Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Probiotic + Prebiotic Gummies Ingredients & Drug Interactions

by Member's Mark

Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Probiotic + Prebiotic Gummies is a dietary supplement by Member's Mark with 4 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans MTCC 5856, Bacillus subtilis DE111. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Probiotic + Prebiotic Gummies by Member's Mark

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 3 active ingredients: two probiotic bacterial strains — Bacillus coagulans MTCC 5856 and Bacillus subtilis DE111 — plus xylo-oligosaccharides, which act as a prebiotic (food for beneficial bacteria). The gummies also contain inactive fruit juice concentrates, pectin, and other excipients for taste and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.

Bacillus coagulans is possibly effective for constipation and IBS. Bacillus subtilis is possibly effective for antibiotic-associated diarrhea.

For other uses — athletic performance, cancer, liver disease, eczema, and diabetes — the evidence isn't established in the data we hold, or it's insufficient to rate. We have no effectiveness data on file for xylo-oligosaccharides.

The evidence, ingredient by ingredient Bacillus Coagulans Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both probiotic strains are generally well tolerated in healthy adults, though product quality and safety can vary. Limited safety data exist overall, so talk to your doctor before using if you have any health concerns.

A small number of trial participants on Bacillus subtilis reported headache or diarrhea. There's a theoretical concern that live probiotic bacteria could cause serious infection in people with central venous catheters, severely weakened immune systems, or critical illness — including preterm infants — but risk in otherwise healthy people with normal immune function is not established.

We hold no specific pregnancy or breastfeeding safety data for these strains; talk with your doctor for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Bacillus Coagulans Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bacillus Coagulans, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics are the main concern with a Moderate interaction — they can reduce how well these probiotic gummies work. Space your antibiotic doses and these gummies apart, and ask your pharmacist for the best timing.

Altogether, these interactions span 182 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

These gummies may help with constipation, IBS, or antibiotic-related diarrhea if the bacteria survive. The main thing to watch: space them away from antibiotics so the medication doesn't kill off the live organisms.

If you're severely ill, immunocompromised, or have a central line, ask your doctor first. Otherwise, check your exact medications with the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic + Prebiotic Gummies, straight from the product label.

Brand Member's Mark
Barcode (UPC) 078742256566
Net contents 150 Gummie(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 240067
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic + Prebiotic Gummies by Member's Mark, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummie(s)
Maximum serving Sizes:
2 Gummie(s)
Servings per container
75
UPC/BARCODE
078742256566
IngredientAmount% DV
Calories17 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Sugar4 Gram(s)--
Bacillus coagulans MTCC 58560 NP--
Xylo-oligosaccharides80 mg--
Bacillus subtilis DE1110 NP--
Proprietary Probiotic Blend0 NP--

Other ingredients: Apple juice concentrate, Apple puree concentrate, Strawberry puree, Raspberry puree, Blackberry puree, Mango puree concentrate, organic Peach puree, Black Currant juice concentrate, Blackberry juice concentrate, Pectin, Natural flavor, Lemon juice concentrate, Potassium Citrate, Ascorbic Acid, Purple Carrot juice concentrate, Microcrystalline Cellulose, Vegetable Oil, Beeswax, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

100% Money back guarantee Superior quality and performance We would like to hear from you with any comments or suggestions. In the continental U.S. or Canada, you can call us toll-free at 1.866.307.9794. You can also send us an email using the feedback icon at SamsClub.com.

Product of Germany.

Formula

Member's Mark Probiotic + Prebiotic Gummies are a delicious, convenient and healthy way to add probiotics to your daily routine. Each serving of our gummies provides 3 Billion CFUs of beneficial bacteria and 80 mg of xylooligosaccharides (XOS), better known as Prebiotics. Our bodies need a good balance of Probiotic bacteria to perform vital body functions, including healthy digestion and immune system health. Prebiotics feed the friendly bacteria in your gut.

Five real-fruit tasty flavors Strawberry Peach Blackberry Mango Raspberry

Gummies made from real fruit

Probiotic + Prebiotic 3 Billion CFUs per serving

Gummy matrix is made from real fruit.

Formulation

Discover the benefits of Member's Mark Probiotic + Prebiotic Gummies: No dairy, soy or gluten No preservatives No artificial colors or flavors Vegetarian (gelatin-free) No added sugar or high-fructose corn syrup

Vegetarian (gelatin-free)

Helps support digestive health Helps promote immune health

Digestive Immunity

This product does not contain any dairy, soy or gluten.

Our gummies are free of gelatin.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults and children 3 years and older, chew two (2) gummies per day. Chew thoroughly before swallowing.

Precautions

Contains: Tree nuts (coconut)

Tamper evident: Do not use if safety seal on bottle is broken or missing. This product is for use under adult supervision only.

Keep out of reach of children. Not intended for children under 3 years of age due to risk of choking.

Caution: We recommend you discuss the supplements and medications you take with your doctor.

Consult your doctor before taking this product if you have a medical condition, or are pregnant or nursing.

Excessive consumption may have a laxative effect.

Storage

Storage: Store in a dry, controlled room temperature area. For best results, we recommend you store this product in the original bottle.

See for yourself

Probiotic + Prebiotic Gummies by Member's Mark label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Probiotic + Prebiotic Gummies by Member's Mark

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummie(s) Dosage formGummy Or Jelly Servings per container75 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

4 Gram(s) per serving

Xylo-oligosaccharides

80 mg per serving

Proprietary Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Apple juice concentrate, Apple puree concentrate, Strawberry puree, Raspberry puree, Blackberry puree, Mango puree concentrate, Organic Peach puree, Black Currant juice concentrate, Blackberry juice concentrate, Pectin, Natural flavor, Lemon juice concentrate, Potassium Citrate, Ascorbic Acid, Purple Carrot juice concentrate, Microcrystalline Cellulose, Vegetable Oil, Beeswax, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic + Prebiotic Gummies by Member's Mark Drug Interactions

Want to check YOUR meds against Probiotic + Prebiotic Gummies?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic + Prebiotic Gummies with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans MTCC 58561 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D

Bacillus subtilis DE1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Probiotic + Prebiotic Gummies, from the product label.

Member's Mark

Name
Sam's West, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1.866.307.9794
Web Address
SamsClub.com
Pharmacist Counseling Corner

Probiotic + Prebiotic Gummies by Member's Mark: Common Questions

Does Probiotic + Prebiotic Gummies by Member's Mark interact with any medications?
Yes. Based on its ingredients, Probiotic + Prebiotic Gummies has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic + Prebiotic Gummies contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between a probiotic and a prebiotic?
A probiotic is live beneficial bacteria (the two Bacillus strains here). A prebiotic is food for those bacteria (the xylo-oligosaccharides). Together they work to support your gut health.
Can I take these gummies while I'm on an antibiotic?
Not at the same time. Antibiotics kill bacteria, including the live organisms in these gummies, so they won't work as well. Ask your pharmacist how far apart to space them — usually a few hours is enough.
Do these actually work for constipation or IBS?
Bacillus coagulans shows possibly effective evidence for both constipation and IBS. Bacillus subtilis is possibly effective for antibiotic-related diarrhea. Results can vary person to person.
Are there any side effects I should know about?
In trials, headache and diarrhea were reported rarely with Bacillus subtilis. Both strains are generally well tolerated in healthy people, though product quality varies. If you're severely ill or have a weakened immune system, talk to your doctor first.
Is it safe to take these while pregnant or breastfeeding?
We don't have enough safety data to know either way. Talk with your doctor or pharmacist before taking these if you're pregnant or nursing — they can give you personalized advice.
What are the gummies made with besides the probiotics?
Fruit juice and puree concentrates, pectin for texture, and some added vitamins like vitamin C. No artificial sweeteners or colors are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic + Prebiotic Gummies is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic + Prebiotic Gummies label
Sources

Sources & How We Checked

Probiotic + Prebiotic Gummies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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