Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Left-Side Replenishing Teapills Ingredients & Drug Interactions

by Plum Flower

Tablet Or Pill Category: Botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Left-Side Replenishing Teapills is a dietary supplement by Plum Flower with 6 active ingredients. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 1,000 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lycium barbarum Fruit Extract, Rehmannia glutinosa Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Left-Side Replenishing Teapills by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,360 mg) without saying how much of each component you get.

Left-Side Replenishing Teapills contains six active ingredients: Rehmannia glutinosa root extract, Cuscuta chinensis seed extract (dodder), Lycium barbarum fruit extract (goji), Dioscorea opposita rhizome extract, Achyranthes bidentata root extract, and Cornus officinalis fruit extract. These are combined in a proprietary extract blend.

The inactive ingredients — maltose, magnesium silicate, activated charcoal, and china wax — are fillers and tablet binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Kidney and reproductive health support.
  • We looked for evidence on: Chronic kidney disease (CKD), Erectile dysfunction (ED), Diabetic nephropathy, Kidney yang deficiency, Reproductive vitality, Adrenal support.
  • The strongest evidence on file: Rehmannia is rated "Possibly Effective" for Chronic kidney disease (CKD) (Natural Medicines).
  • Also on file: Goji is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED).
  • Also on file: Rehmannia is rated "Insufficient Reliable Evidence To Rate" for Diabetic nephropathy.

The effectiveness evidence for these ingredients is sparse. Rehmannia root is possibly effective for chronic kidney disease, but evidence is insufficient to rate it for aplastic anemia, atopic disease, osteoporosis, diabetes, and diabetic nephropathy.

For Cuscuta chinensis (dodder) and goji berry, evidence is insufficient to rate their use for depression, atopic dermatitis, sunburn, cardiovascular disease, hypertension, obesity, or quality of life. We hold no effectiveness data for Dioscorea opposita, Achyranthes bidentata, or Cornus officinalis.

The evidence, ingredient by ingredient Rehmannia Dodder Goji American Dogwood

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rehmannia root is generally used in traditional medicine, but human safety data are limited and quality varies widely between products — use it cautiously. Cuscuta chinensis is generally well tolerated orally, though high doses may cause intestinal cramping and diarrhea; traditional sources suggest a maximum daily dose of 8 grams of dodder aerial parts.

Goji berry is generally safe as a food, but concentrated supplements have less safety data. A small number of case reports link goji to allergic reactions (facial swelling, throat tightness, mouth itching, skin rash) and, rarely, anaphylaxis.

One case of liver inflammation and one of acute hepatitis have been reported with goji or multi-ingredient products containing it, though it's unclear whether goji was responsible. For pregnancy: Rehmannia, Cuscuta, and goji all lack enough safety information and are best avoided during pregnancy.

For breastfeeding: there isn't enough reliable data on any of these ingredients to know whether they're safe — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Rehmannia Dodder Goji American Dogwood

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Goji, Rehmannia.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,001 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use warfarin (Coumadin) — goji can significantly increase your bleeding risk. Also screen for antihypertensive drugs, antidiabetes medications, flecainide, and any drugs your liver metabolizes (CYP2C9, CYP2C19, CYP2D6, or CYP3A4 substrates).

Use the search tool on this page with your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This traditional herbal teapill blend carries real medication interactions, especially if you take a blood thinner or heart medications. If you're on any prescription drugs — particularly warfarin, blood pressure medications, diabetes drugs, or medications your liver metabolizes — check them against our tool before starting.

Talk to your pharmacist about whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Left-Side Replenishing Teapills, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934860069
Net contents 1.2 Ounce(s); 34 Gram(s); 200 Pill(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 336479
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Left-Side Replenishing Teapills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Pill(s)
Maximum serving Sizes:
8 Pill(s)
Servings per container
25
UPC/BARCODE
739934860069
IngredientAmount% DV
Proprietary Extract Blend1360 mg--
Rehmannia glutinosa Root Extract0 NP--
Cuscuta chinensis Seed Extract0 NP--
Lycium barbarum Fruit Extract0 NP--
Dioscorea opposita Rhizome Extract0 NP--
Achyranthes bidentata Root Extract0 NP--
Cornus officinalis Fruit Extract0 NP--

Other ingredients: Magnesium Silicate, Hydrated, Maltose, Carbon, Activated, China Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Zuo Gui Wan

FDA Statement of Identity

Herbal Supplement

Precautions

Contains wheat (processed with wheat bran)

Not for use during pregnancy

Keep out of reach of children

Suggested/Recommended/Usage/Directions

Take 8 pills 3 times daily or as directed by your health care practitioner

Seals/Symbols

Plum Flower Guarantee FDA Registered cGMP Compliant Made at a cGMP Certified Facility Lab Tested Quality Verified Species Verified

General Statements

Foci Pharmaceutical 1929 Foci Pharmaceutical

Formulation

Sourced Sustainably US owned & operated since 1969. Made in China in partnership with the award winning Lanzhou Foci Pharmaceutical Co. Ltd.

See for yourself

Left-Side Replenishing Teapills by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Left-Side Replenishing Teapills by Plum Flower

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1360 mg per serving

Other (inactive) ingredients: Magnesium Silicate, Hydrated, Maltose, Carbon, Activated, China Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Left-Side Replenishing Teapills by Plum Flower Drug Interactions

Want to check YOUR meds against Left-Side Replenishing Teapills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,000Drugs
2 Major 998 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Left-Side Replenishing Teapills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lycium barbarum Fruit Extract8 drug types · 1,000 drugs

Warfarin (Coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).

Likelihood Probable Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Flecainide (Tambocor)

Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.

Likelihood Possible Evidence B

Rehmannia glutinosa Root Extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Left-Side Replenishing Teapills, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Web Address
www.plumflowerherbs.com
Pharmacist Counseling Corner

Left-Side Replenishing Teapills by Plum Flower: Common Questions

Does Left-Side Replenishing Teapills by Plum Flower interact with any medications?
Yes. Based on its ingredients, Left-Side Replenishing Teapills has a known interaction with 1,000 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Left-Side Replenishing Teapills contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is goji berry in this product safe if I'm on warfarin?
No — goji has a Major interaction with warfarin. Multiple case reports show it can block warfarin's breakdown, raising its level in your blood and increasing your bleeding risk. Do not take this product if you're on warfarin without talking to your doctor or pharmacist first.
Can I take this if I'm pregnant or breastfeeding?
The safety data aren't strong enough to recommend this product during pregnancy or breastfeeding. Rehmannia, dodder, and goji all lack sufficient information. Talk with your doctor or pharmacist before use if you're pregnant or nursing.
What are the side effects of dodder (Cuscuta chinensis) in this product?
At typical doses, dodder is generally well tolerated. At high doses, it may cause intestinal cramping, diarrhea, nausea, indigestion, or a heavy feeling in the stomach. One combination product report included loss of appetite with these symptoms, though it's unclear which ingredient caused them.
Has goji berry in this product been associated with any serious adverse effects?
Goji berries are safe for most people as a food, but concentrated supplements have less safety data. Rare allergic reactions — including facial swelling, throat tightness, and anaphylaxis — have been reported. A small number of case reports link goji or multi-ingredient products containing it to liver inflammation, though it's unclear whether goji was responsible.
What is rehmannia root used for in this product?
Rehmannia root is possibly effective for chronic kidney disease, based on the evidence we hold. Evidence is insufficient to know whether it works for aplastic anemia, atopic disease, osteoporosis, diabetes, or diabetic nephropathy.
Does this product have any ingredients we couldn't check for drug interactions?
Yes. We have no interaction data on file for Dioscorea opposita rhizome, Achyranthes bidentata root, or Cornus officinalis fruit, so we couldn't check whether they interact with your medications. Talk to your pharmacist if you have questions about them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Left-Side Replenishing Teapills label
Sources

Sources & How We Checked

Left-Side Replenishing Teapills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Dodder 3 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Mehrbani M, Choopani R, Fekri A, Mehrabani M, Mosaddegh M, Mehrabani M. The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial. J Ethnopharm PubMed
  3. Firoozabadi A, Zarshenas MM, Salehi A, Jahanbin S, Mohagheghzadeh A. Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression: a triple-blind randomized controlled trial study. J Evid Based Complementary Altern Med

See these in context on the Dodder monograph →

Goji 14 references
  1. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
  2. Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
  3. Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
  4. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
  5. Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
  6. Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
  7. Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
  8. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  9. Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
  10. Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11(4):383-90.
  11. Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010;76(1):7-19.
  12. Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
  13. Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
  14. Zhang J, Tian L, Xie B. Bleeding due to a probable interaction between warfarin and Gouqizi (Lycium Barbarum L.). Toxicol Rep. 2015;2:1209-1212. PubMed

See these in context on the Goji monograph →

American Dogwood 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the American Dogwood monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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