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Dietary supplement

Lutein Zeaxanthin Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

Lutein Zeaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein Zeaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein Zeaxanthin is a dietary supplement by Progressive Professional from Progressive Laboratories with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin Isomers. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains 2 active ingredients: lutein and zeaxanthin isomers. Both are carotenoids — plant pigments your eyes naturally use to filter light and protect the macula (the central part of the retina that lets you see fine detail).

You'll find them together in foods like leafy greens, but this product delivers them in concentrated form. The inactive ingredients are safflower oil, bone gelatin, sunflower oil, glycerin, purified water, yellow beeswax, and sunflower lecithin — all there to hold the formula together and keep it stable in the softgel capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye health and macular protection.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

For age-related macular degeneration (AMD), both lutein and zeaxanthin are rated possibly effective — the research suggests they may help, but it's not definitive. For cataracts, lutein is also rated possibly effective.

For other conditions listed — retinitis pigmentosa, retinopathy of prematurity, and bronchopulmonary dysplasia — the evidence doesn't support benefit. Zeaxanthin has also been studied for age-related cognitive decline, Alzheimer disease, asthma, and breast cancer, but the evidence for those isn't reliable enough to say one way or the other.

The bottom line: this product may help protect your central vision as you age, but the science isn't ironclad. If you're taking it for AMD or cataract prevention, talk it over with your eye doctor to see if it fits your individual situation.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from foods and typical supplement doses is generally well tolerated — studies show doses up to 20 mg daily haven't caused adverse effects. Zeaxanthin is also generally well tolerated at typical supplement doses.

Both are rated likely safe in pregnancy and lactation, but here's the nuance: lutein is naturally in breast milk, and while lower amounts are fine, safety of higher supplement doses hasn't been well studied. The same caution applies to zeaxanthin in pregnancy and breastfeeding — food sources are fine, but concentrated supplements haven't been studied enough.

If you're pregnant or nursing, talk with your doctor or pharmacist before starting this product to make sure the dose is right for you.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (medication to control blood sugar), check with your pharmacist before adding this product. Zeaxanthin has shown blood-sugar-lowering effects in animal studies, which could theoretically increase the risk of low blood sugar (hypoglycemia) when combined with your medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a reasonable choice if you're concerned about age-related vision loss and want to add lutein and zeaxanthin — both are possibly effective for AMD and cataracts. But before you start, check your blood sugar medications with your pharmacist, since zeaxanthin may theoretically lower blood sugar.

If you're pregnant, nursing, or take antidiabetes drugs, confirm it's okay with your own doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein Zeaxanthin, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821047003
Net contents 30 Softgel Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261938
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
1 Softgel Capsule(s)
Servings per container
30
UPC/BARCODE
351821047003
IngredientAmount% DV
Lutein20 mg--
Zeaxanthin Isomers4 mg--

Other ingredients: Safflower Oil, Bone Gelatin, Sunflower Oil, Glycerin, purified Water, yellow Beeswax, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: One softgel capsule daily, preferably with a meal, or more, as directed by a health care professional.

Precautions

Sold only for dispensing by a licensed health professional.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of the reach of children.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to daisy-like flowers.

Discontinue use and consult your doctor if any adverse reactions occur.

Brand IP Statement(s)

Lutemax is a registered trademark of Omni Active Health Technologies, LTD.

Progressive Professional from Progressive Laboratories

Formulation

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Non-GMO Gluten free

Seals/Symbols

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Formula

Featuring Lutemax 2020

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein Zeaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
20 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin Isomers

Interacts with
86 drugs
4 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin Isomers monograph & interactions

Other (inactive) ingredients: Safflower Oil, Bone Gelatin, Sunflower Oil, Glycerin, Purified Water, Yellow Beeswax, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against Lutein Zeaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin Isomers 86

Individual Drug Interactions

The ingredients in Lutein Zeaxanthin interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein Zeaxanthin interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin Isomers

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein Zeaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin Isomers1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin Isomers full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein Zeaxanthin, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories: Common Questions

Does Lutein Zeaxanthin by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, Lutein Zeaxanthin has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein Zeaxanthin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my macular degeneration?
Both lutein and zeaxanthin are rated possibly effective for age-related macular degeneration (AMD), which means the research suggests they may help — but it's not proven beyond doubt. Your eye doctor is the best person to tell you if this specific product makes sense for your vision.
Is it safe to take if I'm pregnant or breastfeeding?
Both ingredients are rated likely safe in pregnancy and lactation, but the caution is real: while food sources are fine, concentrated supplement doses haven't been studied well enough in pregnancy or while breastfeeding. Talk with your doctor or pharmacist before starting it — they can give you personalized advice based on your situation.
What's the difference between lutein and zeaxanthin?
Both are carotenoids that protect your eyes, and they're often found together in green leafy vegetables. They work together in the macula (the central part of your retina) to filter harmful light. This product gives you both in one softgel.
Are there any side effects?
Lutein and zeaxanthin are both generally well tolerated at typical supplement doses. Studies show lutein at doses up to 20 mg daily hasn't caused adverse effects. No adverse effects have been reported for zeaxanthin at standard doses either.
Will this help with cataracts?
Lutein is rated possibly effective for cataracts, meaning the research is promising but not definitive. Zeaxanthin's effectiveness for cataracts hasn't been rated in our data. If you're concerned about cataract risk or progression, ask your eye doctor whether this supplement fits into your prevention or management plan.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein Zeaxanthin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein Zeaxanthin label
Go deeper

The Full Monographs Behind Lutein Zeaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein Zeaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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