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Dietary supplement

LucidiSPORE Ingredients & Drug Interactions

by Natrium Health

LucidiSPORE label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LucidiSPORE against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LucidiSPORE is a dietary supplement by Natrium Health with 1 active ingredient. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Spore Oil Supercritical CO2 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against LucidiSPORE by Natrium Health

Ask about any prescription or over-the-counter medication and we check it for interactions with LucidiSPORE by Natrium Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of LucidiSPORE by Natrium Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

LucidiSPORE is a single-ingredient softgel: reishi spore oil made using supercritical CO2 extraction, a method that concentrates the active compounds from reishi mushroom spores. The capsule itself is made from gelatin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune function, stress and sleep support.
  • We looked for evidence on: Stress, Insomnia, Chronic fatigue syndrome (CFS), Psychological well-being, fatigue, restlessness — and 1 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer-related fatigue, Insomnia, Stress, Psychological well-being.

The data we hold shows reishi mushroom is possibly ineffective for high cholesterol (hyperlipidemia). For altitude sickness, Alzheimer disease, and athletic performance, there isn't enough reliable evidence to rate whether it works.

If you're considering LucidiSPORE for one of these uses, the evidence doesn't yet support it.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom is generally well tolerated in the short term, but long-term safety hasn't been well studied. Common side effects include dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Some people have reported respiratory allergy to reishi spores, as well as sore throat and runny nose. Rarely, dizziness, insomnia, and headache have been noted.

There isn't enough safety data to recommend LucidiSPORE during pregnancy or breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking LucidiSPORE, check with your doctor or pharmacist if you take blood thinners (anticoagulant or antiplatelet drugs) — reishi may increase bleeding risk at higher doses. Also double-check if you're on blood pressure medications, since reishi can lower blood pressure and might cause yours to drop too much.

If you take diabetes medications, confirm it's safe, because reishi may add to their blood-sugar-lowering effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

LucidiSPORE may be worth considering if you're interested in reishi for general wellness, though evidence for most uses is limited or absent. If you take blood thinners, blood pressure medications, or diabetes drugs, you'll need to check with your doctor or pharmacist first — the interactions are documented and could affect how your medications work.

Start by confirming it's safe for you and your prescriptions with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LucidiSPORE, straight from the product label.

Brand Natrium Health
Barcode (UPC) 858163008179
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233387
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LucidiSPORE by Natrium Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
858163008179
IngredientAmount% DV
Reishi Spore Oil Supercritical CO2 extract500 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Natrium Health Science Powered by Nature

Formulation

Benefits and uses Healthy immune function Stress management support Inflammation support Restful sleep support

Made in the USA with US and imported ingredients

Immune system and stress defender

Gluten free Non GMO

All natural ingredients

Formula

Highest triterpene content

Supercritical Reishi Spore Oil

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 softgel up to 2 times daily.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight or heat.

Precautions

Disclaimer: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LucidiSPORE by Natrium Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LucidiSPORE label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LucidiSPORE by Natrium Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Reishi Spore Oil Supercritical CO2 extract

Interacts with
375 drugs
500 mg per serving Form: Triterpenes

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Spore Oil Supercritical CO2 extract monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

LucidiSPORE by Natrium Health Drug Interactions

Want to check YOUR meds against LucidiSPORE?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Reishi Spore Oil Supercritical CO2 extract 375

Individual Drug Interactions

The ingredients in LucidiSPORE interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in LucidiSPORE interact with drugs. Each result below shows which ingredient is responsible. Reishi Spore Oil Supercritical CO2 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in LucidiSPORE with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Spore Oil Supercritical CO2 extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Spore Oil Supercritical CO2 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LucidiSPORE, from the product label.

Natrium Health

See all Natrium Health products
Name
Natrium Health
Street Address
8205 S. Priest Dr. #11750
City
Tempe
State
AZ
ZipCode
85284
Web Address
www.NatriumHealth.com
Pharmacist Counseling Corner

LucidiSPORE by Natrium Health: Common Questions

Does LucidiSPORE by Natrium Health interact with any medications?
Yes. Based on its ingredients, LucidiSPORE has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LucidiSPORE contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the side effects I might experience?
Most common side effects are dizziness, dry mouth, itching, nausea, rash, and stomach upset. Respiratory allergy to reishi spores can happen, with sore throat and runny nose reported. Rarely, insomnia and headache have been noted. Stop and talk with your pharmacist if any bother you.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to recommend LucidiSPORE during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.
Does reishi actually work for what people use it for?
The data we hold shows reishi is possibly ineffective for high cholesterol. For altitude sickness, Alzheimer disease, and athletic performance, there isn't enough reliable evidence to say whether it works. If you're considering it for one of these uses, the evidence doesn't yet support it.
Why does reishi have so many drug interactions?
Reishi can lower blood pressure and blood sugar, and may affect bleeding. Those properties mean it can theoretically interact with medications that do similar things. The good news: most interactions are at higher doses, and you can check your exact medications on this page before taking LucidiSPORE.
How long can I safely take this?
Reishi is generally well tolerated in the short term, but long-term safety hasn't been well studied. If you plan to use LucidiSPORE regularly for weeks or months, mention that to your doctor or pharmacist so they can advise you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LucidiSPORE label
Go deeper

The Full Monographs Behind LucidiSPORE’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

LucidiSPORE's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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