Metha-Quad Extreme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Metha-Quad Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Metha-Quad Extreme is a dietary supplement by Blackstone Labs with 4 active ingredients. Its ingredients are commonly taken for muscle building and athletic performance, boosting testosterone or androgen levels, supporting libido.Based on those ingredients, 13 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androsterone, 1-Androstene-3Beta-Ol,17-One, Androsta-3,5-Diene-7,17-Dione. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Metha-Quad Extreme by Blackstone Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Metha-Quad Extreme by Blackstone Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Metha-Quad Extreme by Blackstone Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 4 active ingredients, all androgenic compounds or prohormones: androsterone, 1-androstene-3beta-ol,17-one, 4-androstene-3beta-ol,17-one, and androsta-3,5-diene-7,17-dione (arimistane). These are hormone-altering compounds designed to affect testosterone and estrogen pathways in the body.
The product also contains several inactive ingredients—microcrystalline cellulose, phosphatidylcholine, hydroxypropyl-beta-cyclodextrin, phytosterol, stearic acid, magnesium stearate, starch, titanium dioxide, silica, and food colorants (FD&C #40 and Yellow #6)—which serve as binders, fillers, and coating materials.
Does it work?
Insufficient evidence
The evidence supporting these ingredients is not established in our data. All four active ingredients carry ratings of insufficient reliable evidence for their stated purposes—athletic performance, sexual function, muscle strength, obesity, and erectile dysfunction among them.
This means trials have not yet demonstrated clear benefit for these uses, or the available research is too limited to make a confident assessment.
How safe is it?
Well-documented data
These ingredients carry significant safety concerns. Androsterone is a controlled anabolic-androgenic steroid illegal to sell as a dietary supplement in the U.S., and it is possibly unsafe orally with concern for serious side effects including heart disease and liver injury.
The three prohormones (1-androstene-3beta-ol,17-one, 4-androstene-3beta-ol,17-one, and arimistane) are hormone-altering compounds with limited safety testing. Trial participants taking 1-androstene-3beta-ol,17-one showed significant changes in cholesterol (LDL up ~29 mg/dL, HDL down ~19 mg/dL) and kidney function (creatinine elevation and a drop in GFR below 89 mL/min/1.72m², suggesting early kidney impairment) over 4 weeks, plus abnormal liver enzymes and problems with lipid metabolism.
None of these ingredients should be used during pregnancy or while breastfeeding due to risk of harm to the baby from hormone exposure.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications with your doctor or pharmacist if you take testosterone or any other androgenic drugs (Moderate severity risk), or aromatase inhibitors used for estrogen control (Moderate severity risk). These combinations may increase the risk of mood disturbances, cardiovascular problems, kidney or liver injury, and low-estrogen side effects.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product contains androgenic hormones and prohormones with insufficient evidence of benefit and documented risks to the heart, liver, kidneys, and cholesterol profile. It is not appropriate for use during pregnancy or breastfeeding, and androsterone itself is illegal to sell as a supplement in the U.S.
If you're considering this product, talk with your own doctor or pharmacist first—especially if you take testosterone, other androgens, or aromatase inhibitors.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Metha-Quad Extreme, straight from the product label.
| Brand | Blackstone Labs |
|---|---|
| Net contents | 30 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Sep 21, 2018 |
| DSLD ID | 180666 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Metha-Quad Extreme by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Androsterone | 150 mg | -- |
| 1-Androstene-3Beta-Ol,17-One | 50 mg | -- |
| 4-Androstene-3Beta-Ol,17-One | 50 mg | -- |
| Androsta-3,5-Diene-7,17-Dione | 50 mg | -- |
Other ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C #40, FD&C Yellow #6
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
4-in-1 pro-anabolic Ultimate mass stack
FDA Statement of Identity
Dietary Supplement
Precautions
Allergen warning: Manufactured on shared equipment that also processes eggs, wheat, & soy (lecithin).
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Metha-Quad Extreme by Blackstone Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Metha-Quad Extreme by Blackstone Labs
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Androsterone
Interacts with9 drugs
Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are...
Androsterone monograph & interactions1-Androstene-3Beta-Ol,17-One
Interacts with8 drugs
1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...
1-Androstene-3Beta-Ol,17-One monograph & interactions4-Androstene-3Beta-Ol,17-One
Interacts with8 drugs
1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...
4-Androstene-3Beta-Ol,17-One monograph & interactionsAndrosta-3,5-Diene-7,17-Dione
Interacts with4 drugs
Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone,...
Androsta-3,5-Diene-7,17-Dione monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C #40, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.
Metha-Quad Extreme by Blackstone Labs Drug Interactions
HelloPharmacist Interaction Report
Metha-Quad Extreme by Blackstone Labs contains four androgenic and hormone-altering ingredients—androsterone, 1-androstene-3beta-ol,17-one, 4-androstene-3beta-ol,17-one, and androsta-3,5-diene-7,17-dione—that carry documented interactions with testosterone and aromatase inhibitors (drugs that lower estrogen).
The most serious finding is that three of these ingredients may interact with testosterone at Moderate severity, raising the risk of mood changes and heart, kidney, or liver problems if combined.
Read the full breakdown — every affected drug type, severity by severity
Androsterone carries a Minor interaction with other androgenic drugs, again through shared receptor activity. Androsta-3,5-diene-7,17-dione (arimistane) may interact with aromatase inhibitor medications at Moderate severity, potentially increasing liver toxicity risk and side effects from low estrogen.
Altogether, these interactions span 13 individual medications.
Before you take this product, run your exact medications—especially any testosterone replacement, other androgens, or aromatase inhibitors—through the interaction checker on this page, or talk with your own doctor or pharmacist. We hold no interaction data for the inactive ingredients.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Metha-Quad Extreme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Metha-Quad Extreme interact with 13 drugs. Click any drug to see the details.
3 of the 4 ingredients in Metha-Quad Extreme interact with drugs. Each result below shows which ingredient is responsible. Androsterone 1-Androstene-3Beta-Ol,17-One Androsta-3,5-Diene-7,17-Dione
TiboloneLivial
How Tibolone interacts with Metha-Quad Extreme — through 1 ingredient. Tap an ingredient for the detail:
AndrosteroneAndrogens Minor
Interaction Summary
Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action.
Read the full Androsterone + Tibolone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Metha-Quad Extreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Androsterone
Androgens
Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action. Both androsterone and testosterone bind to androgen receptors in various tissues throughout the body, leading to similar physiological effects related to the development and maintenance of male secondary sexual characteristics. When taken together, these compounds can potentially amplify these effects, leading to an increased risk of androgenic side effects, such as acne, hair loss, and changes in libido. Additionally, combining androsterone with testosterone or other androgenic drugs may also affect hormone levels and balance in the body, potentially leading to hormonal imbalances or disruptions in the endocrine system.
1-Androstene-3Beta-Ol,17-One
Testosterone
Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
1-Androsterone is converted to 1-testosterone and other androgens upon ingestion.
Androsta-3,5-Diene-7,17-Dione
Aromatase Inhibitors
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.
Brand information
Manufacturer and brand details for Metha-Quad Extreme, from the product label.
Metha-Quad Extreme by Blackstone Labs: Common Questions
Does Metha-Quad Extreme by Blackstone Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is androsterone in this product legal?
Can I take this while pregnant or breastfeeding?
What are the most common side effects?
Do these ingredients actually work for athletic performance or muscle?
Can I take this with testosterone or other hormone medications?
Why does this product have so many inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Metha-Quad Extreme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Metha-Quad Extreme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Androsterone
Interacts with 9 drugsAndrosterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements und...
Read the full Androsterone monograph → Herb & supplement monograph1-androsterone
Interacts with 8 drugs1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It...
Read the full 1-androsterone monograph → Herb & supplement monographArimistane
Interacts with 4 drugsArimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohor...
Read the full Arimistane monograph →Sources & How We Checked
Metha-Quad Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Androsterone 1 reference
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
1-androsterone 2 references
- Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
- Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.
Arimistane 1 reference
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC