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Dietary supplement

Lion's Mane 500 mg Ingredients & Drug Interactions

by NOW

Lion's Mane 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane 500 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lions Mane Mushroom, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane 500 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane 500 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane 500 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lion's mane mushroom powder at 500 mg per capsule. The capsule also holds inactive ingredients—vegetable polysaccharide (the capsule material itself) and inulin powder (a prebiotic fiber used as a filler).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: general well-being and maintenance.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for lion's mane mushroom isn't established in our data. We hold ratings for six uses—Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment—and all of them show insufficient reliable evidence to rate.

That means the science doesn't yet support a clear claim that it works for any of these, though research is ongoing.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane mushroom is generally well tolerated when eaten as food, but long-term supplement safety hasn't been studied well. The most common side effects reported in trials are gastrointestinal discomfort, nausea, and skin rash—though these are uncommon.

If you're pregnant or breastfeeding, there isn't enough safety data to know either way, so it's best to talk with your doctor or pharmacist before taking it. The same goes if you're considering it for someone else in those situations.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants) or antiplatelet drugs, diabetes medications, or immunosuppressants. Lion's mane may increase bleeding risk, lower blood sugar additively, or interfere with immune suppression.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane mushroom is generally well tolerated and shows up in many wellness routines, but evidence for specific health claims isn't established yet. If you take blood thinners, diabetes medications, or immune-suppressing drugs, check with your doctor or pharmacist before starting—the interactions are theoretical but documented.

For anyone else, a conversation with your own healthcare provider about whether it fits your routine is a good next step.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane 500 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739047892
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 292050
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane 500 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
733739047892
IngredientAmount% DV
Lions Mane Mushroom, Powder1000 mg--

Other ingredients: Vegetable Polysaccharide, Inulin, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: take 2 capsules daily.

Formula

Lion’s mane is an edible mushroom that has a long history of use by traditional herbalists in Asia for the maintenance of general well-being. More recent scientific research suggests that certain constituents in Lion’s mane may support your neuronal health. NOW Lion’s mane uses the mushroom’s fruiting bodies, which have naturally occurring beta-glucans.

Super mushroom Made with Organic Lion's Mane mushrooms

Triangle K (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: for adults only.

Consult a physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Non GMO Project Verified nongmoproject.org

Vegetarian/Vegan

Certified Organic by QAI.

Packaged and quality tested in the USA.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.

General Statements

Capsule size

Botanicals/Herbs Family owned since 1968.

Seals/Symbols

Non GMO Project Verified nongmoproject.org

Triangle K (Kosher)

Quality GMP Assured

FDA Statement of Identity

A Dietary Supplement

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane 500 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane 500 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lions Mane Mushroom, Powder

Interacts with
327 drugs
1000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lions Mane Mushroom, Powder monograph & interactions

Other (inactive) ingredients: Vegetable Polysaccharide, Inulin, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane 500 mg by NOW Drug Interactions

Want to check YOUR meds against Lion's Mane 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lions Mane Mushroom, Powder 327

Individual Drug Interactions

The ingredients in Lion's Mane 500 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane 500 mg interact with drugs. Each result below shows which ingredient is responsible. Lions Mane Mushroom, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lions Mane Mushroom, Powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lions Mane Mushroom, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane 500 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Lion's Mane 500 mg by NOW: Common Questions

Does Lion's Mane 500 mg by NOW interact with any medications?
Yes. Based on its ingredients, Lion's Mane 500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
Not without checking first. Lion's mane may increase your bleeding risk when combined with blood thinners. Talk to your doctor or pharmacist about your specific medication before you start.
Will this affect my diabetes medication?
Possibly. Lion's mane appears to lower blood sugar, so taking it alongside diabetes drugs could cause your blood sugar to drop further than intended. Check with your doctor or pharmacist before adding it.
What are the most common side effects?
Gastrointestinal discomfort, nausea, and skin rash are the most common—though they're uncommon overall. Most people tolerate it well.
Is there evidence this actually works for memory or focus?
The evidence isn't established yet. We don't have reliable data to say it works for Alzheimer disease, cognitive function, anxiety, or the other uses it's marketed for, though research is ongoing.
Is it safe during pregnancy or breastfeeding?
There isn't enough safety data to know either way. It's best to avoid it and talk with your doctor or pharmacist about your options if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane 500 mg label
Go deeper

The Full Monographs Behind Lion's Mane 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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