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Dietary supplement

Mangosteen Extract Powder 500 mg Ingredients & Drug Interactions

by BulkSupplements.com

Mangosteen Extract Powder 500 mg label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mangosteen Extract Powder 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mangosteen Extract Powder 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mangosteen Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mangosteen Extract Powder 500 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Mangosteen Extract Powder 500 mg by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mangosteen Extract Powder 500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: mangosteen fruit extract at 500 mg per serving. Mangosteen is a tropical fruit, and this extract concentrates its compounds.

The powder also includes maltodextrin as an inactive ingredient to give it texture and help it dissolve.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Mangosteen's overall clinical evidence instead.

Moderate

Some clinical evidence supports Mangosteen for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Periodontitis — rated "Possibly Effective" (Natural Medicines).

The evidence for mangosteen extract is mixed. It's rated possibly effective for periodontitis (gum inflammation and infection).

For androgenic alopecia (male-pattern hair loss), Alzheimer disease, and atopic dermatitis (eczema), there isn't enough reliable evidence yet to say whether it works. If you're considering it for one of those conditions, talk with us about what the current research shows.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen is generally well tolerated as a food, but long-term safety of concentrated supplements hasn't been well studied. In reported trials at doses up to 560 mg daily, some people experienced mild tiredness, headache, dizziness, or nausea—though it's unclear whether mangosteen caused these.

Digestive side effects like constipation, bloating, abdominal discomfort, and diarrhea have also been reported. The safety data advises against taking this supplement during pregnancy or while breastfeeding.

There isn't enough information to know it's safe at supplement doses in either situation.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check this product if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, and others)—mangosteen may increase bleeding risk. Also check it if you take donepezil (Aricept) for Alzheimer disease, as mangosteen could raise its brain levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Mangosteen extract may be worth considering if you're looking into natural support for gum health, but you'll want to check it against any blood thinners or Alzheimer medications you take first. Pregnant or breastfeeding?

Skip this one and talk to your doctor or us about alternatives. Run your medications through our interaction checker before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mangosteen Extract Powder 500 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000WC5BBZ
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 329735
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mangosteen Extract Powder 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
1000
UPC/BARCODE
X000WC5BBZ
IngredientAmount% DV
Mangosteen Fruit Extract500 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Mangosteen Extract Powder 500 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult your physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice daily, or as directed by a physician.

General Statements

Use an accurate milligram scale. New

Storage

Store in a dry, cool place Contents are sold by weight, not volume. Settling may occur.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mangosteen Extract Powder 500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mangosteen Extract Powder 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mangosteen Extract Powder 500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.

Mangosteen Fruit Extract

Interacts with
125 drugs
500 mg per serving

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supp...

Mangosteen Fruit Extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mangosteen Extract Powder 500 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Mangosteen Extract Powder 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Mangosteen Fruit Extract 125

Individual Drug Interactions

The ingredients in Mangosteen Extract Powder 500 mg interact with 125 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mangosteen Extract Powder 500 mg interact with drugs. Each result below shows which ingredient is responsible. Mangosteen Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mangosteen Extract Powder 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mangosteen Fruit Extract2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Mangosteen Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mangosteen Extract Powder 500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Mangosteen Extract Powder 500 mg by BulkSupplements.com: Common Questions

Does Mangosteen Extract Powder 500 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Mangosteen Extract Powder 500 mg has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mangosteen Extract Powder 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is mangosteen extract, and what's it used for?
Mangosteen is a tropical fruit; this powder concentrates its active compounds. The evidence strongest for periodontitis (gum infection and inflammation)—it's rated possibly effective for that. For hair loss, Alzheimer disease, and eczema, there's not enough reliable evidence yet to say if it works.
What side effects have been reported?
At doses up to 560 mg daily, some trial participants reported mild tiredness, headache, dizziness, nausea, constipation, bloating, and abdominal discomfort. Dry throat, cough, and flu-like symptoms were also noted. It's not clear whether mangosteen caused these or something else did.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety information, so the data advises against supplement amounts during pregnancy and breastfeeding. Talk with your doctor or pharmacist about what's safe for you.
How much mangosteen is in each serving?
Each serving contains 500 mg of mangosteen fruit extract. The powder also has maltodextrin as a filler to help it mix.
Is this safe to take long-term?
Mangosteen is generally considered safe as a food, but the long-term safety of concentrated supplements hasn't been well studied. If you're thinking about taking it regularly, it's a good idea to check in with us first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mangosteen Extract Powder 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mangosteen Extract Powder 500 mg label
Go deeper

The Full Monographs Behind Mangosteen Extract Powder 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

Mangosteen Extract Powder 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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