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Dietary supplement

Lion's Mane Mushroom Ingredients & Drug Interactions

by Fresh Nutrition

Lion's Mane Mushroom label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Mushroom against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Mushroom is a dietary supplement by Fresh Nutrition with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Lion's Mane Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lion's Mane Mushroom by Fresh Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Mushroom by Fresh Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lion's Mane Mushroom by Fresh Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic Lion's Mane Mushroom. The capsule itself is vegetarian.

Lion's mane is a mushroom used in traditional practice and studied for potential effects on cognition and immune function, though the evidence in our data is not yet established for those uses.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Alzheimer disease, Dementia, Parkinson disease — and 2 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

We hold insufficient reliable evidence to rate lion's mane for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment. That means the studies we have aren't robust enough yet to say whether it works for these purposes.

If you're considering it for a specific condition, talk it over with your doctor or pharmacist to see what the current research supports.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when taken by mouth. The most commonly reported side effects in studies were gastrointestinal discomfort, nausea, and skin rash — though these occurred in a small number of participants.

The long-term safety of lion's mane supplements hasn't been well studied, so caution is warranted with prolonged use. Because there isn't enough safety data, the facts advise against use during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized guidance if you're in either situation.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you're on blood thinners (anticoagulants or antiplatelet drugs like warfarin, clopidogrel, or aspirin), diabetes medications, or immunosuppressants — all three carry Moderate-severity interactions with lion's mane mushroom.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane may appeal to you if you're interested in cognition or immune support, but the evidence we hold is not yet established for any of those uses. If you take blood thinners, diabetes drugs, or immunosuppressants, you'll want to check with your doctor or pharmacist before starting — the interactions are Moderate severity and matter.

Pregnancy and breastfeeding are best avoided until you've discussed it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Mushroom, straight from the product label.

Brand Fresh Nutrition
Barcode (UPC) 851039008051
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 242012
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Mushroom by Fresh Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
851039008051
IngredientAmount% DV
organic Lion's Mane Mushroom1500 mg--

Other ingredients: Vegetarian Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan

Non GMO Gluten free Soy free

No artificial colors. No artificial flavors. No preservatives. Made with Non-GMO, all natural ingredients!

Quality Verified Third Party Tested For Quality And Purity To provide our consumers with complete confidence in our product quality, every batch is 3rd party tested for quality & purity.

Cognitive support & brain function Nerve regeneration & remyelination Increased nerve growth factor Improved digestive function Immune support & antioxidant

Carefully sourced from top quality Mushroom Farm, with no fillers or additives. Carefully sourced from the local FDA registered facility with only American Ingredients. Fresh Nutrition produces the most potent Lions Mane Mushroom Products.

General Statements

Fresh Nutrition Our goal is to create high-quality natural products using both organic and responsibly sourced ingredients to optimize health and well-being.

All natural

Appreciate to choose the best Lion's Mane with affordable price through Fresh Nutrition.

Formula

Lions Mane Mushrooms Also known as Hericium Erinaceus, Yamabushitake or Satyr's Beard) is used for centuries as a general tonic and health treatment, is native to China, Japan, North America. It is a modern medicinal mushroom and powerful superfood adaptogen for the brain, nerves and immune system.

Made with Non-GMO, all natural ingredients!

Suggested/Recommended/Usage/Directions

Recommended Dosage: 3 capsules daily

Seals/Symbols

CCOF California Certified Organic Farmers Non GMP Project Verified nongmoproject.org DNA Verified Ingredients

Made in USA

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Mushroom by Fresh Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Mushroom label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Mushroom by Fresh Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Organic Lion's Mane Mushroom

Interacts with
327 drugs
1500 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane Mushroom monograph & interactions

Other (inactive) ingredients: Vegetarian Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane Mushroom by Fresh Nutrition Drug Interactions

Want to check YOUR meds against Lion's Mane Mushroom?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

organic Lion's Mane Mushroom 327

Individual Drug Interactions

The ingredients in Lion's Mane Mushroom interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Mushroom interact with drugs. Each result below shows which ingredient is responsible. organic Lion's Mane Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Mushroom with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Lion's Mane Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Mushroom, from the product label.

Fresh Nutrition

See all Fresh Nutrition products
Name
Fresh Nutrition Inc.
Street Address
River Rd
City
Keizer
State
OR
ZipCode
97303
Web Address
www.fresh-nutrition.com
Pharmacist Counseling Corner

Lion's Mane Mushroom by Fresh Nutrition: Common Questions

Does Lion's Mane Mushroom by Fresh Nutrition interact with any medications?
Yes. Based on its ingredients, Lion's Mane Mushroom has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Mushroom contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is lion's mane mushroom?
It's a mushroom used in traditional practice and in our data studied for potential effects on cognition and immune function. This product contains the organic mushroom itself as its single active ingredient.
Can I take lion's mane if I'm pregnant or breastfeeding?
The facts advise against it in both situations because there isn't enough safety data to know either way. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What side effects might I have?
Lion's mane is generally well tolerated, but a small number of people reported gastrointestinal discomfort, nausea, or a skin rash. Long-term safety hasn't been well studied, so if you take it daily for months, keep an eye out for any new symptoms.
Does lion's mane actually improve memory or cognitive function?
The evidence we hold is insufficient to rate it for cognitive function, Alzheimer disease, or cognitive impairment — the studies so far aren't robust enough to say it works. If that's why you're considering it, talk with your doctor about what the current research shows.
Are there any other ingredients in this capsule besides the mushroom?
The only other ingredient is the vegetarian capsule material itself — no fillers or binders were added.
Can I take this with my blood thinner?
Not without talking to your doctor or pharmacist first. Lion's mane may increase bleeding risk when combined with blood thinners — that's a Moderate-severity interaction, so you need their input on whether it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane Mushroom is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Mushroom label
Go deeper

The Full Monographs Behind Lion's Mane Mushroom’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane Mushroom's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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