Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Metha-Quad Extreme Ingredients & Drug Interactions

by Blackstone Labs

Metha-Quad Extreme label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Metha-Quad Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Metha-Quad Extreme is a dietary supplement by Blackstone Labs with 4 active ingredients. Its ingredients are commonly taken for muscle building and athletic performance, boosting testosterone or androgen levels, supporting libido.Based on those ingredients, 13 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androsterone, 1-Androstene-3Beta-Ol,17-One, Androsta-3,5-Diene-7,17-Dione. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Metha-Quad Extreme by Blackstone Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Metha-Quad Extreme by Blackstone Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Metha-Quad Extreme by Blackstone Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients, all androgenic compounds or prohormones: androsterone, 1-androstene-3beta-ol,17-one, 4-androstene-3beta-ol,17-one, and androsta-3,5-diene-7,17-dione (arimistane). These are hormone-altering compounds designed to affect testosterone and estrogen pathways in the body.

The product also contains several inactive ingredients—microcrystalline cellulose, phosphatidylcholine, hydroxypropyl-beta-cyclodextrin, phytosterol, stearic acid, magnesium stearate, starch, titanium dioxide, silica, and food colorants (FD&C #40 and Yellow #6)—which serve as binders, fillers, and coating materials.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Muscle building and athletic performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Body composition, Anabolic support, Strength gains.
  • The closest evidence on file: 1-androsterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Androsterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Exercise-induced muscle damage.
  • Also on file: Arimistane is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.

The evidence supporting these ingredients is not established in our data. All four active ingredients carry ratings of insufficient reliable evidence for their stated purposes—athletic performance, sexual function, muscle strength, obesity, and erectile dysfunction among them.

This means trials have not yet demonstrated clear benefit for these uses, or the available research is too limited to make a confident assessment.

The evidence, ingredient by ingredient Androsterone 1-androsterone Arimistane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These ingredients carry significant safety concerns. Androsterone is a controlled anabolic-androgenic steroid illegal to sell as a dietary supplement in the U.S., and it is possibly unsafe orally with concern for serious side effects including heart disease and liver injury.

The three prohormones (1-androstene-3beta-ol,17-one, 4-androstene-3beta-ol,17-one, and arimistane) are hormone-altering compounds with limited safety testing. Trial participants taking 1-androstene-3beta-ol,17-one showed significant changes in cholesterol (LDL up ~29 mg/dL, HDL down ~19 mg/dL) and kidney function (creatinine elevation and a drop in GFR below 89 mL/min/1.72m², suggesting early kidney impairment) over 4 weeks, plus abnormal liver enzymes and problems with lipid metabolism.

None of these ingredients should be used during pregnancy or while breastfeeding due to risk of harm to the baby from hormone exposure.

Side effects, ingredient by ingredient Androsterone 1-androsterone Arimistane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — 1-androsterone, Androsterone, Arimistane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 13 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications with your doctor or pharmacist if you take testosterone or any other androgenic drugs (Moderate severity risk), or aromatase inhibitors used for estrogen control (Moderate severity risk). These combinations may increase the risk of mood disturbances, cardiovascular problems, kidney or liver injury, and low-estrogen side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains androgenic hormones and prohormones with insufficient evidence of benefit and documented risks to the heart, liver, kidneys, and cholesterol profile. It is not appropriate for use during pregnancy or breastfeeding, and androsterone itself is illegal to sell as a supplement in the U.S.

If you're considering this product, talk with your own doctor or pharmacist first—especially if you take testosterone, other androgens, or aromatase inhibitors.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Metha-Quad Extreme, straight from the product label.

Brand Blackstone Labs
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 180666
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Metha-Quad Extreme by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
IngredientAmount% DV
Androsterone150 mg--
1-Androstene-3Beta-Ol,17-One50 mg--
4-Androstene-3Beta-Ol,17-One50 mg--
Androsta-3,5-Diene-7,17-Dione50 mg--

Other ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C #40, FD&C Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

4-in-1 pro-anabolic Ultimate mass stack

FDA Statement of Identity

Dietary Supplement

Precautions

Allergen warning: Manufactured on shared equipment that also processes eggs, wheat, & soy (lecithin).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Metha-Quad Extreme by Blackstone Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Metha-Quad Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Metha-Quad Extreme by Blackstone Labs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Androsterone

Interacts with
9 drugs
150 mg per serving

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are...

Androsterone monograph & interactions

1-Androstene-3Beta-Ol,17-One

Interacts with
8 drugs
50 mg per serving

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...

1-Androstene-3Beta-Ol,17-One monograph & interactions

4-Androstene-3Beta-Ol,17-One

Interacts with
8 drugs
50 mg per serving

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...

4-Androstene-3Beta-Ol,17-One monograph & interactions

Androsta-3,5-Diene-7,17-Dione

Interacts with
4 drugs
50 mg per serving

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone,...

Androsta-3,5-Diene-7,17-Dione monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C #40, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Metha-Quad Extreme by Blackstone Labs Drug Interactions

Want to check YOUR meds against Metha-Quad Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
13Drugs
12 Moderate 1 Minor

Ingredients driving the most interactions

Androsterone 9
1-Androstene-3Beta-Ol,17-One 8
Androsta-3,5-Diene-7,17-Dione 4

Individual Drug Interactions

The ingredients in Metha-Quad Extreme interact with 13 drugs. Click any drug to see the details.

3 of the 4 ingredients in Metha-Quad Extreme interact with drugs. Each result below shows which ingredient is responsible. Androsterone 1-Androstene-3Beta-Ol,17-One Androsta-3,5-Diene-7,17-Dione

Each ingredient & the kinds of drugs it affects

For each ingredient in Metha-Quad Extreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Androsterone1 drug type · 9 drugs

Androgens

Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action. Both androsterone and testosterone bind to androgen receptors in various tissues throughout the body, leading to similar physiological effects related to the development and maintenance of male secondary sexual characteristics. When taken together, these compounds can potentially amplify these effects, leading to an increased risk of androgenic side effects, such as acne, hair loss, and changes in libido. Additionally, combining androsterone with testosterone or other androgenic drugs may also affect hormone levels and balance in the body, potentially leading to hormonal imbalances or disruptions in the endocrine system.

Likelihood Possible Evidence C
Androsterone full monograph & interactions

1-Androstene-3Beta-Ol,17-One1 drug type · 8 drugs

Testosterone

Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
1-Androsterone is converted to 1-testosterone and other androgens upon ingestion.

Likelihood Possible Evidence D
1-Androstene-3Beta-Ol,17-One full monograph & interactions

Androsta-3,5-Diene-7,17-Dione1 drug type · 4 drugs

Aromatase Inhibitors

It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.

Likelihood Probable Evidence C
Androsta-3,5-Diene-7,17-Dione full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Metha-Quad Extreme, from the product label.

Blackstone Labs

See all Blackstone Labs products
Name
Blackstone Labs
Pharmacist Counseling Corner

Metha-Quad Extreme by Blackstone Labs: Common Questions

Does Metha-Quad Extreme by Blackstone Labs interact with any medications?
Yes. Based on its ingredients, Metha-Quad Extreme has a known interaction with 13 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Metha-Quad Extreme contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is androsterone in this product legal?
No. Androsterone is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S. Its inclusion raises serious legal and safety questions about this product.
Can I take this while pregnant or breastfeeding?
No. All four active ingredients are hormone-altering and carry a rating of Possibly Unsafe during pregnancy and lactation. Hormone exposure can harm a developing baby and affect an infant through breast milk. Do not use this product if you are pregnant or breastfeeding.
What are the most common side effects?
The ingredients in this product can cause abnormal cholesterol levels (higher LDL and lower HDL), liver enzyme elevation, kidney function problems (elevated creatinine and reduced GFR), and changes in lipid metabolism. There is also concern for serious side effects including heart disease and liver injury with androsterone. Many of these effects were observed in trial participants over just 4 weeks.
Do these ingredients actually work for athletic performance or muscle?
The evidence is not established. All active ingredients carry a rating of insufficient reliable evidence for athletic performance, muscle strength, sexual function, or obesity. This means trials have not yet shown clear benefit.
Can I take this with testosterone or other hormone medications?
Not without talking to your doctor first. This product interacts with testosterone and other androgenic drugs at Moderate severity, raising the risk of mood changes and heart, kidney, or liver problems. Check with your own doctor or pharmacist before combining them.
Why does this product have so many inactive ingredients?
The inactive ingredients—microcrystalline cellulose, starch, magnesium stearate, silica, and food colorants—serve as binders, fillers, and coating materials to form and stabilize the tablet. They are not active in the body but help deliver the active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Metha-Quad Extreme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Metha-Quad Extreme label
Go deeper

The Full Monographs Behind Metha-Quad Extreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Androsterone

Interacts with 9 drugs

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements und...

Read the full Androsterone monograph → Herb & supplement monograph

1-androsterone

Interacts with 8 drugs

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It...

Read the full 1-androsterone monograph → Herb & supplement monograph

Arimistane

Interacts with 4 drugs

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohor...

Read the full Arimistane monograph →
Sources

Sources & How We Checked

Metha-Quad Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Androsterone 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Androsterone monograph →

1-androsterone 2 references
  1. Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
  2. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.

See these in context on the 1-androsterone monograph →

Arimistane 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Arimistane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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