Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Klean Endurance Ingredients & Drug Interactions

by Klean Athlete

Klean Endurance label
See full label image
Tablet Or Pill Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Klean Endurance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Klean Endurance is a dietary supplement by Klean Athlete with 2 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Klean Endurance by Klean Athlete

Ask about any prescription or over-the-counter medication and we check it for interactions with Klean Endurance by Klean Athlete — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Klean Endurance by Klean Athlete

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Klean Endurance has one active ingredient: D-ribose, a simple sugar that your body uses as fuel during and after exercise. The tablet also contains inactive ingredients — xylitol, cellulose, hydroxypropylcellulose, natural orange and vanilla flavors, citric acid, mannitol, vegetable stearate, stearic acid, natural palm wax, and silica — which are fillers, binders, and flavorings.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: energy and athletic performance support.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Coronary heart disease (CHD) — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-ribose on athletic performance is rated possibly ineffective, meaning it hasn't shown solid benefit in research. For muscle soreness, congestive heart failure (heart muscle weakness), restless legs syndrome, and recovery from heart bypass surgery, we don't have enough reliable data to say whether it works.

McArdle disease, a rare muscle disorder, also shows possibly ineffective evidence.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-ribose is generally well tolerated short-term — usually up to one month — but long-term safety isn't well studied. The most common side effects are diarrhea, gastrointestinal discomfort, headache, and nausea; some people report lightheadedness, increased appetite, or mild anxiety, though lowering the dose can resolve these.

Because ribose lowers blood sugar, it's a particular concern if you have diabetes or take diabetes medications. There isn't enough safety data on D-ribose in pregnancy or while breastfeeding, so the safety data advises against it during both periods.

Talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take insulin or any antidiabetes drugs (metformin, sulfonylureas, DPP-4 inhibitors, and others). Ribose can lower blood sugar, so these combinations risk a bigger dip than either alone.

Your doctor or pharmacist can review your specific drugs and whether combining them with this product is safe.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Klean Endurance may appeal to athletes looking for an energy boost, but the evidence it actually improves performance is weak. The bigger issue is its blood-sugar-lowering effect — if you take insulin or diabetes medications, you need to check with your doctor or pharmacist before starting it.

For anyone else without blood sugar concerns and without other conditions listed above, a short-term trial is generally tolerated, but don't expect a proven edge in the gym.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Klean Endurance, straight from the product label.

Brand Klean Athlete
Barcode (UPC) 310539038444
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69609
Product type Fiber And Other Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Klean Endurance by Klean Athlete, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
90
UPC/BARCODE
310539038444
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)2%
Sugar1.67 Gram(s)--
D-Ribose1.67 Gram(s)--
Sugar Alcohol0.5 Gram(s)--

Other ingredients: Xylitol, Cellulose, Hydroxypropylcellulose, natural Orange flavor, natural Vanilla flavor, Citric Acid, Mannitol, Vegetable Stearate, Stearic Acid, natural Palm Wax, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nutritional supplements

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

NSF Certified for sport

Brand IP Statement(s)

Corvalen Ribose

Protected by U.S. patents 6,159,942; 6,534,480; 6,218,366; 6,339,716; 6,703,370 and other U.S. and foreign patents issued and pending.

2008 Bioenergy, Inc.

Formulation

This product contains no salt, yeast, wheat, gluten, soy, artificial coloring, artificial preservatives or genetically modified organisms (GMOs).

Suggested/Recommended/Usage/Directions

Suggested Usage: Take one chewable tablet one to three times daily with food or as directed.

Precautions

Warning: If you are pregnant, nursing, have any health condition (especially insulin-dependent diabetics) or taking any medication, consult your health care practitioner before using this product.

Keep out of reach of children.

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #KA201245-90L V3

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Klean Endurance by Klean Athlete label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Klean Endurance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Klean Endurance by Klean Athlete

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1.67 Gram(s) per serving

D-Ribose

Interacts with
86 drugs
1.67 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Other (inactive) ingredients: Xylitol, Cellulose, Hydroxypropylcellulose, Natural Orange flavor, Natural Vanilla flavor, Citric Acid, Mannitol, Vegetable Stearate, Stearic Acid, Natural Palm Wax, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Klean Endurance by Klean Athlete Drug Interactions

Want to check YOUR meds against Klean Endurance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in Klean Endurance interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Klean Endurance interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Klean Endurance with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Klean Endurance, from the product label.

Klean Athlete

See all Klean Athlete products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.855.255.5326
Web Address
www.kleanathlete.com
Pharmacist Counseling Corner

Klean Endurance by Klean Athlete: Common Questions

Does Klean Endurance by Klean Athlete interact with any medications?
Yes. Based on its ingredients, Klean Endurance has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Klean Endurance contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me recover faster from workouts?
The evidence says probably not — D-ribose is rated possibly ineffective for athletic performance. Muscle soreness and recovery don't have enough reliable data either way, so we can't say it'll help.
What's the most common side effect?
Diarrhea, nausea, and headache show up most often in people who take ribose. Some folks also report lightheadedness or a mild anxious feeling, but lowering your dose usually clears these up.
Can I take this if I'm on diabetes medication?
Not without checking first. Ribose lowers blood sugar, so combining it with insulin or diabetes drugs raises the risk of low blood sugar (hypoglycemia). Your doctor or pharmacist needs to weigh the risks for you personally.
Is it safe during pregnancy or while breastfeeding?
There isn't enough safety data, so the information advises against it during both pregnancy and breastfeeding. Talk with your doctor or pharmacist if you're in either situation — they can discuss your options.
How long is it safe to take?
Ribose is generally well tolerated for up to one month. Long-term safety hasn't been well studied, so don't count on it being safe indefinitely without checking with your pharmacist or doctor.
What is D-ribose and what does it do?
D-ribose is a simple sugar your body uses for energy during exercise. It's meant to fuel your muscles, though the evidence it actually improves performance is weak.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Klean Endurance is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Klean Endurance label
Go deeper

The Full Monographs Behind Klean Endurance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Klean Endurance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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