Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lemon Ingredients & Drug Interactions

by Zongle Therapeutics

Lemon label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lemon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Lemon is a dietary supplement by Zongle Therapeutics with 1 active ingredient. Its ingredients are commonly taken for vitamin c source, digestive support, flavoring and aromatherapy.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Lemon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lemon by Zongle Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Lemon by Zongle Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lemon by Zongle Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lemon. The liquid form also contains cold-pressed lemon oil as an inactive ingredient.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cleansing, digestive and respiratory support.
  • We looked for evidence on: Respiratory tract infections, Kidney stones (nephrolithiasis), Sore throat, Cold symptoms, General detoxification.
  • The closest evidence on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis).

The evidence we hold does not establish that lemon is effective for hay fever, anxiety, respiratory tract infections, high blood pressure, or kidney stones — all six uses listed in the data are rated as having insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon as a food or drink in normal amounts is well tolerated by most people. However, concentrated supplements or essential oils — and larger medicinal amounts — have not been well studied, so talk with your doctor before using this product that way.

In clinical trials, fresh lemon juice taken in larger amounts (60 mL twice daily) caused gastrointestinal side effects in a meaningful number of participants. About 37% reported some stomach upset compared to 8% on placebo; specifically, 21% had heartburn and 8% had upper stomach pain.

Data on safety during pregnancy and lactation is not on file for this product, so ask your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Lemon

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon.
  • The most serious interaction on file is rated Minor.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take itraconazole (Sporanox) for a fungal infection, check with your doctor or pharmacist before using this lemon product — it may increase itraconazole levels in your bloodstream.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This is a single-ingredient lemon liquid product with no established evidence of effectiveness for the conditions listed in the data. Its main concern is a minor interaction with itraconazole (an antifungal drug) — if you take that medication, avoid this product.

Larger amounts can cause heartburn and stomach upset in some people. Talk it over with your doctor or pharmacist before you start, especially if you're taking any medications or are pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lemon, straight from the product label.

Brand Zongle Therapeutics
Barcode (UPC) 856426006139
Net contents 4 Fluid Ounce(s); 118 mL
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 276604
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lemon by Zongle Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
2000
UPC/BARCODE
856426006139
IngredientAmount% DV
Lemon60 mg--

Other ingredients: Lemon Oil, Cold-Pressed

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Powerful purifying cleansing agent Provides cleansing and digestive benefits Supports healthy respiratory function Uplifting and energizing

100% pure therapeutic grade 100% pure & natural

Non GMO

Origin: USA, Mexico or Italy Bottled in USA

Suggested/Recommended/Usage/Directions

For aromatic, topical or internal use. For internal use dilute one drop in 4 fl. oz. of liquid.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If you are pregnant, nursing, or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas. Avoid sunlight or UV rays for up to 12 hours after applying product.

Formula

Citrus limon

FDA Statement of Identity

Essential Oil Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lemon by Zongle Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lemon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lemon by Zongle Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container2000 Amounts shown are per serving.

Lemon

Interacts with
1 drug
60 mg per serving

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...

Lemon monograph & interactions

Other (inactive) ingredients: Lemon Oil, Cold-Pressed. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lemon by Zongle Therapeutics Drug Interactions

Want to check YOUR meds against Lemon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Minor

Ingredients driving the most interactions

Lemon 1

Individual Drug Interactions

The ingredients in Lemon interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Lemon interact with drugs. Each result below shows which ingredient is responsible. Lemon

Each ingredient & the kinds of drugs it affects

For each ingredient in Lemon with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
Lemon full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lemon, from the product label.

Zongle Therapeutics

See all Zongle Therapeutics products
Name
Zongle Therapeutics LLC
City
Norcross
State
GA
ZipCode
30093
Web Address
www.zongletherapeutics.com
Pharmacist Counseling Corner

Lemon by Zongle Therapeutics: Common Questions

Does Lemon by Zongle Therapeutics interact with any medications?
Yes. Based on its ingredients, Lemon has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lemon contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lemon product give me heartburn?
It may. In a clinical trial, fresh lemon juice taken in larger amounts caused heartburn in about 21% of participants compared to 1% on placebo. If you have a sensitive stomach or acid reflux, be cautious or talk it through with your doctor first.
Can I take this if I'm pregnant or nursing?
The safety data is not on file for pregnancy or nursing, so there isn't enough information to know either way. Talk with your doctor or pharmacist for personalized advice based on your situation.
Is this product proven to help with hay fever or anxiety?
No — the evidence we hold does not establish that lemon is effective for hay fever, anxiety, respiratory infections, high blood pressure, or kidney stones. All six uses are rated as having insufficient reliable evidence.
What's the difference between this lemon liquid and just eating a lemon?
Concentrated supplements and larger medicinal amounts of lemon have not been well studied, unlike normal food amounts. If you're using this as a supplement rather than a food, check with your doctor or pharmacist first to make sure it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lemon is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lemon label
Go deeper

The Full Monographs Behind Lemon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon

Interacts with 1 drug

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...

Read the full Lemon monograph →
Sources

Sources & How We Checked

Lemon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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