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Dietary supplement

Natural Chlorella 500 mg Ingredients & Drug Interactions

by Puritan's Pride Premium

Natural Chlorella 500 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Chlorella 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Chlorella 500 mg is a dietary supplement by Puritan's Pride Premium with 1 active ingredient. Its ingredients are commonly taken for general nutrition and 'detox' support, immune support, liver and kidney support.Based on those ingredients, 339 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorella, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Chlorella 500 mg by Puritan's Pride Premium

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Chlorella 500 mg by Puritan's Pride Premium — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Chlorella 500 mg by Puritan's Pride Premium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Chlorella, Natural” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This product contains one active ingredient: chlorophyll, a naturally occurring green pigment from plants, provided at 500 mg per tablet. The remaining ingredients — cellulose, acacia gum, silica, and magnesium stearate — are inactive binders and fillers that hold the tablet together.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Chlorophyll product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Chlorophyll's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“Health and wellness support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence we hold is insufficient to rate chlorophyll for genital herpes, wound healing, herpes zoster (shingles), nonmelanoma skin cancer, or pancreatitis. That means the data on file isn't robust enough to say whether it works for these uses.

If you're considering chlorophyll for any of these conditions, talk with your doctor about whether there's stronger evidence elsewhere or whether other options might be better studied.

The evidence, ingredient by ingredient Chlorella Chlorophyll

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chlorophyll is generally well tolerated in short-term use, though high-quality safety data are limited. The most common oral side effect is photosensitization — increased sensitivity to sunlight that can cause blistering or skin reactions.

Rarely, a condition called pseudoporphyria (easily traumatized blisters on the hands) has been reported after taking chlorophyll by mouth. During pregnancy, there isn't enough reliable safety information, so it's best avoided unless your doctor advises otherwise.

Safety during breastfeeding is also unknown, so avoid it unless your doctor says it's okay. If you're pregnant, planning pregnancy, or breastfeeding, check with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Chlorella Chlorophyll

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chlorophyll.
  • The most serious interaction on file is rated Moderate.
  • For scale: 337 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take photosensitizing drugs (medications that increase your skin's sensitivity to sun) or methotrexate. Chlorophyll may add to the skin-sensitizing effects of the first group and may slow clearance of the second.

No interactions are documented for the natural chlorella component itself.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Chlorophyll from this product may interact with photosensitizing drugs and methotrexate, so if you take either, clear it with your doctor or pharmacist first. The evidence we hold doesn't yet support its use for herpes, wound healing, shingles, skin cancer, or pancreatitis.

It's generally well tolerated short-term, but avoid it in pregnancy and breastfeeding unless your healthcare provider says otherwise. Run your medications through the checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Chlorella 500 mg, straight from the product label.

Brand Puritan's Pride Premium
Barcode (UPC) 074312135927
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286108
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Chlorella 500 mg by Puritan's Pride Premium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
60
UPC/BARCODE
074312135927
IngredientAmount% DV
Chlorophyll20 mg--
Chlorella, Natural1000 mg--

Other ingredients: Cellulose, Acacia Gum, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports health and wellness

Vegetarian Dietary Supplement

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

Puritan's Pride Premium supplements are produced from the finest raw materials under stringent quality control standards. Our state-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

Formula

Source of chlorophyll and plant enzymes

FDA Statement of Identity

Vegetarian Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) tablets three times daily, preferably with meals.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

To reorder item #3592 www.puritan.com 1-800-645-1030

Brand IP Statement(s)

Copyright 2013 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Chlorella 500 mg by Puritan's Pride Premium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Chlorella 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Chlorella 500 mg by Puritan's Pride Premium

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Chlorella, Natural

Interacts with
337 drugs
1000 mg per serving Form: Chlorella vulgaris

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies sugges...

Chlorella, Natural monograph & interactions

Other (inactive) ingredients: Cellulose, Acacia Gum, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Chlorella 500 mg by Puritan's Pride Premium Drug Interactions

Want to check YOUR meds against Natural Chlorella 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
339Drugs
339 Moderate

Ingredients driving the most interactions

Chlorella, Natural 337

Individual Drug Interactions

The ingredients in Natural Chlorella 500 mg interact with 339 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Chlorella 500 mg interact with drugs. Each result below shows which ingredient is responsible. Chlorella, Natural

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Chlorella 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorella, Natural2 drug types · 337 drugs

Photosensitizing Drugs

Theoretically, chlorella might have additive effects with photosensitizing drugs.
Chlorella has been reported to cause photosensitization. In five case reports, patients who had ingested chlorella exhibited swelling followed by erythematopurpuric lesions on sun-exposed areas of the body. Theoretically, concomitant use with photosensitizing drugs may exacerbate effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, chlorella might reduce the clinical effects of warfarin.
Chlorella contains significant amounts of vitamin K. There is at least one case report of warfarin therapy becoming sub-therapeutic after initiation of chlorella supplements.

Likelihood Possible Evidence D
Chlorella, Natural full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Chlorella 500 mg, from the product label.

Puritan's Pride Premium

See all Puritan's Pride Premium products
Name
Puritan's Pride, Inc.
City
Holbrook
State
NY
ZipCode
11741
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Natural Chlorella 500 mg by Puritan's Pride Premium: Common Questions

Does Natural Chlorella 500 mg by Puritan's Pride Premium interact with any medications?
Yes. Based on its ingredients, Natural Chlorella 500 mg has a known interaction with 339 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Chlorella 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does chlorophyll actually do in this supplement?
Chlorophyll is a natural green pigment from plants. The product claims it may help with conditions like genital herpes, wound healing, shingles, skin cancer, and pancreatitis — but the evidence we hold is insufficient to say whether it actually works for any of these.
Can I take this if I'm pregnant or breastfeeding?
No — avoid it during pregnancy because there isn't enough reliable safety information. During breastfeeding, safety is unknown, so avoid it unless your doctor advises otherwise. If you're in either situation, talk with your doctor or pharmacist before starting.
What side effects should I watch for?
The most common side effect is photosensitization — increased sensitivity to sunlight that can cause blistering or skin reactions. Rarely, a serious condition called pseudoporphyria (easily traumatized blisters on the hands) has been reported. If you notice unusual blistering or a rash after sun exposure, stop the product and talk with your doctor.
Is there anything else in this tablet besides chlorophyll?
The active ingredient is chlorophyll. The tablet also contains inactive ingredients — cellulose, acacia gum, silica, and magnesium stearate — which are binders and fillers that hold it together.
Do I need to worry about sun exposure while taking this?
Yes — chlorophyll can make your skin more light-sensitive, so be cautious in the sun and consider extra sun protection. If you're already taking a photosensitizing drug, the risk is higher. Talk with your doctor or pharmacist about your sun exposure habits.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Chlorella 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Chlorella 500 mg label
Go deeper

The Full Monographs Behind Natural Chlorella 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chlorella

Interacts with 337 drugs

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies suggest possible benefits for cholesterol, blo...

Read the full Chlorella monograph → Herb & supplement monograph

Chlorophyll

Interacts with 337 drugs

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...

Read the full Chlorophyll monograph →
Sources

Sources & How We Checked

Natural Chlorella 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chlorophyll 5 references
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  3. Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

See these in context on the Chlorophyll monograph →

Chlorella 13 references
  1. Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York, NY: William Morrow and Co., 1999.
  2. Ng TP, Tan WC, Lee YK. Occupational asthma in a pharmacist induced by chlorella, a unicellular algae preparation. Resp Med 1994;88:555-7. PubMed
  3. Jitsukawa K, Suizu R, Hidano A. Chlorella photosensitization. New phytophotodermatosis. Int J Dermatol 1984;23:263-8. PubMed
  4. Merchant RE, Carmack CA, Wise CM. Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 2000;14:167-73.
  5. Merchant RE, Rice CD, Young HF. Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects on immunocompetence, quality of life, and survival. Phytother Res 1990;4:220-31.
  6. Halperin SA, Smith B, Nolan C, et al. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ 2003;169:111-7..
  7. Ohtake, T., Negishi, K., Okamoto, K., Oka, M., Maesato, K., Moriya, H., and Kobayashi, S. Manganese-induced Parkinsonism in a patient undergoing maintenance hemodialysis. Am J Kidney Dis 2005;46(4):749-753. PubMed
  8. Ng, T. P., Tan, W. C., and Lee, Y. K. Occupational asthma in a pharmacist induced by Chlorella, a unicellular algae preparation. Respir.Med. 1994;88(7):555-557. PubMed
  9. Ohkawa, S., Yoneda, Y., Ohsumi, Y., and Tabuchi, M. [Warfarin therapy and chlorella]. Rinsho Shinkeigaku 1995;35(7):806-807.
  10. Azocar J, Diaz A. Efficacy and safety of chlorella supplementation in adults with chronic hepatitis C virus infection. World J Gastroenterol 2013;19(7):1085-90. PubMed
  11. Panahi Y, Badeli R, Karami GR, Badeli Z, Sahebkar A. A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder. Complement Ther Med 2015;23(4):598-602. PubMed
  12. Nakano S, Takekoshi H, Nakano M. Chlorella pyrenoidosa supplementation reduces the risk of anemia, proteinuria and edema in pregnant women. Plant Foods Hum Nutr 2010;65(1):25-30. PubMed
  13. Yavasoglu I, Turgutkaya A, Bolaman Z. Chlorella-induced thrombocytopenia. Sao Paulo Med J 2018;136(6):602-3. PubMed

See these in context on the Chlorella monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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