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Dietary supplement

Lion's Mane Mushroom (30% Polysaccharides) Ingredients & Drug Interactions

by BulkSupplements.com

Lion's Mane Mushroom (30% Polysaccharides) label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Mushroom (30% Polysaccharides) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Mushroom (30% Polysaccharides) is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lion's mane mushroom extract, standardized to 30% polysaccharides. Polysaccharides are complex carbohydrates in the mushroom that are thought to be the main active compounds.

The powder form makes it easy to mix into drinks or food.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for lion's mane mushroom is insufficient to establish whether it works for Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment. That doesn't mean it doesn't work — it means the research to date hasn't met the bar to make a reliable claim.

If you're considering lion's mane for one of these uses, talk with your doctor about what evidence exists outside our database and whether it makes sense for you.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane mushroom is generally well tolerated as a food, though long-term supplement safety hasn't been studied extensively. The most common side effects from oral use are gastrointestinal discomfort, nausea, and skin rash.

There isn't enough safety data to recommend it during pregnancy or while breastfeeding — talk with your doctor or pharmacist before taking it if either applies to you.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners like warfarin or aspirin (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), or immunosuppressants after a transplant or for autoimmune disease (Moderate risk of reduced drug effectiveness).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane mushroom is a single-ingredient supplement that's generally easy on the stomach for most people. The main caution is if you take blood thinners, diabetes medications, or immunosuppressants — check with your pharmacist or doctor first.

Evidence for its claimed uses isn't well established yet, so be realistic about what to expect. Run your medications through the checker before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Mushroom (30% Polysaccharides), straight from the product label.

Brand BulkSupplements.com
Net contents 1 kg; 35.3 oz
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 252775
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
2000
IngredientAmount% DV
Lion's Mane Mushroom Extract500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Color may vary

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 500 mg once or twice daily, or as directed by a physician.

Storage

Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Mushroom (30% Polysaccharides) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.

Lion's Mane Mushroom Extract

Interacts with
327 drugs
500 mg per serving Form: Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Lion's Mane Mushroom (30% Polysaccharides)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane Mushroom (30% Polysaccharides) interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Mushroom (30% Polysaccharides) interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Mushroom (30% Polysaccharides) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Mushroom (30% Polysaccharides), from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com: Common Questions

Does Lion's Mane Mushroom (30% Polysaccharides) by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Lion's Mane Mushroom (30% Polysaccharides) has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Mushroom (30% Polysaccharides) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are polysaccharides and why does this product highlight 30% of them?
Polysaccharides are complex carbohydrates found in lion's mane mushroom. The 30% standardization means this extract is concentrated to contain that amount of polysaccharides — the compounds thought to drive the mushroom's effects. A higher percentage generally means more of what researchers believe is the active part of the mushroom.
Can I take lion's mane if I'm on blood thinners?
Not without checking first. Lab research suggests lion's mane may slow blood clotting, and combining it with blood thinners like warfarin or aspirin could raise your bleeding risk. Talk with your doctor or pharmacist before starting — they know your exact medication and can tell you whether it's safe for you.
What are the most common side effects?
Gastrointestinal discomfort, nausea, and skin rash are the ones reported most often. Most people tolerate it fine, but if your stomach is sensitive, start with a small amount and see how you feel.
Is there solid evidence lion's mane works for brain health or memory?
Not in the data we hold. For Alzheimer's disease, cognitive function, cognitive impairment, anxiety, and other uses people ask about, the evidence is insufficient to say it works reliably. You might find research elsewhere, but be clear-eyed about what's proven so far.
Can I take lion's mane while pregnant or breastfeeding?
The safety data isn't there yet, so it's best to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist if you're thinking about it — they can help you decide what's right for your situation.
Does this powder have any fillers or binders?
No — the inactive ingredients list is empty, so you're getting lion's mane extract and nothing else in the powder.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane Mushroom (30% Polysaccharides) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Mushroom (30% Polysaccharides) label
Go deeper

The Full Monographs Behind Lion's Mane Mushroom (30% Polysaccharides)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane Mushroom (30% Polysaccharides)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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