative Escherichia coli O104:H4 German ou
- Blanco, J. [Stx2a-producing enteroaggregative Escherichia coli O104:H4-ST678. Microbiological diagnostic already, for this and other STEC/VTEC serotypes!]. Enferm.Infecc.Microbiol.Clin. 2012;30(2):84-89.
- Beutin, L. and Martin, A. Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains. J Food Prot. 2012;75(2):408-418. PubMed
- King LA, Nogareda F, Weill FX, Mariani-Kurkdjian P, Loukiadis E, Gault G, Jourdan-DaSilva N, Bingen E, Macé M, Thevenot D, Ong N, Castor C, Noël H, Van Cauteren D, Charron M, Vaillant V, Aldabe B, Goulet V, Delmas G, Couturier E, Le Strat Y, Combe C, Delm
- Reeder C, Legrand A, O'Connor-Von SK. The Effect of Fenugreek on Milk Production and Prolactin Levels in Mothers of Preterm Infants. Clinical Lactation 2013;4(4):159-165. DOI
- Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Pharm Biol 2015;53(2):296-300. PubMed
- Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a doubl
- Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011 Sep;25(9):1294-300.
- Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol. 2016 Dec 24;194:260-268. PubMed
- Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed
- Khodamoradi K, Khosropanah MH, Ayati Z, et al. The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-analysis. Complement Ther Med. 2020;52:102416. PubMed
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
- Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.
Hydrangea 1 reference
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Goldenrod 6 references
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Uter, W., Nohle, M., Randerath, B., and Schwanitz, H. J. Occupational contact urticaria and late-phase bronchial asthma caused by compositae pollen in a florist. Am J Contact Dermat. 2001;12(3):182-184. DOI
- Chodera, A., Dabrowska, K., Sloderbach, A., Skrzypczak, L., and Budzianowski, J. [Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes]. Acta Pol.Pharm 1991;48(5-6):35-37.
- Chodera, A., Dabrowska, K., Bobkiewicz-Kozlowska, T., Tkaczyk, J., Skrzypczak, L., and Budzianowski, J. [Effect of leiocarposide on experimental urinary calculi in rats]. Acta Pol.Pharm 1988;45(2):181-186.
- Chodera, A., Dabrowska, K., Skrzypczak, L., and Budzianowski, J. [Further studies on the diuretic effect of leiocarposide]. Acta Pol.Pharm 1986;43(5):499-503.
- Chodera, A., Dabrowska, K., Senczuk, M., Wasik-Olejnik, A., Skrzypczak, L., Budzianowski, J., and Ellnain-Wojtaszek, M. [Diuretic effect of the glycoside from a plant of the Solidago L. genus]. Acta Pol.Pharm 1985;42(2):199-204.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC