No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Ornithine Ingredients & Drug Interactions

by Twinlab

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Ornithine is a dietary supplement by Twinlab with 1 active ingredient. Its ingredients are commonly taken for athletic performance and recovery, reducing fatigue, sleep and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Ornithine by Twinlab

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-ornithine, an amino acid. The capsule also holds gelatin, medium chain triglycerides, magnesium stearate, and silica as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Ornithine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Ornithine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (Natural Medicines).

The evidence shows L-ornithine is possibly effective for athletic performance. For dry skin, insomnia, and periodontitis (gum inflammation), the evidence isn't strong enough to rate — we don't have reliable data saying whether it works for those uses.

The evidence, ingredient by ingredient Ornithine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Ornithine is generally well tolerated over the short term, but we don't have good information about long-term safety. The safety data advises against using it during pregnancy or while breastfeeding because there isn't enough evidence to know it's safe in those situations.

Side effects, ingredient by ingredient Ornithine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-ornithine with the medications we checked.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and some safety-information gaps remain.

If you're interested in L-ornithine for athletic performance, the evidence is modest but exists. For other uses, we don't have solid data yet.

Since long-term safety isn't well studied and pregnancy and breastfeeding safety data are limited, talk it over with your own doctor or pharmacist to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Ornithine, straight from the product label.

Brand Twinlab
Barcode (UPC) 027434001472
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 268470
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Ornithine by Twinlab, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
027434001472
IngredientAmount% DV
L-Ornithine500 mg--

Other ingredients: Gelatin, Medium Chain Triglycerides, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Well tolerated by the most highly allergic individuals.

No tablet binders, coatings or colorings. No added flavorings, salt, artificial sweeteners, preservatives or salicylates.

Twinlab L-Ornithine Capsules are easier to swallow and assimilate. Best if used by date shown on bottle.

Storage

Keep tightly closed in a cool, dry place.

Formula

Free Form Amino Acid

L-Ornithine is an amino acid.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one capsule daily or as directed by a healthcare professional. For best results, take on an empty stomach before bedtime.

See for yourself

L-Ornithine by Twinlab label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Ornithine by Twinlab

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

L-Ornithine

No known
interactions
500 mg per serving Form: L-Ornithine Hydrochloride

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

L-Ornithine monograph & interactions

Other (inactive) ingredients: Gelatin, Medium Chain Triglycerides, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Ornithine by Twinlab Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Ornithine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Ornithine, from the product label.

Twinlab

See all Twinlab products
Name
ISI Brands Inc.
City
American Fork
State
UT
ZipCode
84003
Phone Number
1-800-645-5626
Pharmacist Counseling Corner

L-Ornithine by Twinlab: Common Questions

Does L-Ornithine by Twinlab interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Ornithine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Ornithine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-ornithine actually help with athletic performance?
The evidence says it's possibly effective — meaning there's some research support, but it's not definitive. Talk with your doctor or pharmacist about whether it makes sense for your goals.
Can I take L-ornithine if I'm pregnant or breastfeeding?
The safety data advises against it because there isn't enough information to know it's safe during pregnancy or while breastfeeding. Chat with your doctor or pharmacist about your individual situation.
Is L-ornithine safe to take long-term?
It's well tolerated over the short term, but we don't have good long-term safety data. If you're thinking about taking it regularly, check in with your doctor or pharmacist first.
Will L-ornithine help my dry skin or insomnia?
The evidence isn't strong enough to say. We simply don't have reliable data on whether it works for those uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Ornithine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Ornithine label
Go deeper

The Full Monographs Behind L-Ornithine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Ornithine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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