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Dietary supplement

Lactobacillus Acidophilus Ingredients & Drug Interactions

by Pure Encapsulations

Lactobacillus Acidophilus label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lactobacillus Acidophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lactobacillus Acidophilus is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (DDS-1). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lactobacillus Acidophilus by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Lactobacillus Acidophilus by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lactobacillus Acidophilus by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Lactobacillus acidophilus (DDS-1), a beneficial bacterium that naturally lives in the human gut. It's included as a live, active culture meant to support healthy digestion and intestinal balance.

The capsule also holds two inactive ingredients — hypoallergenic plant fiber and a vegetarian capsule — that serve as fillers and the delivery vehicle.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Lactobacillus Acidophilus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Lactobacillus Acidophilus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

The evidence for Lactobacillus acidophilus is mixed. It's rated Possibly Effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis — meaning there's some promising data, but it's not definitive.

For atopic disease (allergic conditions), it's rated Possibly Ineffective. For acute respiratory distress syndrome (ARDS), we don't have enough reliable evidence yet to rate it either way.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. However, because it's a live organism, there is a theoretical risk of infection in certain patients — in rare cases, the bacteria have been found in the bloodstream or other tissues when the body's defenses are very weak.

Most of these cases involved people whose immune systems were already compromised. When taken by mouth, mild gastrointestinal side effects like bloating, gas, stomach discomfort, or diarrhea can occur, but these are uncommon.

In one trial, a probiotic combination containing L. acidophilus was linked to two cases of rash, though it's unclear whether the bacterium or another ingredient was responsible. Talk with your doctor before starting, especially if you have a weakened immune system.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your antibiotic medications with your doctor or pharmacist. Antibiotics taken at the same time as Lactobacillus acidophilus may reduce how well the probiotic works.

Spacing them out — usually several hours apart — can help avoid this interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This single-strain probiotic may be worth considering if you're dealing with IBS, antibiotic-associated diarrhea, or certain other digestive or bacterial concerns — the evidence suggests it could help, though it's not guaranteed. The main thing to watch is antibiotic timing: space them several hours apart so the antibiotics don't wipe out the live cultures before they can work.

If you're immunocompromised or have serious health concerns, check with your doctor or pharmacist first before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lactobacillus Acidophilus, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298022390
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 246182
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lactobacillus Acidophilus by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
766298022390
IngredientAmount% DV
Lactobacillus acidophilus (DDS-1)0 NP--

Other ingredients: hypoallergenic Plant Fiber, Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Refrigeration may prolong product viability.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-3 times daily, between meals.

Precautions

Warning: Probiotics may be contraindicated for immunocompromised individuals.

If you are pregnant, lactating or immunocompromised, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Formulation

Certified Gluten-free by the Gluten-Free Certification Organization, www.gluten.org

Gentle probiotic support for healthy intestinal microflora

Gluten-free, non-GMO & hypoallergenic

Gluten-free, non-GMO & hypoallergenic

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GF Gluten Free

Brand IP Statement(s)

DDS-1 is a registerd trademark of UAS Laboratories LLC and used under license.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lactobacillus Acidophilus by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lactobacillus Acidophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lactobacillus Acidophilus by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lactobacillus acidophilus (DDS-1)

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus (DDS-1) monograph & interactions

Other (inactive) ingredients: Hypoallergenic Plant Fiber, Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lactobacillus Acidophilus by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Lactobacillus Acidophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (DDS-1) 182

Individual Drug Interactions

The ingredients in Lactobacillus Acidophilus interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lactobacillus Acidophilus interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (DDS-1)

Each ingredient & the kinds of drugs it affects

For each ingredient in Lactobacillus Acidophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (DDS-1)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (DDS-1) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lactobacillus Acidophilus, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Lactobacillus Acidophilus by Pure Encapsulations: Common Questions

Does Lactobacillus Acidophilus by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Lactobacillus Acidophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lactobacillus Acidophilus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
You can take both, but timing matters. Antibiotics can kill the live organisms in this supplement, making it less effective. Your doctor or pharmacist can help you space them out — often a few hours apart works well — so they don't interfere with each other.
Is this probiotic safe if I'm pregnant?
Lactobacillus acidophilus is rated Possibly Safe in pregnancy, which means available data suggest it's likely okay, but the evidence isn't complete. Talk it over with your doctor before starting, especially if you're pregnant or planning to be.
What is Lactobacillus acidophilus, and what does it do?
It's a beneficial bacterium that naturally lives in your gut and helps maintain healthy digestion and intestinal balance. This supplement delivers live, active cultures of the DDS-1 strain to your digestive tract.
What side effects might I notice?
Most people tolerate it well. Mild bloating, gas, stomach discomfort, or diarrhea can happen, but they're uncommon. In rare cases, rashes have been reported in trials, though it wasn't clear if the probiotic was responsible.
Does this actually work for IBS or other digestive problems?
The evidence is promising but not definitive. It's rated Possibly Effective for IBS, antibiotic-associated diarrhea, Helicobacter pylori, and bacterial vaginosis — meaning some studies show benefit, but more research is needed.
Who should not take this probiotic?
If your immune system is very weak or compromised, talk with your doctor first — in rare cases, live probiotics have caused infection in immunocompromised patients. Otherwise, it's generally safe, but check with your healthcare provider about your individual situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lactobacillus Acidophilus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lactobacillus Acidophilus label
Go deeper

The Full Monographs Behind Lactobacillus Acidophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Lactobacillus Acidophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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