Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Melatonin-Free Sleep Tart Cherry Peach Flavor Ingredients & Drug Interactions

by vitafusion

Melatonin-Free Sleep Tart Cherry Peach Flavor label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Melatonin-Free Sleep Tart Cherry Peach Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Melatonin-Free Sleep Tart Cherry Peach Flavor is a dietary supplement by vitafusion with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 997 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chamomile Flower Extract, Passion Flower extract, Lemon Balm Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion

Ask about any prescription or over-the-counter medication and we check it for interactions with Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This gummy contains 4 active ingredients chosen for sleep support. Lemon balm leaf extract and passion flower extract are both herbal extracts traditionally used to help with relaxation and sleep.

Chamomile flower extract is another calming botanical, though we don't have detailed data on file for it. Lutemax 2020 is a specialized extract — we don't have interaction information for it either.

The rest of the gummy is made up of common inactive ingredients like glucose syrup, gelatin, pectin, and natural flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports sleep quality.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Sleep disturbance, Restlessness, Nervousness.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety, Insomnia.
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

Lemon balm is possibly effective for stress and has been studied for cold sores and depression, though the strength of that evidence is modest. Passion flower is possibly effective for insomnia and pre-procedural anxiety — that's where the strongest case exists for this product's sleep-support purpose.

The evidence for both ingredients on other uses (like passion flower for alcohol withdrawal or benzodiazepine withdrawal) is currently insufficient to rate. We don't have effectiveness data on file for chamomile or Lutemax 2020.

The evidence, ingredient by ingredient Lemon Balm Passion Flower German Chamomile

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both lemon balm and passion flower are generally well tolerated short-term in healthy adults, though neither has strong data on long-term safety. The main reported side effect is drowsiness — which is expected in a sleep product, but worth noting if you're taking other sedating drugs.

A small number of people have reported dizziness or mild sedation with lemon balm, though those didn't happen more often than with placebo. Rare case reports exist for both ingredients involving serious heart rhythm changes, though these occurred with specific combination products and high doses, making it unclear whether the herbs alone were responsible.

Lemon balm is best avoided during pregnancy unless your doctor advises otherwise, and caution is warranted while breastfeeding due to limited safety data. Passion flower should be avoided in pregnancy because of insufficient safety data and possible effects on the uterus, and it's also best avoided while breastfeeding.

Side effects, ingredient by ingredient Lemon Balm Passion Flower German Chamomile

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lemon Balm, Passion Flower, German Chamomile.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 998 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before using if you take CNS depressants (sedatives, sleep aids, some pain medications, or antidepressants) — lemon balm and passion flower can add to their effects. If you take thyroid hormone replacement therapy, lemon balm may interfere.

Also verify any medications that rely on CYP3A4 processing or OATP transport proteins with your pharmacist, since passion flower may affect how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with sleep or relaxation if you're looking for herbal support, particularly if passion flower's calming effects appeal to you. If you take any sedating medications, thyroid hormone replacement, or drugs that depend on certain liver enzymes, talk to your pharmacist or doctor first — the ingredient interactions are real and could affect how your medications work.

Pregnant or breastfeeding? Check with your doctor before using.

Run your full medication list through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Melatonin-Free Sleep Tart Cherry Peach Flavor, straight from the product label.

Brand vitafusion
Barcode (UPC) 027917002163
Net contents 40 Gummy(ies)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 331687
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
20
UPC/BARCODE
027917002163
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Lemon Balm Leaf Extract8 mg--
Passion Flower extract8.5 mg--
Chamomile Flower Extract8.5 mg--
Lutemax 2020200 mg--

Other ingredients: Glucose Syrup, Sugar, Water, Gelatin, Citric Acid, Fumaric Acid, Malic Acid, Natural Flavors, Pectin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Gummy Supplements Supports Sleep Quality Adult Sleep Support

To ensure quality and potency through expiration, this dietary Supplement is manufactured with higher active ingredient levels than the indicated Amount Per Serving.

If you have a medical condition, are on medication, are pregnant or nursing or have questions regarding your nutritional needs, consult a qualified healthcare professional before using this product.

Colors will darken over time. This does not alter the potency of the product.

vitafusion Melatonin-Free Sleep Melatonin-Free Sleep is a delicious way to help support sleep quality.

NO Artificial Flavors or Sweeteners NO Gluten NO High Fructose Corn Syrup NO Dairy NO Synthetic FD&C Dyes

Formula

Melatonin-Free Sleep With 200 mg of Lutemax 2020 per serving

Formulated for adults with 200mg of Lutemax 2020 per serving, these tart cherry peach flavored gummies are a great addition to any sleep routine.

General Statements

America's #1 Gummy Vitamin Brand

Questions, Comments? Call 1-888-334-5389 M-F9AM-5PM ET www.witafusion.com

Discard seal, empty & replace cap Plastic bottle Bottle not recyclable unless label removed Plastic label how2recycle.info

GROWING COMMUNITIES with Fruitful Planting We believe in holistic wellness and realize it's more than just taking vitamins. That's why we support the Fruit Tree Planting Foundation and together have planted more than 200,000 fruit trees in underserved communities. Join our mission vitafusion.com

Suggested/Recommended/Usage/Directions

Suggested use: Adults take two (2) gummies prior to sleep event. Chew thoroughly.

Precautions

Processed in a facility with products that contain egg, fish, shellfish, soy and tree nuts.

Keep out of the reach of children

Do not drive or operate machinery after taking.

Take only as directed. Do not exceed suggested dosage.

An individual's need for this product may be met through a varied and well balanced diet. Do not use if the inner seal is broken or missing.

Brand IP Statement(s)

Lutemax 2020 is a trademark of OmniActive Health Technologies Ltd.

Storage

This product may settle during shipping. Store in a cool, dry place,

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent.

Seals/Symbols

Certified renewable energy Green-e Made with 100% certified renewable electricity.

Made in the USA With US & International Ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Melatonin-Free Sleep Tart Cherry Peach Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lemon Balm Leaf Extract

Interacts with
264 drugs
8 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm Leaf Extract monograph & interactions

Passion Flower extract

Interacts with
836 drugs
8.5 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passion Flower extract monograph & interactions

Chamomile Flower Extract

Interacts with
960 drugs
8.5 mg per serving Form: Chamomilla recutita Flower Extract

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible b...

Chamomile Flower Extract monograph & interactions

Lutemax 2020

200 mg per serving Form: Lutein, Zeaxanthin

Other (inactive) ingredients: Glucose Syrup, Sugar, Water, Gelatin, Citric Acid, Fumaric Acid, Malic Acid, Natural Flavors, Pectin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion Drug Interactions

Want to check YOUR meds against Melatonin-Free Sleep Tart Cherry Peach Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
997Drugs
938 Moderate 59 Minor

Ingredients driving the most interactions

Chamomile Flower Extract 960
Passion Flower extract 836
Lemon Balm Leaf Extract 264

Individual Drug Interactions

The ingredients in Melatonin-Free Sleep Tart Cherry Peach Flavor interact with 997 drugs. Click any drug to see the details.

3 of the 4 ingredients in Melatonin-Free Sleep Tart Cherry Peach Flavor interact with drugs. Each result below shows which ingredient is responsible. Chamomile Flower Extract Passion Flower extract Lemon Balm Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Melatonin-Free Sleep Tart Cherry Peach Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chamomile Flower Extract9 drug types · 960 drugs

Cns Depressants

Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.

Likelihood Possible Evidence D
Estrogens

Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.

Likelihood Possible Evidence D
Warfarin (Coumadin)

German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.

Likelihood Possible Evidence D
Chamomile Flower Extract full monograph & interactions

Passion Flower extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passion Flower extract full monograph & interactions

Lemon Balm Leaf Extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Melatonin-Free Sleep Tart Cherry Peach Flavor, from the product label.

vitafusion

See all vitafusion products
Name
Church & Dwight Co., Inc.
City
Ewing
State
NJ
ZipCode
08628
Phone Number
1-888-334-5389
Web Address
www.vitafusion.com
Pharmacist Counseling Corner

Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion: Common Questions

Does Melatonin-Free Sleep Tart Cherry Peach Flavor by vitafusion interact with any medications?
Yes. Based on its ingredients, Melatonin-Free Sleep Tart Cherry Peach Flavor has a known interaction with 997 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Melatonin-Free Sleep Tart Cherry Peach Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Drowsiness is an expected effect since both lemon balm and passion flower are sedating ingredients meant to help you sleep or relax. In trials, reported drowsiness with lemon balm didn't happen more often than placebo, but it can occur, especially at higher doses. If you're sensitive to sedating herbs, start with a lower dose and see how you feel.
Is it safe during pregnancy?
No. Lemon balm is best avoided in pregnancy unless your doctor advises otherwise, and passion flower should be avoided entirely during pregnancy due to insufficient safety data and possible effects on the uterus. Talk to your doctor if you're pregnant and looking for sleep support.
Can I use this while breastfeeding?
Both lemon balm and passion flower have limited safety information for breastfeeding, so caution is warranted with lemon balm and it's best avoided with passion flower. Talk to your doctor or pharmacist for personalized advice before using while breastfeeding.
What is lemon balm used for in this product?
Lemon balm is included for its calming properties — it's possibly effective for stress and may help with sleep or relaxation. It also has some evidence for cold sores and depression, though that's not the main reason it's in a sleep gummy.
What does passion flower do?
Passion flower is a sedative herb that's possibly effective for insomnia and anxiety, which fits this product's sleep-support purpose. It's included to help calm your mind and prepare your body for rest.
I take thyroid medication — is this safe for me?
Possibly not without checking first. Lemon balm may theoretically interfere with how your thyroid hormone replacement works, so talk to your pharmacist or doctor before using this product alongside thyroid medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Melatonin-Free Sleep Tart Cherry Peach Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Melatonin-Free Sleep Tart Cherry Peach Flavor label
Go deeper

The Full Monographs Behind Melatonin-Free Sleep Tart Cherry Peach Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

German Chamomile

Interacts with 960 drugs

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...

Read the full German Chamomile monograph →
Sources

Sources & How We Checked

Melatonin-Free Sleep Tart Cherry Peach Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 46 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
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  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

German Chamomile 15 references
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  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
  4. van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
  5. van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
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  14. Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 2015;38(4):32 PubMed
  15. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T

See these in context on the German Chamomile monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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