Major interaction on record — check this product against your medications before combining. Based on 9 of 12 ingredients. Check your meds →

Dietary supplement

Lava Orange Slush Ingredients & Drug Interactions

by Universal

See full label image

Powder Category: Other Combinations

Most serious interaction: Major

Clinical methodology reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Sep 16, 2026 · Label data from the NIH DSLD

What is this page for?

First and foremost: checking Lava Orange Slush against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Lava Orange Slush is a dietary supplement by Universal with 12 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 977 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Niacin, Magnesium, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lava Orange Slush by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with Lava Orange Slush by Universal — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds

AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI

Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Lava Orange Slush by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure

Ingredient Transparency · database check

Full

Every active ingredient lists its own amount on the label.

Why this rating?

The label discloses an exact amount for 10 of its 10 active ingredients.
No proprietary blends here — you can verify the dose of every single component.

Lava Orange Slush contains 10 active ingredients: sodium, potassium, phosphorus, creatine monohydrate, vitamin C, niacin, magnesium, taurine, chromium, and glutamine. These supply electrolytes (sodium and potassium), a phosphate source, a supplement supporting muscle energy and strength (creatine), vitamins for general health (vitamin C and niacin), minerals for bone and enzyme function (magnesium and chromium), amino acids for muscle and immune support (glutamine and taurine), and other micronutrients.

The product also contains inactive ingredients including whey proteins, a carbohydrate blend, maltodextrin, artificial flavor, citric acid, lecithin, potassium phosphate, disodium phosphate, aspartame, and carmine (a colorant).

Does it work?

Strong evidence

Evidence for Intended Use · database check

By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Constipation via Magnesium Effective
Dyspepsia via Magnesium Effective
Hypomagnesemia via Magnesium Effective
Pre-eclampsia via Magnesium Effective
Sickle cell disease via Glutamine Effective

Why this rating?

We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
On file: Constipation — rated "Effective" (Magnesium) (Natural Medicines).
On file: Dyspepsia — rated "Effective" (Magnesium) (Natural Medicines).
On file: Hypomagnesemia — rated "Effective" (Magnesium) (Natural Medicines).
On file: Pre-eclampsia — rated "Effective" (Magnesium) (Natural Medicines).
On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).

The evidence base varies widely. Creatine is possibly effective for muscle strength, athletic performance, and certain brain conditions (cerebral creatine deficiency syndromes and sarcopenia), though it is possibly ineffective for Huntington disease and osteopenia.

Vitamin C is effective for vitamin C deficiency and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections. Magnesium is effective for constipation, dyspepsia, and low magnesium (hypomagnesemia), and effective for preventing pre-eclampsia in pregnancy.

Niacin is likely effective for pellagra and possibly effective for metabolic syndrome and certain HIV-related lipid problems. Glutamine is effective for sickle cell disease and possibly effective for HIV wasting and recovery after surgery.

Taurine is possibly effective for hepatitis and congestive heart failure but possibly ineffective for obesity. Chromium is likely effective for chromium deficiency and possibly effective for diabetes, but possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

Sodium is likely effective for cystic fibrosis and possibly effective for kidney injury caused by amphotericin B, though it has insufficient evidence for heart failure and bipolar disorder. We hold no effectiveness data for potassium or phosphorus in the sources provided.

The evidence, ingredient by ingredient Sodium Potassium Creatine Vitamin C Niacin Magnesium Taurine Chromium

How safe is it?

Well-documented data

Safety Information · database check

Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?

We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
Pregnancy & breastfeeding safety ratings cover 9 of 9.
General safety write-ups exist for 9 of 9.
Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at normal dietary and supplement doses. Creatine commonly causes dehydration, diarrhea, muscle cramps, and water retention; it should be avoided in pregnancy and during breastfeeding due to lack of safety data.

Vitamin C at very high doses (above 2 grams daily) can cause kidney stones, diarrhea, and nausea; normal dietary and standard prenatal amounts are considered safe. Niacin at high supplemental doses causes flushing in up to 70% of users, gastrointestinal upset, and rarely liver damage; normal dietary amounts are safe.

Magnesium commonly causes diarrhea and gastrointestinal irritation; it is likely safe in pregnancy and possibly safe while breastfeeding but possibly unsafe at high doses during pregnancy. Taurine is likely safe in pregnancy and generally well tolerated short-term, though long-term safety is uncertain.

Sodium is essential in small amounts but excess intake is linked to high blood pressure and heart strain; avoid supplementation without medical advice. Potassium from food is safe, but supplements carry risk of dangerously high blood levels, especially in kidney disease.

Chromium and glutamine are generally well tolerated at typical doses.

Side effects, ingredient by ingredient Sodium Potassium Creatine Vitamin C Niacin Magnesium Taurine Chromium

Meds to double-check

Major interaction found

Known Interaction Concern · database check

Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?

8 of the 9 matched ingredients can interact with medications — Potassium, Glutamine, Niacin, Chromium, Magnesium, among others.
The most serious interaction on file is rated Major.
Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; cancer treatments; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
For scale: 978 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check the following medication types: Parkinson's medication (levodopa/carbidopa) — magnesium significantly reduces its effect. Blood pressure medications (antihypertensive drugs) — sodium and niacin can reduce their effectiveness, and taurine and magnesium may increase low blood pressure risk.

Blood thinners (warfarin, anticoagulants, antiplatelets) — vitamin C at high doses and niacin may interfere. Diabetes medications and insulin — chromium, niacin, and potassium may increase low blood sugar risk.

Thyroid medication (levothyroxine) — both vitamin C and chromium can affect absorption. ACE inhibitors, ARBs, and potassium-sparing diuretics — potassium in this product may raise blood potassium to unsafe levels.

Lithium — sodium and taurine can alter lithium levels. Anticonvulsants — glutamine may reduce their effect.

Heart and kidney medications — sodium and potassium may cause problems. Use the medication checker on this page to search your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient sports and electrolyte product with both established uses (creatine for muscle, magnesium for constipation, vitamin C for deficiency) and ingredients with limited or mixed evidence. The major concern is a significant interaction between magnesium and levodopa/carbidopa for Parkinson's disease—if you take that medication, do not use this product without checking with your doctor or pharmacist.

Anyone on blood pressure medication, blood thinners, diabetes drugs, thyroid replacement, heart medications, lithium, or anticonvulsants should verify their specific drugs against the interaction checker before starting. Talk with your doctor or pharmacist about whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lava Orange Slush, straight from the product label.

Brand	Universal
Barcode (UPC)	039442011527
Net contents	1.85 lbs; 841 Gram(s)
Market status	On market
Date entered into DSLD	Oct 27, 2014
DSLD ID	38226
Product type	Other Combinations
Supplement form	Powder
Dietary claims / uses	Nutrient, All Other, Structure/Function
Intended target group(s)	Adult (18 - 50 Years)

From the label

Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lava Orange Slush by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):

Adults and children 4 or more years of age

Minimum serving Sizes:

83 Gram(s)

Maximum serving Sizes:

83 Gram(s)

Servings per container

UPC/BARCODE

039442011527

Ingredient	Amount	% DV
Calories	278 {Calories}	--
Total Carbohydrates	32 Gram(s)	11%
Sugar	25 Gram(s)	--
Calories from Fat	22 {Calories}	--
Protein	32 Gram(s)	64%
Saturated Fat	1.4 Gram(s)	7%
Sodium	148 mg	6%
Potassium	339 mg	10%
Phosphorus	260 mg	26%
Total Fat	2.4 Gram(s)	4%
Creatine Monohydrate	5.5 Gram(s)	--
Vitamin C	60 mg	100%
Niacin	20 mg	100%
Magnesium	200 mg	50%
Taurine	1.2 Gram(s)	--
Chromium	75 mcg	63%
Glutamine	2.5 Gram(s)	--

Other ingredients: ultra and microfiltrated Whey Proteins, GlycoCarb Complex, Maltodextrin, Artificial flavor, Citric Acid, Lecithin, Potassium Phosphate, Disodium Phosphate, Aspartame, Carmine

Tap any ingredient to jump to its full detail below.

Label statements

These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.

Precautions

Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

INGREDIENT NOTES: Phenylketonurics: Contains Phenylalanine.

WARNING: This product is not for use by any individual under the age of 18.

Do not take this if you have or are at risk for any medical condition or disease.

Please consult with a physician before using this product, especially if your are using any prescription drug, over-the-counter medication, or supplements.

Immediately discontinue use if any side effects occur. California Residents Proposition 65 Warning: This product contains a substance known to the State of California to cause birth defects or other reproductive harm.

Keep out of reach of children.

Athletes should consult with their sanctioning authority before use.

Do not exceed recommended dose.

Formula

INGREDIENT NOTES: Phenylketonurics: Contains Phenylalanine.

Our peptide-rich whey protein contains: 45-50% Beta-Lactoglobulins (B-Lg), 15-20% Alpha-Lactalbumin (a-Lac), 15% Glycomacropeptides (GMP), 10% Immunoglobulins (IgG), 5-6% Bovine Serum Albumin (BSA), 1% Lactoferrin, 1% Lactoperoxidase, 1% Protease-Peptonese.

WHO WE ARE Universal Nutrition has been providing cutting edge and staple nutritional supplements to bodybuilders and hard training athletes the world over since 1977.

LAVA(TM) contains a sophisticated yet precise 1:1 ratio of the highest-quality carbs and proteins available. For starters, LAVA(TM) has 32g of super-premium whey protein per serving.

We’re talking the freshest ultra and micro-filtrated whey protein concentrate containing valuable microfractions.

To that we’ve added our GlycoCarb Complex(TM) which utilizes medium to high glycemic-index (GI) carbs.

We’ve also spiked LAVA(TM) with 5.5 grams of the purest creatine in the world. Now throw in a scientifically-balanced matrix composed of important amino acids like glutamine and taurine, key mineral, electrolyte and phosphate co-factors such as chromium, magnesium, sodium, potassium and phosphorous and the specialized antioxidant vitamin C and you get the most advanced nutrition formula for helping fuel muscle growth. It is simple.

Suggested/Recommended/Usage/Directions

DOSAGE: For maximum benefit, take one serving of LAVA(TM) immediately after training.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Typical Amino Acid Profile Grams of amino acids in 100g of pure protein. ESSENTIAL AMINO ACIDS L-Leucine (Branched Chain Amino Acid) 11g L-Isoleucine (Branched Chain Amino Acid) 5.8g L-Valine (Branched Chain Amino Acid) 5.3g L-Threonine 7.2g L-Lysine 9.4g L-Phenylalanine 2.7g L-Tryptophan + 1.3g L-Methionine 1.5g L-Histidine 1.2g NON-ESSENTIAL AMINO ACIDS L-Arginine ++ 1.5g L-Cysteine 2.1g L-Aspartic Acid 11.7g L-Alanine 4.9g L-Glutamic Acid 19.5g L-Glycine 1.2g L-Proline 6.2g L-Tyrosine 2.5g L-Serine 5.1g ++ Conditionally essential amino acid. The amino acids in this product are naturally occurring from the protein source. They are not added or manufactured.

MADE PROUDLY IN THE U.S.A.

Plant #3001104580

732-545-3130

As time passes, certain ideals never go out of style. Honesty. Integrity. Respect. These are the values we uphold and are the bedrock upon which we built our business. WHAT IT IS Regarding nutrition, one thing is perfectly clear: study after study reveals that strength athletes need two things: (1) carbs to fuel intense, anaerobic workouts and (2) protein to build new muscle.The perfect growth food needs to satisfy these two basic requirements. Keeping it simple.

Better quality protein means better results.

Protein is needed after exercise to kick start protein synthesis and rebuild damaged muscles.

The high-end GI carbs ensure maximum creatine and protein uptake. The medium-end GI carbs provides long lasting energy. But we didn’t leave well enough alone.

HOW WE BACK IT UP What is on the label is in the bottle and what is in the bottle will help you reach your goals. We believe it and proudly stand behind every product we manufacture. Our word is our bond.

Lean Mass Anabolic Volume Accelerator / The Perfect All-In-One Post-Workout Muscle Growth

Brand IP Statement(s)

Universal Nutrition now offers LAVA(TM).

For explosive gains, nothing compares to LAVA(TM)

FDA Statement of Identity

PWO Muscle Growth Supplement

General

E2914-G-32460

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lava Orange Slush by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)

What’s inside

The Ingredients in Lava Orange Slush by Universal

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size83 Gram(s) Dosage formPowder Servings per container10 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

25 Gram(s) per serving

Protein

32 Gram(s) per serving

Sodium

Interacts with
205 drugs

148 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs

339 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Phosphorus

260 mg per serving

Creatine Monohydrate

No known
interactions

5.5 Gram(s) per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Monohydrate monograph & interactions

Vitamin C

Interacts with
207 drugs

60 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Niacin

Interacts with
727 drugs

20 mg per serving Form: Niacinamide

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Magnesium

Interacts with
295 drugs

200 mg per serving Form: Magnesium Oxide

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Taurine

Interacts with
173 drugs

1.2 Gram(s) per serving Form: L-Taurine

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

Taurine monograph & interactions

Chromium

Interacts with
178 drugs

75 mcg per serving Form: Chromium Chloride

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Glutamine

Interacts with
50 drugs

2.5 Gram(s) per serving Form: L-Glutamine

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine monograph & interactions

Other (inactive) ingredients: Ultra and microfiltrated Whey Proteins, GlycoCarb Complex, Maltodextrin, Artificial flavor, Citric Acid, Lecithin, Potassium Phosphate, Disodium Phosphate, Aspartame, Carmine. These complete the product’s ingredient list but are not active constituents.

HelloPharmacist.com · Pharmacist card

Lava Orange Slush

by Universal · label dated Oct 27, 2014

Scan for the full live report

Known drug interactions: 977 medications — most serious rated major

Active ingredients

Sugar, Protein, Sodium, Potassium, Phosphorus, Creatine Monohydrate, Vitamin C, Niacin, Magnesium, Taurine, Chromium, Glutamine

Most serious documented interactions

Benserazide, Levodopa — Major (via Magnesium)
Carbidopa — Major (via Magnesium)
Carbidopa, Levodopa — Major (via Magnesium)

Full interaction list, ingredient monographs & live checker: https://hellopharmacist.com/drug-supplement-interactions/supplements/lava-orange-slush-by-universal-100491
Printed · Educational information only — not medical advice. Confirm against the physical product label and with your pharmacist.

Interaction report

Lava Orange Slush by Universal Drug Interactions

Lava Orange Slush — Universal · HelloPharmacist interaction report
Active ingredients: Sugar, Protein, Sodium, Potassium, Phosphorus, Creatine Monohydrate, Vitamin C, Niacin, Magnesium, Taurine, Chromium, Glutamine
Source label: Oct 27, 2014 · Printed · HelloPharmacist.com
Educational information only — not medical advice. Confirm against the physical product label and with your pharmacist.

HelloPharmacist Interaction Report

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Clinical methodology reviewed by Dr. Brian Staiger, PharmD, BCPS · Last generated Aug 13, 2026

12 active ingredients 8 with known interactions 977 medications covered

Lava Orange Slush by Universal contains several ingredients with documented medication interactions.

The most serious is a Major interaction: magnesium can significantly reduce levodopa/carbidopa absorption, lowering the medication's effectiveness by up to 35% for levodopa and 81% for carbidopa. This is critical if you take Parkinson's medication.

Read the full breakdown — every affected drug type, severity by severity

Through its sodium, potassium, vitamin C, niacin, magnesium, taurine, chromium, and glutamine content, this product interacts with Moderate-severity drug types including blood pressure medications, blood thinners, diabetes drugs, thyroid replacement, heart medications, and others. Sodium poses the broadest concern: high intake can reduce effectiveness of blood pressure drugs, increase sodium levels dangerously in patients taking certain corticosteroids or didanosine, and interact with lithium levels.

Potassium can raise blood potassium to unsafe levels when combined with ACE inhibitors, ARBs, or potassium-sparing diuretics. Vitamin C in this product can affect estrogen levels, some chemotherapy drugs, warfarin, and thyroid medication absorption.

Niacin interacts with blood pressure drugs, liver-toxic medications, blood thinners, diabetes drugs, and gout medications.

Magnesium decreases absorption of skeletal muscle relaxants, quinolone antibiotics, and bisphosphonates, and has additive effects with calcium channel blockers and blood pressure medications. Chromium may increase the risk of low blood sugar when used with diabetes drugs or insulin.

Taurine theoretically affects blood pressure medications and lithium. Glutamine may antagonize anticonvulsants.

Altogether, these interactions span 978 individual medications. We could not check phosphorus for interactions.

Use the medication checker on this page to search your exact drugs before starting this product.

Check your own medications below · Editorial policy · How we use AI

Want to check YOUR meds against Lava Orange Slush?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker

977Drugs

6 Major 940 Moderate 31 Minor

Ingredients driving the most interactions

Niacin 727

Magnesium 295

Vitamin C 207

Sodium 205

Chromium 178

Individual Drug Interactions

The ingredients in Lava Orange Slush interact with 977 drugs. Click any drug to see the details.

8 of the 12 ingredients in Lava Orange Slush interact with drugs. Each result below shows which ingredient is responsible. Niacin Magnesium Vitamin C Sodium Chromium Taurine Potassium Glutamine

All interactions 977 Major 6 Moderate 940 Minor 31

Showing 1–30 of 977 drugs.

Benserazide, LevodopaMadopar, Prolopa

Major

Benserazide, Levodopa belongs to Levodopa/carbidopa (sinemet) — the drug category that interacts with this product

How Benserazide, Levodopa interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

MagnesiumLevodopa/carbidopa (sinemet) Major

Interaction Summary

Magnesium can reduce the bioavailability of levodopa/carbidopa.

Read the full Magnesium + Benserazide, Levodopa interaction

CarbidopaLodosyn

Major

Carbidopa belongs to Levodopa/carbidopa (sinemet) — the drug category that interacts with this product

How Carbidopa interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

MagnesiumLevodopa/carbidopa (sinemet) Major

Interaction Summary

Magnesium can reduce the bioavailability of levodopa/carbidopa.

Read the full Magnesium + Carbidopa interaction

See the Carbidopa drug page: uses, dosage & side effects

Carbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR

Major

Carbidopa, Levodopa belongs to Levodopa/carbidopa (sinemet) — the drug category that interacts with this product

How Carbidopa, Levodopa interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

MagnesiumLevodopa/carbidopa (sinemet) Major

Interaction Summary

Magnesium can reduce the bioavailability of levodopa/carbidopa.

Read the full Magnesium + Carbidopa, Levodopa interaction

See the Carbidopa, Levodopa drug page: uses, dosage & side effects

Carbidopa, Levodopa, EntacaponeStalevo

Major

Carbidopa, Levodopa, Entacapone belongs to Levodopa/carbidopa (sinemet) — the drug category that interacts with this product

How Carbidopa, Levodopa, Entacapone interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

MagnesiumLevodopa/carbidopa (sinemet) Major

Interaction Summary

Magnesium can reduce the bioavailability of levodopa/carbidopa.

Read the full Magnesium + Carbidopa, Levodopa, Entacapone interaction

LevodopaInbrija, Larodopa

Major

Levodopa belongs to Levodopa/carbidopa (sinemet) — the drug category that interacts with this product

How Levodopa interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

MagnesiumLevodopa/carbidopa (sinemet) Major

Interaction Summary

Magnesium can reduce the bioavailability of levodopa/carbidopa.

Read the full Magnesium + Levodopa interaction

See the Levodopa drug page: uses, dosage & side effects

Levodopa, CarbidopaDuodopa

Major

Levodopa, Carbidopa belongs to Levodopa/carbidopa (sinemet) — the drug category that interacts with this product

How Levodopa, Carbidopa interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

MagnesiumLevodopa/carbidopa (sinemet) Major

Interaction Summary

Magnesium can reduce the bioavailability of levodopa/carbidopa.

Read the full Magnesium + Levodopa, Carbidopa interaction

6-mercaptopurinePurinethol

Moderate

6-mercaptopurine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How 6-mercaptopurine interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + 6-mercaptopurine interaction

See the 6-mercaptopurine drug page: uses, dosage & side effects

Abacavir Sulfate, Dolutegravir, LamivudineTriumeq

Moderate

Abacavir Sulfate, Dolutegravir, Lamivudine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abacavir Sulfate, Dolutegravir, Lamivudine interaction

See the Abacavir Sulfate, Dolutegravir, Lamivudine drug page: uses, dosage & side effects

Abacavir, LamivudineEpzicom

Moderate

Abacavir, Lamivudine belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Abacavir, Lamivudine interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abacavir, Lamivudine interaction

AbciximabReoPro

Moderate

Abciximab belongs to Anticoagulant/antiplatelet Drugs — the drug category that interacts with this product

How Abciximab interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Abciximab interaction

MagnesiumAnticoagulant/antiplatelet Drugs Minor

Interaction Summary

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full Magnesium + Abciximab interaction

Abiraterone

Moderate

Abiraterone belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Abiraterone interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abiraterone interaction

See the Abiraterone drug page: uses, dosage & side effects

Abiraterone AcetateYonsa, Zytiga

Moderate

Abiraterone Acetate belongs to Hepatotoxic Drugs — the drug category that interacts with this product

How Abiraterone Acetate interacts with Lava Orange Slush — through 1 ingredient. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Abiraterone Acetate interaction

See the Abiraterone Acetate drug page: uses, dosage & side effects

AbrocitinibCibinqo

Moderate

Abrocitinib belongs to Anticoagulant/antiplatelet Drugs — the drug category that interacts with this product

How Abrocitinib interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Abrocitinib interaction

MagnesiumAnticoagulant/antiplatelet Drugs Minor

Interaction Summary

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full Magnesium + Abrocitinib interaction

See the Abrocitinib drug page: uses, dosage & side effects

AcarboseGlucobay, Prandase, Precose

Moderate

Acarbose belongs to Antidiabetes DrugsHepatotoxic Drugs — the drug categories that interact with this product

How Acarbose interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinAntidiabetes Drugs, Hepatotoxic Drugs Moderate

Interaction Summary

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Niacin + Acarbose interaction

ChromiumAntidiabetes Drugs Moderate

Interaction Summary

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Read the full Chromium + Acarbose interaction

See the Acarbose drug page: uses, dosage & side effects

AcebutololRhotral, Sectral

Moderate

Acebutolol belongs to Hepatotoxic DrugsAntihypertensive Drugs — the drug categories that interact with this product

How Acebutolol interacts with Lava Orange Slush — through 3 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs, Antihypertensive Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acebutolol interaction

SodiumAntihypertensive Drugs Moderate

Interaction Summary

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full Sodium + Acebutolol interaction

TaurineAntihypertensive Drugs Moderate

Interaction Summary

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full Taurine + Acebutolol interaction

See the Acebutolol drug page: uses, dosage & side effects

AcenocoumarolSintrom

Moderate

Acenocoumarol belongs to Anticoagulant/antiplatelet Drugs — the drug category that interacts with this product

How Acenocoumarol interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Acenocoumarol interaction

MagnesiumAnticoagulant/antiplatelet Drugs Minor

Interaction Summary

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full Magnesium + Acenocoumarol interaction

AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength

Moderate

Acetaminophen belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen interaction

See the Acetaminophen drug page: uses, dosage & side effects

Acetaminophen, AspirinGemnisyn

Moderate

Acetaminophen, Aspirin belongs to Anticoagulant/antiplatelet DrugsHepatotoxic DrugsAspirinAcetaminophen (tylenol, Others)Nonsteroidal Anti-inflammatory Drugs (nsaids) — the drug categories that interact with this product

How Acetaminophen, Aspirin interacts with Lava Orange Slush — through 4 ingredients. Tap an ingredient for the detail:

NiacinAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs +1 Moderate

Interaction Summary

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full Niacin + Acetaminophen, Aspirin interaction

Vitamin CAcetaminophen (tylenol, Others), Aspirin Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Aspirin interaction

MagnesiumAnticoagulant/antiplatelet Drugs Minor

Interaction Summary

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full Magnesium + Acetaminophen, Aspirin interaction

ChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor

Interaction Summary

NSAIDs might increase chromium levels in the body.

Read the full Chromium + Acetaminophen, Aspirin interaction

Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine

Moderate

Acetaminophen, Aspirin, Caffeine belongs to AspirinAnticoagulant/antiplatelet DrugsHepatotoxic DrugsAcetaminophen (tylenol, Others)Nonsteroidal Anti-inflammatory Drugs (nsaids) — the drug categories that interact with this product

How Acetaminophen, Aspirin, Caffeine interacts with Lava Orange Slush — through 4 ingredients. Tap an ingredient for the detail:

NiacinAspirin, Anticoagulant/antiplatelet Drugs +1 Moderate

Interaction Summary

Large doses of aspirin might alter the clearance of niacin.

Read the full Niacin + Acetaminophen, Aspirin, Caffeine interaction

Vitamin CAspirin, Acetaminophen (tylenol, Others) Minor

Interaction Summary

Acidification of the urine by vitamin C might increase aspirin levels.

Read the full Vitamin C + Acetaminophen, Aspirin, Caffeine interaction

MagnesiumAnticoagulant/antiplatelet Drugs Minor

Interaction Summary

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full Magnesium + Acetaminophen, Aspirin, Caffeine interaction

ChromiumNonsteroidal Anti-inflammatory Drugs (nsaids), Aspirin Minor

Interaction Summary

NSAIDs might increase chromium levels in the body.

Read the full Chromium + Acetaminophen, Aspirin, Caffeine interaction

Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu

Moderate

Acetaminophen, Brompheniramine, Phenylpropanolamine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction

Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more

Moderate

Acetaminophen, Butalbital belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Butalbital interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Butalbital interaction

Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more

Moderate

Acetaminophen, Butalbital, Caffeine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Butalbital, Caffeine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Caffeine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Butalbital, Caffeine interaction

See the Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects

Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine

Moderate

Acetaminophen, Butalbital, Caffeine, Codeine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Caffeine, Codeine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Butalbital, Caffeine, Codeine interaction

Acetaminophen, Butalbital, CodeineBancap w/ Codeine

Moderate

Acetaminophen, Butalbital, Codeine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Butalbital, Codeine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Codeine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Butalbital, Codeine interaction

Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3

Moderate

Acetaminophen, Butalbital, Codeine Phosphate belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Butalbital, Codeine Phosphate interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Butalbital, Codeine Phosphate interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Butalbital, Codeine Phosphate interaction

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound

Moderate

Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction

Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more

Moderate

Acetaminophen, Caffeine, Codeine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Caffeine, Codeine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Codeine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Caffeine, Codeine interaction

Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3

Moderate

Acetaminophen, Caffeine, Codeine, Salicylamide belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Codeine, Salicylamide interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Caffeine, Codeine, Salicylamide interaction

Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS

Moderate

Acetaminophen, Caffeine, Dihydrocodeine belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Caffeine, Dihydrocodeine interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Dihydrocodeine interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Caffeine, Dihydrocodeine interaction

Acetaminophen, Caffeine, IsomethepteneMigralam

Moderate

Acetaminophen, Caffeine, Isometheptene belongs to Hepatotoxic DrugsAcetaminophen (tylenol, Others) — the drug categories that interact with this product

How Acetaminophen, Caffeine, Isometheptene interacts with Lava Orange Slush — through 2 ingredients. Tap an ingredient for the detail:

NiacinHepatotoxic Drugs Moderate

Interaction Summary

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full Niacin + Acetaminophen, Caffeine, Isometheptene interaction

Vitamin CAcetaminophen (tylenol, Others) Minor

Interaction Summary

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full Vitamin C + Acetaminophen, Caffeine, Isometheptene interaction

Each ingredient & the kinds of drugs it affects

For each ingredient in Lava Orange Slush with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D

Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C

Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D

Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B

Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B

Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D

Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D

Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D

Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D

Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C

Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C

Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D

Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D

Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D

Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B

Niacin full monograph & interactions

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B

Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D

Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D

Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B

Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D

Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B

Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D

Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D

Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A

Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B

Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D

Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B

Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B

Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B

Magnesium full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D

Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B

Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D

Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B

Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D

Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B

Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B

Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D

Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B

Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B

Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B

Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A

Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B

Vitamin C full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A

Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D

Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C

Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B

Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D

Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D

Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

Sodium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A

Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B

Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B

Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D

Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D

Chromium full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D

Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D

Taurine full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C

Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C

Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C

Potassium full monograph & interactions

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D

Glutamine full monograph & interactions

The maker

Brand information

Manufacturer and brand details for Lava Orange Slush, from the product label.

Universal

See all Universal products

Name: Universal Nutrition
City: New Brunswick
State: New Jersey
ZipCode: 08901
Phone Number: 800-872-0101
Web Address: www.UniversalUSA.com

Pharmacist Counseling Corner

Lava Orange Slush by Universal: Common Questions

Does Lava Orange Slush by Universal interact with any medications?

Yes. Based on its ingredients, Lava Orange Slush has a known interaction with 977 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.

How can one product interact with so many drugs?

Lava Orange Slush contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.

Where does this information come from?

The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Does creatine monohydrate really help with muscle strength and athletic performance?

Yes — research shows creatine is possibly effective for both muscle strength and athletic performance. It works by supporting muscle energy production. Common side effects include dehydration, diarrhea, muscle cramps, and water retention. If you have kidney problems, check with your doctor first.

Is this safe to take while pregnant or breastfeeding?

It depends on the ingredient. Magnesium, vitamin C at normal amounts, niacin, potassium, and taurine are likely or possibly safe in pregnancy; sodium has mixed ratings, so avoid high intake unless advised by your doctor. Creatine should be avoided in pregnancy and breastfeeding due to insufficient safety data. Always discuss supplement use with your healthcare provider during pregnancy or while nursing.

What's the sodium and potassium in this product for?

Sodium and potassium are electrolytes that regulate fluid balance, nerve signals, and muscle function. Normal dietary amounts are fine, but this product supplies supplemental amounts. If you take blood pressure medication, diabetes drugs, or diuretics, the extra sodium and potassium may cause problems — check with your doctor or pharmacist first.

Can I take this if I'm on blood pressure medication?

Not without checking first. Sodium in this product can reduce how well blood pressure medications work, and both magnesium and taurine may lower blood pressure further. Talk with your doctor or pharmacist about your specific blood pressure drugs before using this product.

Does vitamin C in this product help prevent colds?

Vitamin C is possibly effective for exercise-induced respiratory infections, not general cold prevention. The product also contains high-dose vitamin C, which at very high intakes can cause kidney stones and diarrhea — normal dietary amounts are much safer.

What's magnesium doing in a sports drink?

Magnesium supports muscle function and energy. It's effective for constipation and is needed for bone health and enzyme work. However, magnesium interacts with several medications, including Parkinson's drugs, muscle relaxants, quinolone antibiotics, and thyroid medication — so check with your doctor or pharmacist if you take any of those.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Go deeper

The Full Monographs Behind Lava Orange Slush’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →

Sources

Sources & How We Checked

Lava Orange Slush's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 420 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references

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Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Potassium 12 references

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Creatine 86 references

Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
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See these in context on the Chromium monograph →

Glutamine 11 references

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See these in context on the Glutamine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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Lava Orange Slush Ingredients & Drug Interactions

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Lava Orange Slush by Universal label

The Ingredients in Lava Orange Slush by Universal

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Lava Orange Slush by Universal Drug Interactions

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Each ingredient & the kinds of drugs it affects

Niacin15 drug types · 727 drugs

Magnesium15 drug types · 295 drugs

Vitamin C13 drug types · 207 drugs

Sodium7 drug types · 205 drugs

Chromium5 drug types · 178 drugs

Taurine2 drug types · 173 drugs

Potassium3 drug types · 62 drugs

Glutamine1 drug type · 50 drugs

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Taurine

Chromium

Glutamine

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