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Dietary supplement

Universal Glutamine Ingredients & Drug Interactions

by Universal

Universal Glutamine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Universal Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Universal Glutamine is a dietary supplement by Universal with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Universal Glutamine by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with Universal Glutamine by Universal — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Universal Glutamine by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Universal Glutamine is a single-ingredient supplement powder containing glutamine. This amino acid plays a role in muscle recovery, immune function, and gut health, and it's especially studied in situations where the body's demand for it increases—like after surgery, during critical illness, or with certain metabolic conditions.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Muscle recovery and gut health.
  • We looked for evidence on: Exercise-induced muscle damage, Athletic performance, Critical illness (trauma), Postoperative recovery, Wound healing, Oral mucositis — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma) (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Radiation-induced diarrhea.

The evidence for glutamine varies by use. It's rated effective for sickle cell disease.

For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is rated possibly effective, meaning the research shows promise but isn't yet conclusive.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine is generally well tolerated in healthy adults when taken by mouth. The most common side effects are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and stomach pain.

Headache and musculoskeletal pain have also been reported. Rare cases of dizziness, mania, and hypomania (abnormally elevated mood) have been reported in specific patient groups; dizziness resolved when the dose was lowered in one case.

People with kidney or liver disease should use glutamine only under medical supervision. There isn't enough reliable safety data for supplemental doses in pregnancy, though it's rated likely safe—talk with your doctor or pharmacist for personalized guidance.

Little safety information is available during breastfeeding, so avoid supplement doses unless your clinician advises otherwise.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (drugs that prevent seizures), check your specific medications with the search tool on this page before adding glutamine. Theoretically, glutamine might reduce how well these drugs work, though this hasn't been reported in patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Glutamine may be worth considering if you have sickle cell disease, are recovering from surgery or critical illness, or have HIV/AIDS-related wasting—especially under medical supervision. People with kidney or liver disease and anyone taking anticonvulsant medications should check with a pharmacist before starting.

If you're pregnant or breastfeeding, discuss this supplement with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Universal Glutamine, straight from the product label.

Brand Universal
Barcode (UPC) 039442046635
Net contents 1000 Gram(s)
Market status On market
Date entered into DSLD Oct 22, 2016
DSLD ID 65605
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Universal Glutamine by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
200
UPC/BARCODE
039442046635
IngredientAmount% DV
Glutamine5 Gram(s)--

Other ingredients: Glutamine, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

Warnings: Keep out of reach of children.

Before beginning any program, consult your health care practitioner.

Suggested/Recommended/Usage/Directions

Dosage: Mix 1-2 rounded teaspoonfuls in 8-12 oz. of your beverage of choice. For optimal results, try using it in your favorite protein shake or meal replacement powder.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

EAC

Made proudly in the U.S.A.

WHO WE ARE Universal Nutrition has been providing cutting edge and staple nutritional supplements to bodybuilders and hard training athletes the world over since 1977. As time passes, certain ideals never go out of style. Honesty. Integrity. Respect. These are the values we uphold and are the bedrock upon which we built our business.

Glutamine is a "conditionally" essential pro-anabolic amino acid and is the most abundant amino acid in muscle. Glutamine may be the most important variable in promoting optimum protein synthesis, while helping block cortisol to prevent protein breakdown in muscle. HOW WE BACK IT UP What is on the label is in the bottle and what is in the bottle will help you reach your goals. We believe it and proudly stand behind every product we manufacture. Our word is our bond.

100% Pure optimum cellular recovery

Brand IP Statement(s)

2015 Universal Nutrition

WHAT IT IS Glutamine Powder from Universal Nutrition provides the purest L-glutamine powder available.

FDA Statement of Identity

Dietary Supplement

Formula

Pure L- Glutamine

Finest Pharmaceutical Grade Amino Acid Full 5000mg of Glutamine Per Serving

General

A2015-G-33039

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Universal Glutamine by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Universal Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Universal Glutamine by Universal

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container200 Amounts shown are per serving.

Glutamine

Interacts with
50 drugs
5 Gram(s) per serving Form: L-Glutamine

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine monograph & interactions

Other (inactive) ingredients: Glutamine, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Universal Glutamine by Universal Drug Interactions

Want to check YOUR meds against Universal Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Glutamine 50

Individual Drug Interactions

The ingredients in Universal Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Universal Glutamine interact with drugs. Each result below shows which ingredient is responsible. Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Universal Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Universal Glutamine, from the product label.

Universal

See all Universal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.universalnutrition.com
Pharmacist Counseling Corner

Universal Glutamine by Universal: Common Questions

Does Universal Glutamine by Universal interact with any medications?
Yes. Based on its ingredients, Universal Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Universal Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects of glutamine?
Gastrointestinal side effects are most common: belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and stomach pain. Headache and muscle or joint pain have also been reported. These are usually mild, especially at lower doses.
Is glutamine safe if I'm pregnant or breastfeeding?
Glutamine is rated likely safe in pregnancy, but there isn't enough reliable safety data for supplement doses during breastfeeding. Talk with your doctor or pharmacist about whether it's right for your situation.
Who should be careful about taking glutamine?
People with kidney or liver disease should use glutamine only under medical supervision. Anyone taking anticonvulsant medications should check with a pharmacist first. Those with bipolar disorder should also discuss it with their doctor, since rare cases of mood changes have been reported.
Does glutamine actually work for sickle cell disease?
Yes—glutamine is rated effective for sickle cell disease based on the available evidence. For other uses like postoperative recovery and HIV/AIDS-related wasting, the evidence is possibly effective, meaning it shows promise but isn't yet conclusive.
What is glutamine supposed to do in my body?
Glutamine is an amino acid your body uses for muscle recovery, immune function, and gut health. Your body produces it naturally, but demand increases during surgery, serious illness, or with certain health conditions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Universal Glutamine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Universal Glutamine label
Go deeper

The Full Monographs Behind Universal Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Universal Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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