Interactions on record — worth a quick check against your medications. Based on 8 of 11 ingredients. Check your meds →
Dietary supplement

MaitakeGold 404 Patented Beta-Glucan Extract Ingredients & Drug Interactions

by Natural Factors

MaitakeGold 404 Patented Beta-Glucan Extract label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MaitakeGold 404 Patented Beta-Glucan Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MaitakeGold 404 Patented Beta-Glucan Extract is a dietary supplement by Natural Factors with 11 active ingredients. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 997 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Poria cocos, Ganoderma lucidum, Hericium erinaceus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “Multi Mycelia Blend” is a proprietary blend — the label gives one combined amount (85 mg) without saying how much of each component you get.

MaitakeGold 404 contains 11 ingredients, of which we have data on nine. The active components are medicinal mushroom extracts: shiitake (Lentinula edodes), lion's mane (Hericium erinaceus), poria (Poria cocos), maitake (Grifola frondosa), agaricus, reishi (Ganoderma lucidum), turkey tail (Coriolus versicolor), cordyceps (Cordyceps sinensis), and the proprietary MaitakeGold 404 extract — all known for their beta-glucan polysaccharide content, a type of immune-supporting compound found in fungi.

The product also lists a Multi Mycelia Blend and includes Schizophyllum commune and Tremella fuciformis, though we hold no interaction data for the last two. Inactive ingredients include rice powder, gelatin capsule, and magnesium stearate (a flow agent).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune support.
  • We looked for evidence on: Common cold, Coronavirus disease 2019 (COVID-19), Allergic rhinitis (hay fever), Asthma, Bronchitis, Chemotherapy-induced leukopenia — and 4 related terms.
  • The closest evidence on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Coronavirus disease 2019 (COVID-19) (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), HIV/AIDS, Chemotherapy-induced leukopenia, Coronavirus disease 2019 (COVID-19).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Asthma, Hepatitis B.

The evidence supporting these mushroom extracts remains limited. Most uses are rated insufficient evidence to know whether they work — this includes claims around cancer, cognitive function, athletic performance, and chemotherapy side effects.

Turkey tail alone carries a rating of possibly effective for cancer, based on animal and some clinical research. Reishi is rated possibly ineffective for high cholesterol.

Shiitake is rated possibly ineffective for dental plaque. For all other conditions listed in the data — allergies, chronic fatigue, diabetes management, and others — the evidence simply isn't established well enough to make a call one way or the other.

The evidence, ingredient by ingredient Maitake Mushroom Shiitake Mushroom Lion's Mane Mushroom Poria Mushroom Agaricus Mushroom Reishi Mushroom Turkey Tail Mushroom Cordyceps

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These mushroom extracts are generally well tolerated when eaten as whole food, but safety data on concentrated supplements over the long term is limited. The most common side effects reported are gastrointestinal: stomach discomfort, bloating, diarrhea, nausea, and vomiting — usually mild and infrequent.

Raw shiitake can cause a distinctive skin rash called shiitake dermatitis with possible systemic symptoms, and people who handle mushrooms heavily may develop respiratory allergies. Agaricus supplements carry rare but serious risks including liver damage and interstitial lung disease (scarring of lung tissue); three cases of fatal liver failure have been reported in women with cancer taking agaricus alongside chemotherapy.

Reishi may cause dizziness. If you are pregnant or breastfeeding, the safety data are not sufficient — concentrated mushroom supplements should be avoided because there isn't enough information to know whether they're safe for your baby.

Talk with your doctor or pharmacist about whether this product is right for you in those situations.

Side effects, ingredient by ingredient Maitake Mushroom Shiitake Mushroom Lion's Mane Mushroom Poria Mushroom Agaricus Mushroom Reishi Mushroom Turkey Tail Mushroom Cordyceps

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 8 matched ingredients can interact with medications — Poria Mushroom, Maitake Mushroom, Cordyceps, Turkey Tail Mushroom, Shiitake Mushroom, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 997 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of the following: warfarin or other blood thinners (anticoagulant/antiplatelet drugs) — risk of increased bleeding; diabetes medications — risk of low blood sugar; blood pressure medications; medications that suppress your immune system; sedatives; anticholinergic or cholinergic drugs (used for nerve and muscle conditions); cyclophosphamide or tamoxifen (chemotherapy drugs); or any drug metabolized by CYP2D6 or CYP2C9 enzymes. No interactions are documented for Schizophyllum commune or Tremella fuciformis, which we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

MaitakeGold 404 is a multi-ingredient mushroom blend that carries real medication interactions, especially with blood thinners like warfarin, diabetes drugs, blood pressure medications, and immune suppressors. If you're on any prescription medication — particularly warfarin, diabetes treatments, blood pressure drugs, or immune-suppressing agents — check your exact medications with the tool on this page before starting.

Even if you're not on these, talk with your doctor or pharmacist first to make sure it's safe for your individual health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MaitakeGold 404 Patented Beta-Glucan Extract, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958043050
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 9403
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
068958043050
IngredientAmount% DV
Lentinula edodes0 NP--
Hericium erinaceus0 NP--
Poria cocos0 NP--
Grifola frondosa0 NP--
Schizophyllum commune0 NP--
Agaricus blazei0 NP--
Ganoderma lucidum0 NP--
Coriolus versicolor0 NP--
Cordyceps sinensis0 NP--
MaitakeGold 40415 mg--
Multi Mycelia Blend85 mg--
Tremella fuciformis0 NP--

Other ingredients: Rice powder, Gelatin Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: For daily immune support, take 1 capsule (15 mg) per day. For advanced immune support take 1 mg for every 2.2 pounds of body weight or as directed by a health professional.

Calculate: Body weight divided by 2.2, multiplied by 1 mg = dosage. e.g. 140 lb would equal 4 capsules per day. Best if taken on an empty stomach.

Precautions

Keep out of reach of children.

Sealed for your protection. Do not use if seal is broken.

Formulation

Contains no artificial preservatives, color or sweeteners; no corn, dairy, wheat or yeast.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

PRODUCT OF JAPAN

Dr. Michael Murray Recommended IMMUNE SUPPORT & CELLULAR HEALTH*

All Natural Factors products are manufactured in accordance with the Government of Canada's Good Manufacturing Practices (GMP), among the highest standards in the world.

Seals/Symbols

(recycle) Recyclable container.

ImmuneActive(TM) Certificate MaitakeGold Certified Bioactivity U.S. PATENT 5,854,404

Purity & Potency Guaranteed

General

R3

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

MaitakeGold 404(R) is a registered trademark of Tradeworks Group Inc.

Dr. Michael Murray recommends only MaitakeGold 404(R), the authentic patented* maitake mushroom formula of powerful immune-enhancing compounds developed by Dr. Hiroaki Nanba of Japan.* The "Certified Bioactivity" seal guarantees that each batch of MaitakeGold 404(R) is proven and certified to activate immune cellular response.* *U.S. Patent # 5,854,404

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MaitakeGold 404 Patented Beta-Glucan Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

MaitakeGold 404

Interacts with
260 drugs
15 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

MaitakeGold 404 monograph & interactions

Multi Mycelia Blend

85 mg per serving

Other (inactive) ingredients: Rice powder, Gelatin Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors Drug Interactions

Want to check YOUR meds against MaitakeGold 404 Patented Beta-Glucan Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
997Drugs
955 Moderate 42 Minor

Ingredients driving the most interactions

Poria cocos 417
Ganoderma lucidum 375
Hericium erinaceus 327
Lentinula edodes 312
MaitakeGold 404 260

Individual Drug Interactions

The ingredients in MaitakeGold 404 Patented Beta-Glucan Extract interact with 997 drugs. Click any drug to see the details.

8 of the 11 ingredients in MaitakeGold 404 Patented Beta-Glucan Extract interact with drugs. Each result below shows which ingredient is responsible. Poria cocos Ganoderma lucidum Hericium erinaceus Lentinula edodes MaitakeGold 404 Cordyceps sinensis Coriolus versicolor Agaricus blazei

Each ingredient & the kinds of drugs it affects

For each ingredient in MaitakeGold 404 Patented Beta-Glucan Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Poria cocos3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria cocos full monograph & interactions

Ganoderma lucidum3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Ganoderma lucidum full monograph & interactions

Hericium erinaceus3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Hericium erinaceus full monograph & interactions

Lentinula edodes2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Lentinula edodes full monograph & interactions

MaitakeGold 4043 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
MaitakeGold 404 full monograph & interactions

Cordyceps sinensis3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps sinensis full monograph & interactions

Coriolus versicolor4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Coriolus versicolor full monograph & interactions

Agaricus blazei1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus blazei full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MaitakeGold 404 Patented Beta-Glucan Extract, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors: Common Questions

Does MaitakeGold 404 Patented Beta-Glucan Extract by Natural Factors interact with any medications?
Yes. Based on its ingredients, MaitakeGold 404 Patented Beta-Glucan Extract has a known interaction with 997 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MaitakeGold 404 Patented Beta-Glucan Extract contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data aren't established well enough to say either way. The facts advise against concentrated mushroom supplements during pregnancy and breastfeeding because we don't have enough information. Talk with your doctor or pharmacist for personalized advice — they can help you decide what's right for you and your baby.
What side effects might I notice?
The most common ones are mild gastrointestinal issues: stomach discomfort, diarrhea, nausea, bloating, and vomiting. These tend to be infrequent and mild. Reishi may cause dizziness. Rare allergic reactions including rash have been reported.
Does this product actually work for anything?
Turkey tail is rated possibly effective for cancer based on some research. Most other uses — cognitive function, athletic performance, diabetes, chronic fatigue, allergies, and others — have insufficient evidence to know whether it works. The evidence just isn't there yet to make a solid claim.
Is this safe if I eat shiitake or other mushrooms as food?
Eating whole cooked mushrooms is generally safe. But this product is a concentrated supplement, and the safety data for concentrated doses isn't as strong as it is for food amounts. Your doctor or pharmacist can help you figure out whether the supplement dose is right for you.
What is beta-glucan and why is it in here?
Beta-glucan is a natural compound found in mushroom cell walls that's thought to support immune function. That's the main reason these extracts are included — they're all sources of beta-glucans.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MaitakeGold 404 Patented Beta-Glucan Extract label
Go deeper

The Full Monographs Behind MaitakeGold 404 Patented Beta-Glucan Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph →
Sources

Sources & How We Checked

MaitakeGold 404 Patented Beta-Glucan Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 135 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shiitake Mushroom 67 references
  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  7. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  8. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
  9. Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
  10. Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
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Lion's Mane Mushroom 6 references
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Poria Mushroom 3 references
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Maitake Mushroom 8 references
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Agaricus Mushroom 5 references
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Reishi Mushroom 17 references
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Turkey Tail Mushroom 15 references
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Cordyceps 14 references
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  11. Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
  12. Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
  13. Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
  14. Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.

See these in context on the Cordyceps monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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