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Dietary supplement

Lutigold Lutein 20 mg Ingredients & Drug Interactions

by Puritan's Pride Premium

Lutigold Lutein 20 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutigold Lutein 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutigold Lutein 20 mg is a dietary supplement by Puritan's Pride Premium with 1 active ingredient. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutigold Lutein 20 mg by Puritan's Pride Premium

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutigold Lutein 20 mg by Puritan's Pride Premium — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutigold Lutein 20 mg by Puritan's Pride Premium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Lutigold(TM) Lutein” is listed as a grouped ingredient — the label gives one combined amount (20 mg) without saying how much of each component you get.

This softgel contains one active ingredient: zeaxanthin (delivered as part of the proprietary Lutigold blend). Zeaxanthin is a carotenoid pigment found naturally in leafy greens and some other plant foods; it concentrates in the eye, particularly the macula, the area responsible for sharp central vision.

The softgel is filled with safflower oil, gelatin, vegetable glycerin, and yellow beeswax—all inactive ingredients that help deliver and stabilize the zeaxanthin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports eye health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Zeaxanthin is rated "Insufficient Reliable Evidence To Rate" for Cataracts, Glaucoma, Asthenopia (eye strain), Macular telangiectasia type 2.

Zeaxanthin is rated Possibly Effective for age-related macular degeneration (AMD), a progressive condition affecting central vision in older adults. For other conditions listed in our data—age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia—the evidence is insufficient to rate whether it works.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin is generally well tolerated at typical supplement doses. In pregnancy, dietary amounts from food are fine, but the safety of concentrated supplements hasn't been well studied; use caution and talk it over with your doctor or pharmacist.

The same goes for breastfeeding—food sources are safe, but concentrated supplement safety isn't well established, so you'll want to discuss it with your healthcare provider first.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs—including insulin, metformin, sulfonylureas, or any other diabetes medication—check your specific prescriptions with your doctor or pharmacist before taking this product. Zeaxanthin may theoretically lower blood sugar, which could raise the risk of hypoglycemia when combined with diabetes medicine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you're concerned about age-related macular degeneration, zeaxanthin is a reasonable candidate to consider. If you take diabetes medications, though, check your exact drugs with your doctor or pharmacist before starting—the risk of low blood sugar is the main thing to watch.

For any other health question or to weigh this against other options for your eyes, talk it over with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutigold Lutein 20 mg, straight from the product label.

Brand Puritan's Pride Premium
Net contents 60 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25942
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutigold Lutein 20 mg by Puritan's Pride Premium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
IngredientAmount% DV
Contains Zeaxanthin800 mcg--
Lutigold(TM) Lutein20 mg--

Other ingredients: Safflower Oil, Gelatin, Vegetable Glycerin, yellow Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No Artificial Color, Flavor or Sweetener,No Preservatives, No Sugar, No Starch, No Milk,No Lactose, No Soy, No gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel up to two times daily, preferably with meals.

Formula

Natural Carotenoid

Naturally Contains Zeaxanthin

Precautions

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

General

Item #004901

General Statements

Supports Eye Health

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutigold Lutein 20 mg by Puritan's Pride Premium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutigold Lutein 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutigold Lutein 20 mg by Puritan's Pride Premium

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Lutigold(TM) Lutein

No known
interactions
20 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutigold(TM) Lutein monograph & interactions

Other (inactive) ingredients: Safflower Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutigold Lutein 20 mg by Puritan's Pride Premium Drug Interactions

Want to check YOUR meds against Lutigold Lutein 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Lutigold Lutein 20 mg interact with 86 drugs. Click any drug to see the details.

0 of the 1 ingredient in Lutigold Lutein 20 mg interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutigold Lutein 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Lutigold Lutein 20 mg, from the product label.

Puritan's Pride Premium

See all Puritan's Pride Premium products
Web Address
www.puritan.com
Pharmacist Counseling Corner

Lutigold Lutein 20 mg by Puritan's Pride Premium: Common Questions

Does Lutigold Lutein 20 mg by Puritan's Pride Premium interact with any medications?
Yes. Based on its ingredients, Lutigold Lutein 20 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutigold Lutein 20 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is zeaxanthin the same as lutein?
No—they're related carotenoids that work together in the eye, but they're different compounds. This product delivers zeaxanthin as part of the Lutigold blend; both are naturally present in leafy greens and other plant foods.
Can I take this if I'm pregnant or breastfeeding?
Zeaxanthin from food is safe during pregnancy and breastfeeding. However, concentrated supplement safety hasn't been well studied in either situation. Talk with your doctor or pharmacist about whether to take this product while pregnant or nursing—they can help you weigh the evidence for your individual situation.
Does zeaxanthin actually prevent AMD, or just help once you have it?
Our data rates it Possibly Effective for AMD, but the evidence doesn't clearly establish whether it prevents it from developing in the first place. If you're worried about eye health or already have AMD, that's a question for your eye doctor.
What are the side effects?
No adverse effects are listed in our data for zeaxanthin at typical supplement amounts. It's generally well tolerated.
How much lutein is in this?
The product is labeled Lutein 20 mg and delivers zeaxanthin as part of the Lutigold proprietary blend. The label lists the total amount; your pharmacist can clarify the exact ratio of zeaxanthin to other blend components if that matters for your choice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutigold Lutein 20 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutigold Lutein 20 mg label
Go deeper

The Full Monographs Behind Lutigold Lutein 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutigold Lutein 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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