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Dietary supplement

Lion's Mane Mushroom 2,100 mg Ingredients & Drug Interactions

by Nutricost

Lion's Mane Mushroom 2,100 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Mushroom 2,100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Mushroom 2,100 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane Mushroom 2,100 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Mushroom 2,100 mg by Nutricost — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane Mushroom 2,100 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lion's mane mushroom at 2,100 mg per capsule. The inactive ingredients are pullulan capsule, magnesium stearate, and olive oil.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for lion's mane mushroom isn't established in the data we hold. The product's potential uses include Alzheimer disease, anxiety, athletic performance, cancer, and cognitive function — but the research so far is insufficient to rate how well it works for any of these.

If you're considering it for a specific reason, it's worth talking that over with your doctor.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when eaten as food, though long-term supplement safety hasn't been studied in depth. The most common side effects in trials were gastrointestinal discomfort, nausea, and skin rash.

There isn't enough safety data to know whether it's safe in pregnancy or while breastfeeding — the facts advise against use in both cases, so talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), diabetes medications (Moderate risk of added blood-sugar lowering), or immunosuppressants (Moderate risk of interference with your therapy). Use the tool on this page to search your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane may be worth considering if you're curious about cognitive support, but the evidence for its effectiveness isn't solid yet. The main caution is if you take blood thinners, diabetes medications, or immunosuppressants — check with your own doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Mushroom 2,100 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 810014670287
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 306330
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Mushroom 2,100 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
810014670287
IngredientAmount% DV
Lion's Mane Mushroom2100 mg--

Other ingredients: Pullulan Capsule, Magnesium Stearate, Olive Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 3 capsules daily with 8-12 oz of water or as directed by your healthcare professional.

Formulation

Third Party Tested

Non-GMO Gluten-free

Made and quality tested in the USA with globally sourced ingredients.

Certified CCOF Organic

Vegetarian product

Non-GMO product

Precautions

Notice: For healthy individuals 18 years and older. Keep out of reach of children.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Do not use if safety seal broken or missing.

Storage

Notice: Store in a cool, dry place.

Seals/Symbols

Certified CCOF Organic

Quality Nutricost Guaranteed GMP GMP Compliant Facility

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Mushroom 2,100 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Mushroom 2,100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Mushroom 2,100 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Mushroom

Interacts with
327 drugs
2100 mg per serving Form: Hericium erinaceus

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom monograph & interactions

Other (inactive) ingredients: Pullulan Capsule, Magnesium Stearate, Olive Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Mushroom 2,100 mg by Nutricost Drug Interactions

Want to check YOUR meds against Lion's Mane Mushroom 2,100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom 327

Individual Drug Interactions

The ingredients in Lion's Mane Mushroom 2,100 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Mushroom 2,100 mg interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Mushroom 2,100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Mushroom 2,100 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Lion's Mane Mushroom 2,100 mg by Nutricost: Common Questions

Does Lion's Mane Mushroom 2,100 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Lion's Mane Mushroom 2,100 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Mushroom 2,100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data yet, so it's best to avoid it during pregnancy and breastfeeding. Talk with your doctor or pharmacist if you're in either situation and interested in trying it.
What side effects might I notice?
The most common ones in trials were gastrointestinal discomfort, nausea, and skin rash. Most people tolerate it well, but if you notice any of these, stop and let your pharmacist know.
Does this actually work for memory or brain fog?
The evidence for lion's mane on cognitive function, cognitive impairment, and anxiety isn't solid enough to rate yet. It's a popular choice, but we don't have reliable data on how well it works for these uses.
What is lion's mane mushroom, and what does it do in the body?
Lion's mane is an edible mushroom. Research suggests it may have effects on blood clotting, blood sugar, and immune function, but those effects aren't yet proven enough in humans to say what it does in your body.
Are there any fillers or extra stuff in the capsule?
Beyond the lion's mane itself, the capsule contains pullulan (the capsule material), magnesium stearate, and olive oil — all inactive ingredients that help make the capsule work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane Mushroom 2,100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Mushroom 2,100 mg label
Go deeper

The Full Monographs Behind Lion's Mane Mushroom 2,100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane Mushroom 2,100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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