L-Glutamine 500 mg Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking L-Glutamine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Glutamine 500 mg is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Glutamine 500 mg by Solgar
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glutamine 500 mg by Solgar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Glutamine 500 mg by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Solgar's L-Glutamine 500 mg is a single-ingredient supplement: L-glutamine, an amino acid your body naturally makes and uses for gut health, immune function, and muscle recovery. The capsule also contains vegetable cellulose, microcrystalline cellulose, vegetable magnesium stearate, and stearic acid—standard inactive ingredients that help form and preserve the capsule.
Does it work?
Moderate evidence
The evidence behind L-glutamine varies by use. It's rated effective for sickle cell disease.
For HIV/AIDS-related wasting, postoperative recovery, and critical illness (trauma), the evidence is labeled possibly effective, meaning studies suggest it may help but the data isn't conclusive enough to be certain. The data we hold doesn't cover every possible use, so if you're considering it for something else, ask your doctor or pharmacist whether research supports it.
How safe is it?
Well-documented data
L-glutamine is generally well tolerated in healthy adults. The most common side effects are gastrointestinal: belching, bloating, constipation, flatulence, nausea, vomiting, diarrhea, and stomach pain.
Headache and musculoskeletal pain have also been reported. If you have kidney or liver disease, use it only under medical supervision.
Pregnancy and lactation are rated likely safe, but if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting it to confirm it's right for your situation.
Meds to double-check
Moderate interaction found
If you take anticonvulsant medications (seizure drugs), confirm with your doctor or pharmacist before starting this product. Theoretically, L-glutamine might reduce their effectiveness, though this hasn't been reported in people yet.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
L-glutamine may be worth considering if you have sickle cell disease or are recovering from surgery or critical illness, but the evidence for other uses is limited. If you take anticonvulsant medications, check with your doctor or pharmacist first.
It's generally well tolerated, though it can cause digestive upset in some people. Anyone with kidney or liver disease should get medical clearance before use.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Glutamine 500 mg, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984013223 |
| Net contents | 250 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2018 |
| DSLD ID | 81565 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Glutamine 500 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Glutamine | 1500 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
L-Glutamine is a major fuel source for intestinal, immune and brain cells. It also comprises nearly 60% of the body’s total free amino acid muscle pool. L-Glutamine regulates nitrogen transport to and from muscle tissue, thereby promoting amino acid balance.
Since 1947
Natural muscle food Promotes GI health
Formula
This formulation provides Free Form L-Glutamine to promote optimal absorption and assimilation.
Solgar’s KOF-K certification #K-1250
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
2016 Solgar, Inc.
General
SOLGB71320 02C
Formulation
Non-GMO Gluten, wheat & dairy free
Suitable for vegans
Free Of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.
Seals/Symbols
GF Certified Gluten-free
K Parve
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take three (3) vegetable capsules up to three times daily, between meals or as directed by a healthcare practitioner.
Precautions
If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Discontinue use and consult your healthcare practitioner if any adverse reactions occur.
Keep out of reach of children.
Do not use if outer bottle seal is missing or damaged.
Storage
Store at room temperature.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Glutamine 500 mg by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Glutamine 500 mg by Solgar
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Vegetable Capsule(s) Dosage formCapsule Servings per container83 Amounts shown are per serving.
L-Glutamine
Interacts with50 drugs
Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...
L-Glutamine monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
L-Glutamine 500 mg by Solgar Drug Interactions
HelloPharmacist Interaction Report
Solgar's L-Glutamine 500 mg has documented interactions through its L-glutamine content with anticonvulsant medications (drugs used to prevent seizures).
The concern is theoretical but worth knowing: glutamine is broken down in your body into glutamate, an excitatory brain chemical that might work against anticonvulsants. This interaction hasn't been reported in people yet, but the mechanism is plausible enough that you should confirm with your doctor or pharmacist before combining them.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 50 individual medications.
If you take anticonvulsants, run your specific medications through the interaction checker on this page before starting L-glutamine. Your healthcare provider can help you weigh the potential benefit against the theoretical risk and monitor you if needed.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Glutamine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Glutamine 500 mg interact with 50 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Glutamine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine
MephobarbitalMebaral
How Mephobarbital interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Mephobarbital interactionMethsuximideCelontin
How Methsuximide interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Methsuximide interactionOxazepamSerax
How Oxazepam interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Oxazepam interactionOxcarbazepineOxtellar XR, Trileptal
How Oxcarbazepine interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Oxcarbazepine interactionPentobarbitalNembutal
How Pentobarbital interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Pentobarbital interactionPentobarbitonePentobarbitone
How Pentobarbitone interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Pentobarbitone interactionPhenacemidePhenurone
How Phenacemide interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenacemide interactionPhenobarbitalLuminal, Phenobarbital, Solfoton
How Phenobarbital interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenobarbital interactionPhenobarbital, PhenytoinDilantin with PB
How Phenobarbital, Phenytoin interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenobarbital, Phenytoin interactionPhensuximideMilontin
How Phensuximide interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phensuximide interactionPhentermine, TopiramateQsymia
How Phentermine, Topiramate interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phentermine, Topiramate interactionPhenytoinDi-Phen, Dilantin, Dilantin Infatabs, Dilantin injection, Dilantin Kapseals, Phenytek
How Phenytoin interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Phenytoin interactionPrimidoneMysoline
How Primidone interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Primidone interactionSodium ValproateEpilim
How Sodium Valproate interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Sodium Valproate interactionTiagabineGabitril
How Tiagabine interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Tiagabine interactionTopiramateEprontia, Qudexy XR, Topamax, Trokendi XR
How Topiramate interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Topiramate interactionTrimethadioneTridione
How Trimethadione interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Trimethadione interactionValproic AcidDepacon, Depakene, Valproate
How Valproic Acid interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Valproic Acid interactionVigabatrinSabril
How Vigabatrin interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Vigabatrin interactionZonisamideZonegran, Zonisade
How Zonisamide interacts with L-Glutamine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Zonisamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Glutamine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Brand information
Manufacturer and brand details for L-Glutamine 500 mg, from the product label.
Solgar
See all Solgar products- Name
- Solgar, Inc.
- Street Address
- 500 Willow Tree Road
- City
- Leonia
- State
- NJ
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
L-Glutamine 500 mg by Solgar: Common Questions
Does L-Glutamine 500 mg by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-glutamine, and why is it in supplements?
Can I take this if I'm pregnant or breastfeeding?
What side effects should I watch for?
Does L-glutamine actually work?
I have kidney disease—can I take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Glutamine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Glutamine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Glutamine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC