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Dietary supplement

Krill Oil 1000 mg Ingredients & Drug Interactions

by Supplement Spot

Krill Oil 1000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Krill Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Krill Oil 1000 mg is a dietary supplement by Supplement Spot with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 840 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Krill Oil 1000 mg by Supplement Spot

Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Oil 1000 mg by Supplement Spot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Krill Oil 1000 mg by Supplement Spot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid)” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Krill Oil 1000 mg contains 5 active ingredients: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—the two omega-3 fatty acids your body uses—plus astaxanthin, a natural antioxidant from krill, and other naturally occurring essential fatty acids and phospholipids that come with krill oil in its whole form. The softgel capsule itself is made from gelatin, glycerin, purified water, and ethyl vanillin (for flavoring).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports cardiovascular and brain health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Heart failure, Stroke, Age-related cognitive decline — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive function, Heart failure, Hyperlipidemia, and more.

The evidence we hold rates astaxanthin's effectiveness as insufficient for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer's disease, athletic performance, and carpal tunnel syndrome. That means the studies don't yet support a clear benefit claim for those uses.

We don't hold effectiveness ratings for the other ingredients in this product, so we can't speak to what the research shows for EPA, DHA, phospholipids, or the other fatty acids on their own.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported are abdominal pain, diarrhea, and red fecal color—the red color is from the astaxanthin itself and is not harmful.

A small number of trial participants at higher doses (40 mg daily) experienced severe stomach or abdominal pain. During pregnancy, there isn't enough safety data, so it's best to avoid it.

The same goes for breastfeeding—we don't have enough information to know it's safe, so you should avoid it during that time as well.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 674 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Krill Oil 1000 mg, double-check any medications you take that are metabolized by CYP3A4 enzymes (Moderate severity)—statins, some blood pressure drugs, antihistamines, and many others fall into this category. Also check drugs broken down by CYP2B6 (Moderate severity).

Use the medication checker on this page or confirm with your own pharmacist that your specific prescriptions won't be affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Krill Oil might appeal to you if you're looking for omega-3 support and tolerate the astaxanthin it contains, but the big thing to check first is whether your medications are affected by the CYP3A4 and CYP2B6 enzyme systems—that's 672 medications total. If you take any prescription drugs, especially for blood pressure, cholesterol, immune function, or heart rhythm, run them through the search tool on this page or talk with your own doctor or pharmacist before starting.

Pregnant or breastfeeding? Avoid this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Krill Oil 1000 mg, straight from the product label.

Brand Supplement Spot
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264626
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Krill Oil 1000 mg by Supplement Spot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Eicosapentaenoic Acid0 NP--
Docosahexaenoic Acid0 NP--
Astaxanthin0 NP--
EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid)200 mg--
Krill Oil1000 mg--
other naturally-occurring essential Fatty Acids0 NP--
Phospholipids200 mg--

Other ingredients: Gelatin, Glycerin, purified Water, Ethyl Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 2 softgels taken daily preferably with meals or as directed by a healthcare professional.

Precautions

Caution: Do not exceed recommended dose. Contains desiccant packet for freshness. Do not eat packet. Do not use if safety seal is damaged or missing.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Allergen warning: Contains crustacean shellfish (krill).

Storage

Store in a cool, dry place.

Seals/Symbols

Formulated in USA Sourced from a GMP Certified Facility

Made in USA

Formulation

Supports cardiovascular and brain health

This product is PCB tested and guaranteed to be within Proposition 65 limits.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Krill Oil 1000 mg per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Krill Oil 1000 mg by Supplement Spot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Krill Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Krill Oil 1000 mg by Supplement Spot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Krill Oil

Interacts with
208 drugs
1000 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions
  • › Astaxanthin
  • › EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid)
  • › Other naturally-occurring essential Fatty Acids
  • › Phospholipids

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Ethyl Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Krill Oil 1000 mg by Supplement Spot Drug Interactions

Want to check YOUR meds against Krill Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
840Drugs
840 Moderate

Ingredients driving the most interactions

Krill Oil 208

Individual Drug Interactions

The ingredients in Krill Oil 1000 mg interact with 840 drugs. Click any drug to see the details.

1 of the 1 ingredient in Krill Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Krill Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Krill Oil 1000 mg, from the product label.

Supplement Spot

See all Supplement Spot products
Name
Supplement Spot, LLC
Street Address
1828 Touby Pike
City
Kokomo
State
IN
ZipCode
46901
Phone Number
866-285-1998
Web Address
supplementspot.com
Pharmacist Counseling Corner

Krill Oil 1000 mg by Supplement Spot: Common Questions

Does Krill Oil 1000 mg by Supplement Spot interact with any medications?
Yes. Based on its ingredients, Krill Oil 1000 mg has a known interaction with 840 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Krill Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is astaxanthin the same thing as the omega-3s in krill oil?
No. The omega-3s are EPA and DHA—fatty acids your body actually uses. Astaxanthin is a separate compound, an antioxidant that naturally comes with krill. This product has both.
Can I take this if I'm pregnant?
No, there isn't enough safety data during pregnancy, so it's best to avoid it. Talk with your doctor about other options if you're looking for omega-3 support during pregnancy.
What's the red color in my stool when I take this?
That's the astaxanthin—it's red and passes through your body, turning your stool red. It's not harmful, just a visible sign the supplement is moving through your system.
Does astaxanthin actually work for what the bottle claims?
We don't have strong evidence yet. For the uses astaxanthin is commonly marketed for—like cognitive decline, macular degeneration, and skin aging—the research is still insufficient to say it works.
What if I get stomach pain from this?
A small number of people in studies reported abdominal pain, especially at higher doses. If it happens to you, stop taking it and talk with your pharmacist—there may be a better option for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Krill Oil 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Krill Oil 1000 mg label
Go deeper

The Full Monographs Behind Krill Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 673 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Krill Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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