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Dietary supplement

Lutein 15 mg Ingredients & Drug Interactions

by Nature's Blend

Lutein 15 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein 15 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein 15 mg is a dietary supplement by Nature's Blend with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin Esters. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein 15 mg by Nature's Blend

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein 15 mg by Nature's Blend — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein 15 mg by Nature's Blend

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains 2 active ingredients: lutein esters and zeaxanthin esters. Both are carotenoids, plant pigments that concentrate in the eye's macula (the part responsible for sharp central vision).

The product also contains several inactive ingredients — rice bran oil, gelatin, glycerin, sunflower oil, beeswax, soy lecithin, caramel, and purified water — which help deliver and stabilize the active compounds.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye and skin health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein esters are possibly effective for age-related macular degeneration (AMD) and cataracts, but the evidence for other conditions — retinitis pigmentosa, necrotizing enterocolitis, retinopathy of prematurity, and bronchopulmonary dysplasia — rates as possibly ineffective. Zeaxanthin esters are possibly effective for AMD as well.

For zeaxanthin's other studied uses — age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia — the evidence we hold is insufficient to rate it either way.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both lutein esters and zeaxanthin esters are generally well tolerated at typical supplement doses. Lutein at doses up to 20 mg daily hasn't caused reported adverse effects.

Both ingredients are rated likely safe in pregnancy and lactation, but the safety data on concentrated supplement doses (not food sources) during these periods is limited. If you're pregnant or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drug — including insulin, metformin, or other glucose-lowering medications — check it against this product before you start. Zeaxanthin may increase the risk of low blood sugar (a Moderate severity concern), and your doctor may want to monitor your blood sugar levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help protect eye health in age-related macular degeneration and cataracts, though the evidence is "possibly effective" rather than proven. The main caution is for anyone taking antidiabetes medication — the zeaxanthin may theoretically lower blood sugar further.

Check your exact medications with the tool on this page, and discuss the product with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein 15 mg, straight from the product label.

Brand Nature's Blend
Barcode (UPC) 079854080360
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274669
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein 15 mg by Nature's Blend, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
079854080360
IngredientAmount% DV
Lutein Esters15 mg--
Zeaxanthin Esters600 mcg--

Other ingredients: Rice Bran Oil, Gelatin, Glycerin, Sunflower Oil, Bees Wax, Soy Lecithin, Caramel, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Precautions

Keep out of the reach of children.

Double safety sealed for your protection. Do not use if either seal is broken or missing.

Formulation

Preservative & gluten free. No starch, salt, artificial colors, artificial flavors, wheat, yeast, or corn added.

This product is manufactured under strict quality control guidelines; therefore, purity and label potency are guaranteed. Made in USA & American Owned

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel daily, preferably with a meal or as directed by your healthcare professional.

Formula

Lutein is an antioxidant that may play an important role in eye and skin health.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.

General Statements

Questions/Comments Call 1-800-682-9862

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein 15 mg by Nature's Blend label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein 15 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein 15 mg by Nature's Blend

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein Esters

No known
interactions
15 mg per serving Form: Marigold flower extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein Esters monograph & interactions

Zeaxanthin Esters

Interacts with
86 drugs
600 mcg per serving Form: Marigold flower extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin Esters monograph & interactions

Other (inactive) ingredients: Rice Bran Oil, Gelatin, Glycerin, Sunflower Oil, Bees Wax, Soy Lecithin, Caramel, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein 15 mg by Nature's Blend Drug Interactions

Want to check YOUR meds against Lutein 15 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin Esters 86

Individual Drug Interactions

The ingredients in Lutein 15 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein 15 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin Esters

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein 15 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin Esters1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin Esters full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein 15 mg, from the product label.

Nature's Blend

See all Nature's Blend products
Name
National Vitamin Company
City
Casa Grande
State
AZ
ZipCode
85122
Phone Number
1-800-682-9862
Web Address
www.nationalvitamin.com
Pharmacist Counseling Corner

Lutein 15 mg by Nature's Blend: Common Questions

Does Lutein 15 mg by Nature's Blend interact with any medications?
Yes. Based on its ingredients, Lutein 15 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein 15 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
Both ingredients are rated likely safe in pregnancy and lactation. However, most of the safety data is for lutein and zeaxanthin from food, not concentrated supplements. Since the data on supplement doses during these times is limited, talk with your doctor or pharmacist to decide what's right for you.
What does lutein actually do?
Lutein is a carotenoid — a plant pigment that builds up in the macula, the sharp-vision part of your eye. It may help protect against age-related macular degeneration and cataracts, though the evidence is still developing.
Can I take this if I'm on medication for diabetes?
That depends on your specific medication. Zeaxanthin in this product may theoretically increase the risk of low blood sugar when combined with antidiabetes drugs — a Moderate concern. Check your exact medication through the tool on this page, and talk with your doctor or pharmacist before starting.
What are the inactive ingredients, and are there fillers?
The softgel contains rice bran oil, gelatin, glycerin, sunflower oil, beeswax, soy lecithin, caramel, and purified water. These are the inactive ingredients that give the capsule its form and help deliver the active compounds — they're standard in softgel products.
Are there any side effects?
Both lutein esters and zeaxanthin esters are generally well tolerated. Lutein at doses up to 20 mg daily hasn't resulted in reported adverse effects. No adverse effects have been reported for zeaxanthin at typical supplement doses either.
Does this actually work for cataracts or macular degeneration?
The evidence rates both lutein and zeaxanthin as possibly effective for these conditions — meaning there's promise, but the science isn't conclusive yet. Your eye doctor can tell you whether this supplement makes sense for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein 15 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein 15 mg label
Go deeper

The Full Monographs Behind Lutein 15 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein 15 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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