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Dietary supplement

Lemon Balm R5 Extract Ingredients & Drug Interactions

by Brain Forza

Lemon Balm R5 Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lemon Balm R5 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lemon Balm R5 Extract is a dietary supplement by Brain Forza with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm Aerial Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lemon Balm R5 Extract by Brain Forza

Ask about any prescription or over-the-counter medication and we check it for interactions with Lemon Balm R5 Extract by Brain Forza — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lemon Balm R5 Extract by Brain Forza

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Lemon Balm R5 Extract is a single-ingredient supplement containing lemon balm aerial extract (the above-ground plant parts). The capsules are made from vegetarian material and filled with maltodextrin and rice fiber as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports memory and cognition; stress and mood.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Anxiety, Stress, Depression — and 3 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Depression (Natural Medicines).
  • Also on file: Lemon Balm is rated "Possibly Effective" for Stress.
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Alzheimer disease, Anxiety, Cognitive function.

The evidence we hold shows lemon balm is possibly effective for cold sores (herpes labialis) and for stress and mood. That means some clinical trials show benefit, but the data isn't yet conclusive — more research is needed to be sure.

If you're considering it for one of these uses, talk with your pharmacist about what the current evidence means for you.

The evidence, ingredient by ingredient Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated in the short term for most healthy adults, though long-term safety and high-dose safety haven't been well studied. The most commonly reported side effects from oral use — dizziness and sedation — don't appear to happen more often with lemon balm than with placebo.

One case of heart rhythm changes (atrioventricular block and QT prolongation) was reported in a young woman using a multi-ingredient product containing lemon balm; symptoms resolved after stopping, but it's unclear whether lemon balm alone was responsible. If you're pregnant, the safety data isn't reliable enough — it's best to avoid it unless your doctor advises otherwise.

If you're breastfeeding, limited safety information exists, so talk to your doctor or pharmacist before use.

Side effects, ingredient by ingredient Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you use CNS depressants (sleep aids, anti-anxiety medications, seizure drugs, or anything that makes you drowsy) or thyroid hormone replacement therapy. Both interactions are Moderate severity and could reduce how well your medication works or add to side effects like drowsiness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lemon Balm R5 Extract may help with cold sores and stress, but it can interact with CNS depressants and thyroid medications. If you take a sleep aid, anti-anxiety drug, seizure medication, or thyroid hormone replacement, check your specific medications with the tool on this page before you start.

Talk to your pharmacist if you're pregnant, breastfeeding, or considering long-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lemon Balm R5 Extract, straight from the product label.

Brand Brain Forza
Barcode (UPC) 857056006155
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317972
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lemon Balm R5 Extract by Brain Forza, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
857056006155
IngredientAmount% DV
Lemon Balm Aerial Extract1000 mg--

Other ingredients: Vegetarian Capsules, Maltodextrin, Rice Fiber

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten Free GMO Free

Made in: California Imported Ingredients

Supports memory and cognition Helps support stress and mood Unique & potent extract

Stress, mood & cognitive support

Supports focus and memory Helps support overall mood Unique, high-potency extract

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Find us and tag us online @BrainForza #brainforza

Herb & Extracts

About Brain Forza Brain Forza has specialized in making the best organic mushroom and adaptogen powered products since 2010. Above all, we prioritize quality and science. We are driven by our goal to make the most functional super supplements on the market.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules once daily.

Take the capsules, or break them open into hot or cold water for herbal tea effect.

Precautions

Allergens: Manufactured in a facility that processes wheat, gluten, soy, milk, egg, shellfish, and tree nut ingredients.

Always contact a physician if you are taking medication, have a medical condition, or are pregnant or nursing.

May cause drowsiness.

Warning: This product is for adults only. Keep out of reach of children.

Asses tolerance first before operating a motor vehicle or heavy machinery- drowsiness may still occur in some.

Formula

High-potency Melissa officinalis extract 5% Rosmarinic acid

Rosmarinic acid Rosmarinic acid is a unique compound found in few plant species. It is known for supporting mood and having powerful antioxidant properties.

Brain Forza Lemon Balm R5 Use of Lemon balm (Melissa officinalis) can be dated to over 2,000 years ago by the Greeks. Brain Forza's Lemon balm R5 is a potent extract selected for its rare rosmarinic acid composition. Rosmarinic acid is very effective and noticeable even the first time it is used.

Halal & Kosher Compliant

Halal & Kosher Compliant

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in the USA

Herb ID Tracked

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lemon Balm R5 Extract by Brain Forza label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lemon Balm R5 Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lemon Balm R5 Extract by Brain Forza

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Lemon Balm Aerial Extract

Interacts with
264 drugs
1000 mg per serving Form: Rosmarinic Acid

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm Aerial Extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsules, Maltodextrin, Rice Fiber. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lemon Balm R5 Extract by Brain Forza Drug Interactions

Want to check YOUR meds against Lemon Balm R5 Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm Aerial Extract 264

Individual Drug Interactions

The ingredients in Lemon Balm R5 Extract interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lemon Balm R5 Extract interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm Aerial Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lemon Balm R5 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm Aerial Extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm Aerial Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lemon Balm R5 Extract, from the product label.

Brain Forza

See all Brain Forza products
Name
Brain Forza Labs Inc.
Street Address
200-871 Coronado Center Dr.
City
Henderson
State
NV
ZipCode
89052
Web Address
brainforza.com
Pharmacist Counseling Corner

Lemon Balm R5 Extract by Brain Forza: Common Questions

Does Lemon Balm R5 Extract by Brain Forza interact with any medications?
Yes. Based on its ingredients, Lemon Balm R5 Extract has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lemon Balm R5 Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Lemon Balm R5 Extract if I'm on a sleep medication or anti-anxiety drug?
Not without checking first. Lemon balm may add to the drowsiness or sedation from these medications, and the interaction is rated Moderate. Use the interaction checker on this page with your specific drug, or call us before you start.
Will this interfere with my thyroid medication?
It could. Lemon balm compounds can theoretically block how thyroid hormone is processed in your body. This interaction is Moderate, so run your thyroid drug through our checker before you start, or ask your pharmacist to review it.
Does lemon balm actually work for cold sores?
Our data shows it's possibly effective for cold sores — meaning some clinical trials found benefit, but the evidence isn't conclusive yet. If you want to try it, discuss whether it's right for your situation with your pharmacist or doctor.
Is it safe to take long-term?
Short-term safety in healthy adults looks fine, but long-term safety and high-dose safety haven't been well studied. If you're thinking about using it regularly, talk to your pharmacist about what we do and don't know.
Can I take this while pregnant or breastfeeding?
During pregnancy, safety data is too limited — it's best to avoid it unless your doctor advises otherwise. While breastfeeding, limited safety information exists, so talk to your doctor or pharmacist first.
What are the side effects?
Dizziness and sedation have been reported with oral lemon balm, but they don't seem to happen more often than with placebo. One case of serious heart rhythm changes was reported with a multi-ingredient product containing lemon balm, though it's unclear if lemon balm alone caused it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lemon Balm R5 Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lemon Balm R5 Extract label
Go deeper

The Full Monographs Behind Lemon Balm R5 Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Lemon Balm R5 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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