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Dietary supplement

Maitake Mushroom Extract Powder Ingredients & Drug Interactions

by Z Natural Foods

Maitake Mushroom Extract Powder label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake Mushroom Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake Mushroom Extract Powder is a dietary supplement by Z Natural Foods with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake Mushroom Extract Powder by Z Natural Foods

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake Mushroom Extract Powder by Z Natural Foods — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maitake Mushroom Extract Powder by Z Natural Foods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: maitake extract, a concentrated form of compounds from the maitake mushroom. The powder also includes maltodextrin as an inactive ingredient (a starch used to bind and flow the powder).

Maitake has been studied for its polysaccharide content, which appears to be the source of its effects on blood pressure and blood sugar.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune system support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Chemotherapy-induced leukopenia, Chronic fatigue syndrome (CFS), HIV/AIDS, infection resistance, immune function — and 1 related terms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced leukopenia, Chronic fatigue syndrome (CFS), HIV/AIDS.

The evidence for maitake mushroom is incomplete. We hold insufficient reliable evidence to rate it for allergic rhinitis (hay fever), chemotherapy-induced anemia, laryngeal cancer, and chemotherapy-induced diarrhea.

That means the data we have isn't robust enough to say whether it works for these uses. If you're considering maitake for any of these purposes, talk with your doctor about what the current research actually supports.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when used as food, though concentrated supplement safety hasn't been fully studied. The most common side effects are gastrointestinal — diarrhea and stomach pain (epigastric discomfort) — reported by a small number of trial participants.

One patient experienced a rash and itching after two doses, which cleared on its own without treatment. Not enough safety data exists for concentrated maitake supplements during pregnancy or breastfeeding; the safety data advises against use in both situations.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on warfarin (Coumadin) or any other blood thinner — maitake may boost their effect and raise bleeding risk. Also flag any blood pressure medication or diabetes drug you're taking, because maitake can lower both and may push them too far.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake mushroom extract may be worth considering if you're curious about mushroom supplements and have no interactions with blood pressure, diabetes, or blood-thinning medications. If you take any of those drugs — or warfarin in particular — you'll need to clear this with your doctor or pharmacist first, because the interaction risks are real.

Pregnant or breastfeeding? The safety data isn't there yet, so check with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake Mushroom Extract Powder, straight from the product label.

Brand Z Natural Foods
Barcode (UPC) 793888831346
Net contents 1 Pound(s); 454 Gram(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 299859
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake Mushroom Extract Powder by Z Natural Foods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.8 Gram(s)
Maximum serving Sizes:
2.8 Gram(s)
Servings per container
162
UPC/BARCODE
793888831346
IngredientAmount% DV
Maitake Extract2.66 Gram(s)--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Organic

Non GMO Gluten free Chemical free

Vegan

USDA Organic

Orgin: Packaged with Care in Florida, USA.

Certified Organic: Baystate Organic Certifiers

Seals/Symbols

USDA Organic

Formula

Our Maitake Mushroom Extract Powder is a 10:1 ratio containing a minimum of 30% polysaccharides. Kown as the "King of Mushrooms, Maitake Mushrooms are rich in beta-glucans, which support the immune system. Famous for its one-of-a-kind taste and health benefits, Maitake Mushrooms are a natural source of vital minerals such as magnesium and potassium, as well as B vitamins and amino acids.

Suggested/Recommended/Usage/Directions

Suggested use: 1 teaspoon daily in soup, smoothie, or on a salad.

Precautions

California Prop 65 Warning: Cancer and reproductive harm - www.P65Warnings.ca.gov/food

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake Mushroom Extract Powder by Z Natural Foods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake Mushroom Extract Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake Mushroom Extract Powder by Z Natural Foods

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.8 Gram(s) Dosage formPowder Servings per container162 Amounts shown are per serving.

Maitake Extract

Interacts with
260 drugs
2.66 Gram(s) per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake Mushroom Extract Powder by Z Natural Foods Drug Interactions

Want to check YOUR meds against Maitake Mushroom Extract Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake Extract 260

Individual Drug Interactions

The ingredients in Maitake Mushroom Extract Powder interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake Mushroom Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Maitake Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake Mushroom Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake Extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake Mushroom Extract Powder, from the product label.

Z Natural Foods

See all Z Natural Foods products
Name
Z Natural Foods
Street Address
5407 N Haverhill Rd Ste 336
City
West Palm Beach
State
FL
ZipCode
33407
Web Address
www.ZNaturalFoods.com
Pharmacist Counseling Corner

Maitake Mushroom Extract Powder by Z Natural Foods: Common Questions

Does Maitake Mushroom Extract Powder by Z Natural Foods interact with any medications?
Yes. Based on its ingredients, Maitake Mushroom Extract Powder has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake Mushroom Extract Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Maitake can lower blood pressure, so combining it with antihypertensive drugs risks your pressure dropping too steeply. Check with your doctor or pharmacist before adding this — they can see your current medications and advise whether it's safe for you.
What if I'm taking diabetes medication?
Maitake appears to lower blood sugar, which means pairing it with diabetes drugs could drop your blood sugar too low (hypoglycemia). Talk with your doctor or pharmacist before starting — they'll know whether this product works with your current regimen.
What are the most common side effects?
Stomach upset is the main one — diarrhea and stomach pain were reported by a small number of trial participants. One person developed a rash and itching after two doses, but it resolved on its own.
Is it safe during pregnancy or breastfeeding?
The safety data advises against concentrated maitake supplements in both pregnancy and breastfeeding because there isn't enough research yet. Talk with your doctor or pharmacist about whether this is right for you.
Does maitake actually work for what it's marketed to do?
The evidence we hold is incomplete. We have insufficient reliable data to rate maitake for hay fever, chemotherapy-related anemia, throat cancer, or chemotherapy-related diarrhea. If you're considering it for one of those uses, ask your doctor what the current research actually shows.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake Mushroom Extract Powder label
Go deeper

The Full Monographs Behind Maitake Mushroom Extract Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake Mushroom Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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