Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Mac-o-Power Plus Ingredients & Drug Interactions

by North American Herb & Spice

Mac-o-Power Plus label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mac-o-Power Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mac-o-Power Plus is a dietary supplement by North American Herb & Spice with 3 active ingredients. Its ingredients are commonly taken for low libido and sexual function, energy and stamina, menopause symptoms.Based on those ingredients, 290 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Purple Corn Extract, Raw. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mac-o-Power Plus by North American Herb & Spice

Ask about any prescription or over-the-counter medication and we check it for interactions with Mac-o-Power Plus by North American Herb & Spice — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mac-o-Power Plus by North American Herb & Spice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Mac-o-Power Plus contains three active ingredients: Purple Maca Root Extract, Purple Corn Extract (Raw), and Yacon Root Extract (Raw). The product is formulated as a liquid and contains no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports healthy hormone system and energy response.
  • We looked for evidence on: Age-related testosterone deficiency, Postmenopausal conditions, Sexual desire, Fatigue, Athletic performance, hormonal balance — and 1 related terms.
  • The closest evidence on file: Corn Silk is rated "Insufficient Reliable Evidence To Rate" for Fatigue (Natural Medicines).
  • Also on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chronic fatigue syndrome (CFS), Fatigue, Postmenopausal conditions, and more.

The evidence supporting these ingredients isn't established in the data we hold. Purple Maca Root Extract has been studied for amenorrhea (missed periods), sexual dysfunction linked to antidepressants, athletic performance, anemia, and osteoporosis — but the research is too limited or unreliable to rate it as effective for any of these uses.

We have no effectiveness data on file for Purple Corn Extract, Raw or Yacon Root Extract, Raw.

The evidence, ingredient by ingredient Maca Corn Silk

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Purple Maca Root Extract is generally well tolerated as a food, though long-term safety in supplement amounts hasn't been studied. Fresh, uncooked maca may cause stomach pain in some people.

The safety data advises against using this product during pregnancy or while breastfeeding — there isn't enough reliable information. We hold no safety data for Purple Corn Extract, Raw or Yacon Root Extract, Raw.

Side effects, ingredient by ingredient Maca Corn Silk

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Corn Silk.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 290 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

No interactions are documented in our data for the ingredients we could check. However, we hold no interaction data for Purple Corn Extract, Raw or Yacon Root Extract, Raw.

Check your exact medications with the search tool on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're considering Mac-o-Power Plus for general wellness, know that the evidence for its active ingredients is limited. Pregnant or breastfeeding women should avoid it.

Talk to your pharmacist about whether this product fits your health goals and whether any of your medications might be affected — even though we found no documented interactions for the ingredients we could check.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mac-o-Power Plus, straight from the product label.

Brand North American Herb & Spice
Barcode (UPC) 635824002789
Net contents 2 Fluid Ounce(s); 60 Milliliter(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269806
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mac-o-Power Plus by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
10 Drop(s)
Servings per container
172
UPC/BARCODE
635824002789
IngredientAmount% DV
Proprietary Blend0 NP--
Purple Maca Root Extract0 NP--
Purple Corn Extract, Raw0 NP--
Yacon Root Extract, Raw0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a natural food take 10 or more drops under the tongue twice daily. Add to milk, yogurt, or juice.

Formula

Mac-o-Power Plus is the only fresh, raw mountain maca extract available. This is the purple maca, which is the most powerful type, along with purple corn and yacon root, all from the Andes Mountains.

Mountain purple maca & purple corn

Formulation

These are the most powerful plants and vegetables known. This is raw liquid power.

Supports a healthy hormone system Supports a healthy energy response

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mac-o-Power Plus by North American Herb & Spice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mac-o-Power Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mac-o-Power Plus by North American Herb & Spice

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container172 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving
Interaction report

Mac-o-Power Plus by North American Herb & Spice Drug Interactions

Want to check YOUR meds against Mac-o-Power Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
290Drugs
290 Moderate

Ingredients driving the most interactions

Purple Corn Extract, Raw 290

Individual Drug Interactions

The ingredients in Mac-o-Power Plus interact with 290 drugs. Click any drug to see the details.

1 of the 3 ingredients in Mac-o-Power Plus interact with drugs. Each result below shows which ingredient is responsible. Purple Corn Extract, Raw

Each ingredient & the kinds of drugs it affects

For each ingredient in Mac-o-Power Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Purple Corn Extract, Raw5 drug types · 290 drugs

Antidiabetes Drugs

Theoretically, taking corn silk with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research in diabetic mice shows that taking corn silk extract lowers fasting blood glucose levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.
Clinical research in both hypertensive and normotensive adults shows that taking corn silk extract lowers systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Corticosteroids

Taking corn silk with corticosteroids might increase the risk of hypokalemia.
Clinical research shows that taking corn silk extract increases the urinary excretion of potassium.

Likelihood Possible Evidence D
Diuretic Drugs

Taking corn silk with diuretic drugs might increase the risk of adverse effects such as hyponatremia and hypokalemia.
Clinical research shows that taking corn silk extract increases urine volume and promotes the urinary excretion of sodium and potassium. Some patients may require electrolyte supplementation.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, suddenly stopping, starting, or changing corn silk treatment may alter the effects of warfarin.
Corn silk contains vitamin K. Individuals taking warfarin should consume a consistent daily amount of corn silk to maintain consistent anticoagulation.

Likelihood Likely Evidence D
Purple Corn Extract, Raw full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mac-o-Power Plus, from the product label.

North American Herb & Spice

See all North American Herb & Spice products
Name
North American Herb & Spice
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-243-5242
Web Address
www.oreganol.com
Pharmacist Counseling Corner

Mac-o-Power Plus by North American Herb & Spice: Common Questions

Does Mac-o-Power Plus by North American Herb & Spice interact with any medications?
Yes. Based on its ingredients, Mac-o-Power Plus has a known interaction with 290 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mac-o-Power Plus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough reliable information about using this product during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What is maca root used for?
Maca root has been studied for missed periods, sexual dysfunction related to antidepressants, athletic performance, anemia, and bone health. The research is too limited to say it's effective for any of these, though.
Could this product upset my stomach?
Fresh, uncooked maca may cause stomach pain in some people. If you experience that, talk with your pharmacist about whether to continue.
Has the long-term safety of this product been studied?
Purple Maca Root Extract is generally well tolerated as a food, but long-term safety in supplement amounts hasn't been well studied. We also have no safety data on file for the other two ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mac-o-Power Plus is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mac-o-Power Plus label
Go deeper

The Full Monographs Behind Mac-o-Power Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Corn Silk

Interacts with 290 drugs

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should...

Read the full Corn Silk monograph →
Sources

Sources & How We Checked

Mac-o-Power Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Corn Silk 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
  4. Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

See these in context on the Corn Silk monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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