L-Methionine 500 mg Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking L-Methionine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methionine 500 mg is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Methionine 500 mg by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Methionine, a naturally occurring amino acid. L-Methionine plays roles in protein synthesis, energy production, and the formation of other important compounds in your body.
The capsule also contains inactive ingredients — vegetable cellulose, silica, and vegetable magnesium stearate — which are typical binders, flow agents, and capsule materials.
Does it work?
Couldn't assess
The evidence on L-Methionine is mixed. For neural tube birth defects (like spina bifida), it's rated possibly effective — there's some research backing it, but more data would help.
For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, the evidence we have is too limited to rate it one way or the other. If you're considering this for a specific health goal, talk it over with your doctor or pharmacist about what the current science actually supports.
How safe is it?
Well-documented data
When you get L-Methionine from food, it's well tolerated and safe. In supplement doses, though, it's less certain.
The adverse effects we know about include dizziness, drowsiness, low blood pressure, irritability, vomiting, headache, and increases in homocysteine (a compound linked to heart and blood vessel problems) and urinary calcium loss. Rare serious effects include brain swelling (cerebral edema) and liver-related brain dysfunction (hepatic encephalopathy).
High doses — especially 75–100 mg per kilogram of body weight daily — are more likely to raise homocysteine. The product label advises using high-dose supplements only under medical guidance.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we checked. That said, run your medications through the interaction checker on this page before you start, and ask your pharmacist if you have any questions.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
L-Methionine is an amino acid with limited proven benefits at supplement doses. If you're pregnant or breastfeeding, the safety data on supplement doses isn't established, so talk with your doctor or pharmacist before starting.
Because of the potential to raise homocysteine (a heart risk factor), anyone with a history of heart or blood vessel disease should check with their own healthcare provider first. No drug interactions are documented, but it's still smart to confirm your exact medications with your pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methionine 500 mg, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984017542 |
| Net contents | 90 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2020 |
| DSLD ID | 218487 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methionine 500 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Methionine | 500 mg | -- |
Other ingredients: Vegetable Cellulose, Silica, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
L-Methionine is an essential amino acid that acts as an antioxidant promoter. The body is able to convert methionine to cysteine which acts as a precursor to the detoxifying antioxidant L-Glutathione. Methionine is also lipotropic, helping to support fat metabolism.
Free form Antioxidant promoter
Non-GMO Gluten, wheat & dairy free
Suitable for vegans
Free of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.
Formula
This formulation provides Free Form L-Methionine to promote optimal absorption and assimilation.
Solgar’s KOF-K certification #K-1250
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
2018 Solgar, Inc.
General Statements
Solgar since 1947
Seals/Symbols
GF Certified Gluten-free K Parve (Kosher)
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take one (1) vegetable capsule twice daily, between meals or as directed by a healthcare practitioner.
Precautions
If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Discontinue use and consult your healthcare practitioner if any adverse reactions occur.
Keep out of reach of children.
Do not use if outer bottle seal is missing or damaged.
Storage
Store at room temperature.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methionine 500 mg by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methionine 500 mg by Solgar
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Methionine 500 mg by Solgar Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Methionine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Methionine 500 mg, from the product label.
Solgar
See all Solgar products- Name
- Solgar, Inc.
- Street Address
- 500 Willow Tree Road
- City
- Leonia
- State
- NJ
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
L-Methionine 500 mg by Solgar: Common Questions
Does L-Methionine 500 mg by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-Methionine safe to take while pregnant?
Is L-Methionine safe while breastfeeding?
What side effects might I notice?
Does L-Methionine actually work for anything?
Will this raise my homocysteine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methionine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methionine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methionine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Methionine 12 references
- La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
- Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
- Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
- Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
- Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
- McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
- Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
- Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
- Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
- Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
- Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC