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Dietary supplement

Methyl Cobalamin Vitamin B-12 5000 mcg Ingredients & Drug Interactions

by Wonder Laboratories

Methyl Cobalamin Vitamin B-12 5000 mcg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Methyl Cobalamin Vitamin B-12 5000 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Methyl Cobalamin Vitamin B-12 5000 mcg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B-12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin B-12 in the form of methylcobalamin, dosed at 5000 mcg per tablet. The remaining ingredients are inactive — mannitol, natural cherry flavors, vegetable stearic acid, vegetable cellulose, citric acid, vegetable magnesium stearate, silica, and stevia — which serve as fillers, binders, and flavorings to make the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: neuronal function and nervous system health.
  • We looked for evidence on: Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Postherpetic neuralgia, Vitamin B12 deficiency, Age-related cognitive decline — and 4 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Postherpetic neuralgia.
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.

Vitamin B-12 is effective for treating B-12 deficiency and Imerslund-Grasbeck disease (a rare genetic condition affecting B-12 absorption). It's also likely effective for cyanide poisoning.

For canker sores and postherpetic neuralgia (nerve pain after shingles), the evidence is less certain — it's possibly effective, meaning there's some promise but not yet solid proof.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B-12 is generally very well tolerated, and your body excretes excess B-12 in your urine, so there's no established upper limit. It's considered safe during pregnancy and breastfeeding at normal recommended amounts — talk with your provider about the right dose for you.

Oral B-12 rarely causes allergic reactions like rash or itching; a few case reports mention contact dermatitis, particularly in people with a cobalt allergy (cobalt is part of the B-12 molecule). When correcting a severe B-12 deficiency, a rare serious effect — low potassium (hypokalemia) — has been reported, but this is extremely uncommon.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin for diabetes, mention this supplement to your doctor — it's a Minor interaction, but your provider should keep an eye on your B-12 levels. No other interactions are documented for the ingredients we have data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This is a straightforward B-12 supplement for people with a deficiency or who need extra B-12 support — especially helpful if you're on metformin and at risk of running low. It's safe and well tolerated for most people.

If you're on any medications, check them against the tool on this page, and talk with your doctor or pharmacist before starting to make sure it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Methyl Cobalamin Vitamin B-12 5000 mcg, straight from the product label.

Brand Wonder Laboratories
Net contents 120 Sublingual Tablet(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 262354
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
IngredientAmount% DV
Vitamin B-125000 mcg83333%

Other ingredients: Mannitol, natural Cherry flavors, Vegetable Stearic Acid, Vegetable Cellulose, Citric Acid, Vegetable Magnesium Stearate, Silica, Stevia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Methylcobalamin is the form of vitamin B-12 active in the central and peripheral nervous system.

Neurologically active vitamin B-12

Precautions

The liver may not convert the common form of vitamin B-12 (cyanocobalamin) into adequate amounts of methylcobalamin needed for proper neuronal functioning.

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Formulation

Conforms to USP <2091> for weight.

Mfg. in an FDA Registered Facility, using Good Manufacturing Practices (GMPs)

Nutritionally supports healthy blood cells & nervous system

Gluten free

Vegetarian/Vegan

Made in USA

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Formula 984

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 tablet daily. Allow tablet to dissolve under tongue.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Methyl Cobalamin Vitamin B-12 5000 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Vitamin B-12

Interacts with
20 drugs
5000 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B-12 monograph & interactions

Other (inactive) ingredients: Mannitol, Natural Cherry flavors, Vegetable Stearic Acid, Vegetable Cellulose, Citric Acid, Vegetable Magnesium Stearate, Silica, Stevia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Methyl Cobalamin Vitamin B-12 5000 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B-12 20

Individual Drug Interactions

The ingredients in Methyl Cobalamin Vitamin B-12 5000 mcg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in Methyl Cobalamin Vitamin B-12 5000 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin B-12

Each ingredient & the kinds of drugs it affects

For each ingredient in Methyl Cobalamin Vitamin B-12 5000 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B-121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B-12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Methyl Cobalamin Vitamin B-12 5000 mcg, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories: Common Questions

Does Methyl Cobalamin Vitamin B-12 5000 mcg by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Methyl Cobalamin Vitamin B-12 5000 mcg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Methyl Cobalamin Vitamin B-12 5000 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is methylcobalamin, and why this form of B-12?
Methylcobalamin is one active form of vitamin B-12 your body can use directly. The facts here focus on B-12 itself — both forms work in your system, but your provider or pharmacist can advise which form suits you best.
Can I take this if I'm pregnant or breastfeeding?
Vitamin B-12 is likely safe during pregnancy and breastfeeding at recommended amounts. B-12 is actually needed during both periods. That said, follow your provider's advice on the right dose for you.
Will this help my B-12 deficiency?
Yes — B-12 supplementation is effective for treating vitamin B-12 deficiency. How quickly you feel better depends on how low you are and your individual absorption, so work with your doctor to monitor your levels.
I'm on metformin. Should I take this?
Metformin can lower your B-12 levels over time, so supplementing may actually help offset that effect. Check with your doctor first — they can decide if this dose is right for you and arrange to monitor your B-12 levels.
What are the side effects?
B-12 is very well tolerated. Oral B-12 rarely causes allergic reactions like rash or itching. Correcting a severe deficiency can rarely trigger low potassium, but this is extremely uncommon.
Can I take too much B-12?
No — your body excretes excess B-12 in urine, so there's no established upper limit. You can't overdose on it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Methyl Cobalamin Vitamin B-12 5000 mcg label
Go deeper

The Full Monographs Behind Methyl Cobalamin Vitamin B-12 5000 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Methyl Cobalamin Vitamin B-12 5000 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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