Lime Fruit 450 mg 4:1 Extract Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Lime Fruit 450 mg 4:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lime Fruit 450 mg 4:1 Extract is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for source of vitamin c, digestive upset, skin care.Based on those ingredients, 886 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lime Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Lime Fruit Extract at 450 mg per capsule in a 4:1 concentrate form. Lime fruit is rich in vitamin C and plant compounds called phenolics that give it its characteristic tartness and potential health effects.
The capsules also contain gelatin and water as inactive ingredients to hold and deliver the extract.
Does it work?
Couldn't assess
The evidence for lime extract isn't established in the data we hold. The product has been studied for iron deficiency anemia, malaria, sickle cell disease, and smoking cessation, but the available evidence for all of these uses is rated as insufficient to draw firm conclusions.
If you're considering this for a specific health goal, talk it over with your doctor to see if there are better-studied options available.
How safe is it?
Well-documented data
Lime as a food is generally well tolerated by most people. However, concentrated extracts like this one haven't been as thoroughly studied as whole fruit, so caution is advised — the safety data on concentrated products is limited.
Orally, a small number of people have reported diarrhea, and lime can rarely cause tooth sensitivity or wear. Topically (which isn't how you'd use a capsule), lime can trigger allergic skin reactions or a sunburn-like condition called phytophotodermatitis when skin is exposed to the sun afterward.
The facts don't include enough data on use during pregnancy or breastfeeding, so talk with your doctor or pharmacist if you're pregnant, nursing, or planning to be.
Meds to double-check
Moderate interaction found
Check your medications against these two drug types before starting: first, drugs that are photosensitizing (certain antibiotics, NSAIDs, and others), because lime extract may increase your risk of severe sunburn; and second, drugs metabolized by the liver enzyme CYP3A4, such as sildenafil, because the extract may slow how quickly your body clears them. Your pharmacist can confirm whether any of your prescriptions fall into either category.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
TerraVita Premium Collection's Lime Fruit Extract is a single-ingredient supplement whose effectiveness for the conditions studied isn't yet proven by reliable evidence. The main concern is that it may interact with medications your liver clears through a specific enzyme, and it may raise your skin's sensitivity to sun damage if you take photosensitizing drugs.
Before you start this supplement, check with your doctor or pharmacist about your current medications, especially if you take any that your liver processes.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lime Fruit 450 mg 4:1 Extract, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435207076 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2023 |
| DSLD ID | 289261 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2017 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Take 1 capsule, 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Lime Fruit Extract
Interacts with886 drugs
Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people...
Lime Fruit Extract monograph & interactionsOther (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
TerraVita Premium Collection's Lime Fruit Extract can interact with medications in two main ways.
Through its content of plant compounds called phenolics, it may slow how your body clears certain drugs that rely on a liver enzyme called CYP3A4 (cytochrome P450 3A4 substrates), which is a Moderate concern — this has been shown in animal studies with high doses. Additionally, lime extract may increase your skin's sensitivity to sun damage if you're taking photosensitizing drugs (a Moderate interaction).
Read the full breakdown — every affected drug type, severity by severity
The CYP3A4 interaction matters most if you take medications like sildenafil or others metabolized by that enzyme pathway — the extract could cause those drugs to stay in your system longer and potentially stronger than expected. Photosensitizing drugs include certain antibiotics, nonsteroidal anti-inflammatory pain relievers, and some other classes; combined with lime extract, your risk of severe sunburn or phototoxic reactions rises.
Additionally, we could not check a few inactive ingredients for interactions. Run your exact medications through the search tool on this page to see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lime Fruit 450 mg 4:1 Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lime Fruit 450 mg 4:1 Extract interact with 886 drugs. Click any drug to see the details.
1 of the 1 ingredient in Lime Fruit 450 mg 4:1 Extract interact with drugs. Each result below shows which ingredient is responsible. Lime Fruit Extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acalabrutinib interactionAcepromazineAtravet
How Acepromazine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acepromazine interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Lime Fruit 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Lime Fruit ExtractPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime Fruit Extract + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lime Fruit 450 mg 4:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Lime Fruit Extract
Cytochrome P450 3A4 (Cyp3A4) Substrates
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4. This has been demonstrated in rats treated with sildenafil, a CYP3A4 substrate, and high doses of lime juice.
Photosensitizing Drugs
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Brand information
Manufacturer and brand details for Lime Fruit 450 mg 4:1 Extract, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection: Common Questions
Does Lime Fruit 450 mg 4:1 Extract by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with anemia or malaria?
What are the side effects?
Is this safe during pregnancy or breastfeeding?
What does the 4:1 extract mean?
What's in the capsule besides the lime extract?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lime Fruit 450 mg 4:1 Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lime Fruit 450 mg 4:1 Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Lime Fruit 450 mg 4:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lime 20 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Roesyanto-Mahadi ID, Geursen-Reitsma AM, van Joost T, et al. Sensitization to fragrance materials in Indonesian cosmetics. Contact Dermatitis 1990;22:212-7. PubMed
- Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
- Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37. PubMed
- Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
- Wagner, A. M., Wu, J. J., Hansen, R. C., Nigg, H. N., and Beiere, R. C. Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am.J Contact Dermat. 2002;13(1):10-14. PubMed
- Garcia, O. P., Diaz, M., Rosado, J. L., and Allen, L. H. Ascorbic acid from lime juice does not improve the iron status of iron-deficient women in rural Mexico. Am.J.Clin.Nutr. 2003;78(2):267-273. PubMed
- Coffman, K., Boyce, W. T., and Hansen, R. C. Phytophotodermatitis simulating child abuse. Am.J Dis.Child 1985;139(3):239-240. PubMed
- Adegoke SA, Oyelami OA, Olatunya OS, Adeyemi LA. Effects of lime juice on malaria parasite clearance. Phytother Res. 2011;25(10):1547-50. PubMed
- Adegoke SA, Shehu UA, Mohammed LO, Sanusi Y, Oyelami OA. Influence of lime juice on the severity of sickle cell anemia. J Altern Complement Med. 2013;19(6):588-92. PubMed
- Assarian Z, Nixon RL. Protein contact dermatitis caused by lime in a pastry chef. Contact Dermatitis. 2015;73(1):54-6. PubMed
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- Flugman SL. Mexican beer dermatitis: a unique variant of lime phytophotodermatitis attributable to contemporary beer-drinking practices. Arch Dermatol. 2010;146(10):1194-5. PubMed
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