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Dietary supplement

Tri Andro Ingredients & Drug Interactions

by Primeval Labs

Tri Andro label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tri Andro against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tri Andro is a dietary supplement by Primeval Labs with 3 active ingredients. Its ingredients are commonly taken for muscle building, increasing strength, athletic performance.Based on those ingredients, 8 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 1-Androsterone, 4-Androsterone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tri Andro by Primeval Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Tri Andro by Primeval Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tri Andro by Primeval Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Tri Andro contains 3 active ingredients, all prohormones — compounds your body may convert into testosterone and related hormones. You get 1-androsterone, 4-androsterone, and epiandrosterone in each dose.

The product also includes several inactive ingredients: soy lecithin, microcrystalline cellulose, dicalcium phosphate, cyclodextrin, polyvinylpyrrolidone, silica, and magnesium stearate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: mass aggression strength muscle building.
  • We looked for evidence on: Athletic performance, Muscle strength, Exercise-induced muscle damage, Lean body mass, Power output, Muscular endurance.
  • The closest evidence on file: 1-androsterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Epiandrosterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Exercise-induced muscle damage.

Here's the honest take: the evidence we hold doesn't support any of these ingredients for their intended uses. 1-Androsterone has insufficient reliable evidence for athletic performance.

4-Androsterone has no effectiveness data on file. Epiandrosterone shows insufficient reliable evidence for athletic performance, muscle strength, erectile dysfunction, sexual arousal, and obesity.

In other words, the science behind whether these prohormones actually work the way the label suggests just isn't there.

The evidence, ingredient by ingredient 1-androsterone 4-androsterone Epiandrosterone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This is where you need to pay close attention. 1-Androsterone and 4-androsterone are real hormonal compounds with genuine health risks and very limited safety testing.

The most common adverse effects reported with 1-androsterone are abnormal cholesterol levels (LDL up around 29 mg/dL, HDL down around 19 mg/dL), liver enzyme elevation, and kidney problems — including a drop in kidney filtration rate below normal after just 4 weeks. 4-Androsterone carries theoretical risk of stroke, kidney failure, and liver injury based on its anabolic steroid-like properties, though we don't have detailed adverse effect data.

Epiandrosterone has limited safety data and real potential for hormone-related side effects. Pregnancy and breastfeeding: the safety data advises against using any of these ingredients during pregnancy or while breastfeeding.

The hormonal effects on a developing baby or nursing infant are either unknown or potentially harmful.

Side effects, ingredient by ingredient 1-androsterone 4-androsterone Epiandrosterone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — 1-androsterone, 4-androsterone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 8 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tri Andro, double-check any testosterone products or hormone therapies with your doctor or pharmacist — a Moderate interaction is documented. The product's prohormone ingredients may also affect how your liver and kidneys handle other medications, so clear it with your healthcare provider if you're on any prescription drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Tri Andro is a prohormone product — it's not a supplement in the traditional sense, and it carries the same serious health and safety questions that anabolic hormones do. If you're considering it for athletic performance or muscle strength, keep in mind the evidence doesn't show it works.

If you take testosterone or have liver, kidney, or heart concerns, this product is risky territory. Talk with your doctor or pharmacist before you start, especially if you're on any medications or have existing health conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tri Andro, straight from the product label.

Brand Primeval Labs
Net contents 90 Tab(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 172547
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tri Andro by Primeval Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
IngredientAmount% DV
1-Androsterone75 mg--
4-Androsterone75 mg--
Epiandrosterone150 mg--

Other ingredients: Phospholipids from non-GMO Soy Lecithin, Microcrystalline Cellulose, Dicalcium Phosphate, Hydroxy Propyl Beta Cyclodextrin, Polyvinylpyrrolidone, Silica, Colloidal Anhydrous, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Mass Aggression Strength

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for Tri Andro: As a dietary supplement, take 1 tablet 3 times daily spaced evenly throughout the day. Do not use Tri Andro for longer than 8 weeks continuously. Take at least 8 weeks off between cycles.

Precautions

Do not use Tri Andro for longer than 8 weeks continuously. Warnings: Read entire label and obtain clearance from a licensed healthcare practitioner before use. This product is to be used by healthy adults only.

Do not use if you have or could develop any medical condition or are taking any prescription drugs. Do not use if you are pregnant, nursing, or may become pregnant.

Do not use more than the recommended dosage. Discontinue use and consent a physician if any adverse reactions occur.

As with all supplements, keep out of reach of children and animals.

Storage

Keep lid tightly closed and in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tri Andro by Primeval Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tri Andro label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tri Andro by Primeval Labs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

1-Androsterone

Interacts with
8 drugs
75 mg per serving

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...

1-Androsterone monograph & interactions

4-Androsterone

Interacts with
8 drugs
75 mg per serving

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human...

4-Androsterone monograph & interactions

Epiandrosterone

No known
interactions
150 mg per serving

Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic perfor...

Epiandrosterone monograph & interactions

Other (inactive) ingredients: Phospholipids from non-GMO Soy Lecithin, Microcrystalline Cellulose, Dicalcium Phosphate, Hydroxy Propyl Beta Cyclodextrin, Polyvinylpyrrolidone, Silica, Colloidal Anhydrous, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tri Andro by Primeval Labs Drug Interactions

Want to check YOUR meds against Tri Andro?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
8Drugs
8 Moderate

Ingredients driving the most interactions

1-Androsterone 8
4-Androsterone 8

Individual Drug Interactions

The ingredients in Tri Andro interact with 8 drugs. Click any drug to see the details.

2 of the 3 ingredients in Tri Andro interact with drugs. Each result below shows which ingredient is responsible. 1-Androsterone 4-Androsterone

Each ingredient & the kinds of drugs it affects

For each ingredient in Tri Andro with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

1-Androsterone1 drug type · 8 drugs

Testosterone

Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
1-Androsterone is converted to 1-testosterone and other androgens upon ingestion.

Likelihood Possible Evidence D
1-Androsterone full monograph & interactions

4-Androsterone1 drug type · 8 drugs

Testosterone

4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion. Theoretically, taking 4-androsterone with testosterone may increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.

Likelihood Possible Evidence D
4-Androsterone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tri Andro, from the product label.

Primeval Labs

See all Primeval Labs products
Name
Primeval Labs
Pharmacist Counseling Corner

Tri Andro by Primeval Labs: Common Questions

Does Tri Andro by Primeval Labs interact with any medications?
Yes. Based on its ingredients, Tri Andro has a known interaction with 8 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tri Andro contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does 1-Androsterone actually improve athletic performance?
The evidence we have rates it as insufficient to say either way. There's no reliable data showing it boosts athletic performance, so don't count on it doing what the marketing claims.
What are the most common side effects of 1-Androsterone?
The reported ones in studies are abnormal cholesterol levels (higher LDL, lower HDL), liver enzyme elevation, and kidney problems. People taking it for just 4 weeks showed drops in kidney function even though their creatinine stayed in normal range.
Can I take this while pregnant or breastfeeding?
No. All three ingredients carry warnings against pregnancy because of the risk to a developing baby, and breastfeeding safety is either unknown or potentially harmful. If you're pregnant or nursing, avoid this product entirely and talk to your doctor about any hormone-related supplements.
What does 'prohormone' mean?
A prohormone is a compound your body converts into a hormone — in this case, testosterone and related androgens. That's why these ingredients carry serious health risks similar to anabolic steroids, not the mild risks of typical supplements.
What happens if I take Tri Andro with testosterone?
The documented interaction is Moderate severity: both your prescription testosterone and the prohormones in this product convert to the same hormones, which could add up and raise your risk for mood changes, heart problems, kidney damage, or liver damage. You need to clear this with your doctor first.
Is this product safe?
These are hormonal compounds with real health risks and very limited safety testing. Liver strain, kidney problems, and major cholesterol changes have been reported. It's not a straightforward 'yes it's safe' or 'no it's not' — it depends on your health, your medications, and your individual risk factors, which is why you need to talk it over with your doctor or pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tri Andro label
Go deeper

The Full Monographs Behind Tri Andro’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

1-androsterone

Interacts with 8 drugs

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It...

Read the full 1-androsterone monograph → Herb & supplement monograph

4-androsterone

Interacts with 8 drugs

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries...

Read the full 4-androsterone monograph → Herb & supplement monograph

Epiandrosterone

Epiandrosterone is a steroid-related compound (a metabolite of DHEA) sold as a 'prohormone' supplement, mostly for muscle building and athletic performance. There is very little high-quality...

Read the full Epiandrosterone monograph →
Sources

Sources & How We Checked

Tri Andro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

1-androsterone 2 references
  1. Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
  2. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.

See these in context on the 1-androsterone monograph →

4-androsterone 3 references
  1. Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. DHEA — MedlinePlus Source

See these in context on the 4-androsterone monograph →

Epiandrosterone 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Epiandrosterone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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