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Dietary supplement

Maximum Strength CoQ10 600 mg Ingredients & Drug Interactions

by Protocol For Life Balance

Maximum Strength CoQ10 600 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maximum Strength CoQ10 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maximum Strength CoQ10 600 mg is a dietary supplement by Protocol For Life Balance with 3 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Coenzyme Q10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maximum Strength CoQ10 600 mg by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with Maximum Strength CoQ10 600 mg by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maximum Strength CoQ10 600 mg by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains three active ingredients. Vitamin E is an antioxidant vitamin that the body needs for nerve and immune function.

Coenzyme Q10 (CoQ10) is a compound your cells use to generate energy and protect themselves from damage. Soy lecithin is a phospholipid derived from soy that's used as an emulsifier and may support cognitive function, though evidence for that is limited.

The product also contains rice bran oil, beeswax, and the softgel capsule itself as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: mitochondrial energy production and heart health.
  • We looked for evidence on: Coenzyme Q10 deficiency, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Cardiovascular disease (CVD), Hypertension, Hyperlipidemia — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Likely Effective" for Coenzyme Q10 deficiency (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF).
  • Also on file: Vitamin E is rated "Possibly Effective" for Exercise-induced muscle damage.

Vitamin E is effective for treating vitamin E deficiency and a rare neurological condition called AVED (ataxia with vitamin E deficiency). It is possibly effective for Alzheimer's disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage, though the evidence here is less established.

CoQ10 is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraine headache, heart failure, and diabetic nerve pain. Soy lecithin's evidence isn't strong — it's been called likely ineffective for Alzheimer's and has insufficient evidence for age-related cognitive decline, anxiety, and bipolar disorder.

The evidence, ingredient by ingredient Vitamin E Lecithin Coenzyme Q10

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at dietary amounts, but high-dose long-term supplements carry risks. High doses can increase bleeding and in rare cases have been linked to hemorrhagic stroke (bleeding in the brain), particularly with synthetic forms taken for years at a time.

Coenzyme Q10 is generally well tolerated; gastrointestinal side effects like nausea, diarrhea, and heartburn occur in less than 1% of patients and are often minimized by dividing doses above 100 mg. Rare reports include headache, dizziness, insomnia, skin itching, and allergic rash.

Soy lecithin is well tolerated orally but can cause abdominal pain, diarrhea, nausea, and fullness; it may trigger allergic skin reactions in people with soy or egg allergies. Regarding pregnancy and breastfeeding: vitamin E in food and prenatal vitamins is appropriate in pregnancy, but avoid high-dose supplements without your doctor's guidance; while breastfeeding, check with your doctor before taking high-dose vitamin E.

Soy lecithin is likely safe in pregnancy and lactation. Safety data for CoQ10 in pregnancy is not reliable, and breastfeeding safety hasn't been well studied — talk with your doctor if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin E Lecithin Coenzyme Q10

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Coenzyme Q10, Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 903 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs — vitamin E and CoQ10 both carry moderate-severity bleeding risk, especially warfarin (Coumadin). If you're on chemotherapy, particularly alkylating agents or antitumor antibiotics, the antioxidant effects here may reduce drug effectiveness.

If you take medications metabolized by CYP3A4 enzymes (like certain heart, immune, and cancer drugs), vitamin E may lower their levels. Blood-pressure medications may have stronger effects when combined with CoQ10.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a three-ingredient CoQ10 supplement with notable interactions with blood thinners, certain chemotherapy drugs, and blood-pressure medications. If you take warfarin, anticoagulants, antiplatelet agents, or chemotherapy, or if you're on antihypertensive drugs, run your exact medications through the checker below or discuss this product with your own doctor or pharmacist before starting.

Generally well-tolerated gastrointestinal side effects are possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maximum Strength CoQ10 600 mg, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359131828
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2014
DSLD ID 31433
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maximum Strength CoQ10 600 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
707359131828
IngredientAmount% DV
Calories10 {Calories}--
Total Carbohydrates1 Gram(s)1%
Vitamin E30 IU100%
Soy Lecithin50 mg--
Calories from Fat5 {Calories}--
Total Fat0.5 Gram(s)1%
Coenzyme Q10600 mg--

Other ingredients: Rice Bran Oil, Softgel Capsule, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Protocol For Life Balance(R) CoQ10 is Pharmaceutical Grade, natural, all-trans form of CoQ10 produced by fermentation.

Suggested/Recommended/Usage/Directions

SUGGESTED USAGE: As a dietary supplement, take 1 softgel daily with a fat-containing meal, or as directed by your healthcare practitioner.

Formula

This product has more CoQ10 (600 mg per softgel) than our regular strength product (60 mg per softgel).

With Lecithin & Vitamin E

General

CODE P3182 V4

General Statements

HOW IT WORKS: Coenzyme Q10, also called ubiquinone, is present in almost all cells, where it is necessary for mitochondrial energy production. The body's highest concentrations of Coenzyme Q10 (CoQ10) are found in the heart, where constant chemical energy availability is imperative. In addition to its critical role in energy production, CoQ10 also functions as a powerful fat soluble free radical scavenger for vascular structures, as well as for other tissues including the brain and nerves.

For more information on this product go to www.protocolforlife.com/P3182.

Supports Healthy Heart Muscle

Please Recycle.

Precautions

CAUTIONS/INTERACTIONS: Coenzyme Q10 may interact with anticoagulant and antihypertensive medications, as well as chemotherapy agents. Statin medications have been shown to decrease CoQ10 levels in the body and CoQ10 supplementation may be useful when taking these drugs. Consult your healthcare professional if you are taking any of these medications.

Not manufactured with wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

This bottle contains an Ageless(R) oxygen absorbing packet to ensure freshness. Do not eat Packet.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

GMP

Formulation

PEG-Free.

Not manufactured with wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maximum Strength CoQ10 600 mg by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maximum Strength CoQ10 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maximum Strength CoQ10 600 mg by Protocol For Life Balance

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
30 IU per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Soy Lecithin

No known
interactions
50 mg per serving

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...

Soy Lecithin monograph & interactions

Coenzyme Q10

Interacts with
198 drugs
600 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Other (inactive) ingredients: Rice Bran Oil, Softgel Capsule, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maximum Strength CoQ10 600 mg by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against Maximum Strength CoQ10 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
902Drugs
763 Moderate 139 Minor

Ingredients driving the most interactions

Vitamin E 764
Coenzyme Q10 198

Individual Drug Interactions

The ingredients in Maximum Strength CoQ10 600 mg interact with 902 drugs. Click any drug to see the details.

2 of the 3 ingredients in Maximum Strength CoQ10 600 mg interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Coenzyme Q10

Each ingredient & the kinds of drugs it affects

For each ingredient in Maximum Strength CoQ10 600 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maximum Strength CoQ10 600 mg, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Web Address
www.protocolforlife.com
Pharmacist Counseling Corner

Maximum Strength CoQ10 600 mg by Protocol For Life Balance: Common Questions

Does Maximum Strength CoQ10 600 mg by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, Maximum Strength CoQ10 600 mg has a known interaction with 902 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maximum Strength CoQ10 600 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
Not without checking first. Both the vitamin E and CoQ10 in this product interact with blood thinners and can increase bleeding risk. CoQ10 may also make warfarin less effective — there are documented cases of this. Talk with your doctor or pharmacist before starting; they may need to monitor you more closely or adjust your dose.
Will this help with my migraines?
CoQ10 is possibly effective for migraine headache, based on available evidence. Vitamin E and soy lecithin don't have established effectiveness for migraines. If you're interested in trying this for that reason, discuss it with your doctor, especially if you're on other medications.
Is this safe during pregnancy?
Vitamin E at food and prenatal vitamin amounts is fine, but avoid high-dose supplements unless your doctor directs it. Soy lecithin is likely safe, but CoQ10 doesn't have enough reliable safety data — talk with your doctor before taking it during pregnancy to get personalized advice.
What's CoQ10 actually for in the body?
CoQ10 is a compound your cells use to make energy and protect themselves from oxidative damage. Your body makes some on its own, but production can decline with age or certain medications. This product provides a 600 mg dose per serving.
Can I take this while breastfeeding?
Soy lecithin is likely safe while breastfeeding. Vitamin E in normal dietary amounts is fine, but check with your doctor before taking high-dose vitamin E supplements. Safety data for CoQ10 while breastfeeding hasn't been well studied, so it's worth discussing with your healthcare provider.
What side effects should I expect?
Gastrointestinal upset — nausea, diarrhea, heartburn, stomach discomfort, loss of appetite — is the most common, occurring in less than 1% of people and usually mild. Soy lecithin can also cause abdominal pain and fullness. Rare reports include headache, dizziness, insomnia, and skin reactions. Taking doses above 100 mg split throughout the day may help.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maximum Strength CoQ10 600 mg label
Go deeper

The Full Monographs Behind Maximum Strength CoQ10 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Lecithin

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...

Read the full Lecithin monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph →
Sources

Sources & How We Checked

Maximum Strength CoQ10 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 113 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  24. Schrogie JJ. Coagulopathy and fat-soluble vitamins (letter). JAMA 1975;232:19. DOI
  25. Celestini A, Pulcinelli FM, Pignatelli P, et al. Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets. Haematologica 2002;87:420-6.
  26. Stampfer MJ, Jakubowski JA, Faigel D, et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. Am J Clin Nutr 1988;47:700-6. PubMed
  27. Jandak J, Steiner M, Richardson PD. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood 1989;73:141-9. DOI
  28. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996;94:2434-40. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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