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Dietary supplement

Methylene Blue Pharmaceutical Grade 0.5% Liquid Ingredients & Drug Interactions

by COMPASS LABORATORY

Methylene Blue Pharmaceutical Grade 0.5% Liquid label
See full label image
Liquid Category: Dietary Supplement
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Jul 17, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking Methylene Blue Pharmaceutical Grade 0.5% Liquid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Methylene Blue Pharmaceutical Grade 0.5% Liquid is a dietary supplement by COMPASS LABORATORY with 1 active ingredient. Its ingredients are commonly taken for methemoglobinemia (a blood disorder), claimed energy or mental focus support, anti-aging or longevity claims.Based on those ingredients, 315 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Methylene Blue. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY

Ask about any prescription or over-the-counter medication and we check it for interactions with Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: methylene blue, a pharmaceutical-grade compound used in medical settings to treat certain conditions. COMPASS LABORATORY states it is USP grade (meeting official pharmaceutical standards), third-party tested, formulated with no formaldehyde, and made in the USA.

The product is a liquid form at 0.5% concentration.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Methylene Blue product and its label doesn't state a use — see Methylene Blue's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts we hold do not include effectiveness ratings for methylene blue as a dietary supplement. We cannot tell you what condition or benefit this product is intended to address or how well evidence supports its use.

The evidence, ingredient by ingredient Methylene Blue

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Methylene blue is a real drug with real risks, and the facts caution against casual self-dosing. Prescription forms are generally well tolerated when used as prescribed, but it's unclear how non-prescription supplemental forms may affect safety.

Common side effects from oral methylene blue include abdominal pain, blue or green urine, diarrhea, painful urination, headache, nausea, and vomiting. Rarer but serious effects include hemolytic anemia and methemoglobinemia (a blood condition that reduces oxygen delivery).

The facts advise against use in pregnancy unless a doctor determines it necessary, and advise avoiding it while breastfeeding because there isn't enough safety data. For children, the data rates it as likely safe, though the decision to give it should be made with a pediatrician.

Side effects, ingredient by ingredient Methylene Blue

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Methylene Blue.
  • The most serious interaction on file is rated Moderate.
  • For scale: 315 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any antidepressant, serotonin-related pain reliever (like tramadol), anticholinergic drug (for overactive bladder, allergies, or cold symptoms), or any other prescription medication. Methylene blue has Moderate interactions with both serotonergic and anticholinergic drugs and has affected 315 individual medications in documented data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Methylene blue is a pharmaceutical ingredient with documented interactions affecting hundreds of medications — most critically serotonergic drugs (antidepressants, some pain relievers) and anticholinergic medications. Before you take this product, especially if you're on any prescription medication, check with your doctor or pharmacist and run your exact drugs through the search tool on this page.

It is not a supplement to start on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 17, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Methylene Blue Pharmaceutical Grade 0.5% Liquid, straight from the product label.

Brand COMPASS LABORATORY
Barcode (UPC) 656043504311
Net contents 1.69 FL OZ (50 ml)
Market status On market
Added to our catalog Jul 17, 2026
Product type Dietary Supplement
Supplement form Liquid
Dietary claims / uses May help boost energy production, Memory protection, Antioxidant
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
Maximum serving Sizes:
UPC/BARCODE
656043504311
IngredientAmount% DV
Methylene Blue----

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Marketing

KEEP YOUR MENTAL FACULTIES SHARP - Our specially-formulated methylene blue for humans may help boost the energy production capabilities.

PROTECT YOUR MEMORY - This pharmaceutical grade methylene blue is packed with antioxidants.

PURITY & POTENCY IN EVERY DROP - Our supplement contains only high purity, USP-grade methylene blue and is independently tested. It has no formaldehyde and meets the standards of the United States Pharmacopeia.

SAFE & CONVENIENT PACKAGING - This methylene blue pharmaceutical grade comes in easy dispense glass bottles. This helps to preserve its potency which can be negatively affected by plastic containers.

Wellness Formula

Other

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

Methylene Blue Pharmaceutical Grade 0.5% Liquid label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Dosage formLiquid Amounts shown are per serving.

Methylene Blue

Interacts with
315 drugs
Form: 0.5% liquid solution, USP grade

Methylene blue is a synthetic dye that is an FDA-approved prescription medicine for a rare blood disorder called methemoglobinemia, and it is also use...

Methylene Blue monograph & interactions
Interaction report

Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY Drug Interactions

Want to check YOUR meds against Methylene Blue Pharmaceutical Grade 0.5% Liquid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
315Drugs
315 Moderate

Ingredients driving the most interactions

Methylene Blue 315

Individual Drug Interactions

The ingredients in Methylene Blue Pharmaceutical Grade 0.5% Liquid interact with 315 drugs. Click any drug to see the details.

1 of the 1 ingredient in Methylene Blue Pharmaceutical Grade 0.5% Liquid interact with drugs. Each result below shows which ingredient is responsible. Methylene Blue

Each ingredient & the kinds of drugs it affects

For each ingredient in Methylene Blue Pharmaceutical Grade 0.5% Liquid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Methylene Blue2 drug types · 315 drugs

Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects. In a case report, a critically-ill male in his mid-60s developed a toxicological process attributed to anticholinergic syndrome following treatment with methylene blue for vasoplegia. Symptoms included anhidrosis, fever, lactic acidosis, mucosal dryness, and pupil dilation. Potential exacerbating factors included renal failure and use of fentanyl intra-operatively.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome. Methylene blue inhibits monoamine oxidase A. Intravenous or intrapulmonary use has resulted in serotonin syndrome, including reported fatalities, in patients taking some serotonergic drugs. This effect has not been reported with oral methylene blue. However, tell patients to avoid taking methylene blue with serotonergic drugs.

Likelihood Possible Evidence C
Methylene Blue full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Methylene Blue Pharmaceutical Grade 0.5% Liquid, from the product label.

COMPASS LABORATORY

See all COMPASS LABORATORY products
Pharmacist Counseling Corner

Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY: Common Questions

Does Methylene Blue Pharmaceutical Grade 0.5% Liquid by COMPASS LABORATORY interact with any medications?
Yes. Based on its ingredients, Methylene Blue Pharmaceutical Grade 0.5% Liquid has a known interaction with 315 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Methylene Blue Pharmaceutical Grade 0.5% Liquid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is methylene blue and what is it used for?
Methylene blue is a pharmaceutical compound traditionally used in medical settings to treat certain conditions. The product facts we hold don't specify what this supplement version is intended to address, so ask your pharmacist or doctor what role they'd expect it to play in your health.
Can I take this while pregnant or breastfeeding?
No, the safety data advises against methylene blue in pregnancy unless your doctor decides it's necessary. There isn't enough safety information to use it while breastfeeding. Talk with your obstetrician or pediatrician if you're considering it during either time.
What side effects might I notice?
Common oral side effects include abdominal pain, blue or green urine, diarrhea, painful urination, headache, nausea, and vomiting. Rarer but serious effects are hemolytic anemia and methemoglobinemia, a blood condition that can reduce oxygen delivery. Stop and contact your doctor if you develop severe symptoms.
Is this safe to take with my medications?
Not without checking first — methylene blue interacts with hundreds of medications, most seriously with antidepressants and anticholinergic drugs. Use the interaction checker on this page with your exact medications, then talk it over with your doctor or pharmacist before starting.
Why does my urine turn blue or green?
That's a normal effect of methylene blue — it gets excreted through urine and colors it blue or green. It's not dangerous, but it can be startling if you're not expecting it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Methylene Blue Pharmaceutical Grade 0.5% Liquid is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Methylene Blue Pharmaceutical Grade 0.5% Liquid label
Go deeper

The Full Monographs Behind Methylene Blue Pharmaceutical Grade 0.5% Liquid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Methylene Blue

Interacts with 315 drugs

Methylene blue is a synthetic dye that is an FDA-approved prescription medicine for a rare blood disorder called methemoglobinemia, and it is also used as a diagnostic dye. Its popular use a...

Read the full Methylene Blue monograph →
Sources

Sources & How We Checked

Methylene Blue Pharmaceutical Grade 0.5% Liquid's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 60 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methylene Blue 60 references
  1. Chebolu E, Gnirke M, St Francis H, Soghoian S, Su MK. Extravasation with methylthioninium chloride. Clin Toxicol (Phila) 2024;62(11):776-778. PubMed
  2. Walter-Sack I, Rengelshausen J, Oberwittler H, et al. High absolute bioavailability of methylene blue given as an aqueous oral formulation. Eur J Clin Pharmacol. 2009;65(2):179-89. PubMed
  3. Akazawa M, Wu YH, Liu WM. Allergy-like reactions to methylene blue following laparoscopic chromopertubation: A systematic review of the literature. Eur J Obstet Gynecol Reprod Biol 2019;238:58-62. PubMed
  4. Aldeghaither S, Deschênes PJF, Samoukovic G. Anticholinergic Toxidrome as a Possible Explanation for Methylene Blue Toxicity. Am J Case Rep 2023;24:e941453. PubMed
  5. Liao YP, Hung DZ, Yang DY. Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia. Vet Hum Toxicol 2002;44(1):19-21.
  6. Bilgin H, Ozcan B, Bilgin T. Methemoglobinemia induced by methylene blue pertubation during laparoscopy. Acta Anaesthesiol Scand 1998;42(5):594-5. PubMed
  7. Kirlangitis JJ, Middaugh RE, Zablocki A, Rodriquez F. False indication of arterial oxygen desaturation and methemoglobinemia following injection of methylene blue in urological surgery. Mil Med 1990;155(6):260-2. DOI
  8. Porat R, Gilbert S, Magilner D. Methylene blue-induced phototoxicity: an unrecognized complication. Pediatrics 1996;97(5):717-21. DOI
  9. Honoré PJ, Deianova N, Loret G, Hemelsoet D. An easily overlooked cause of toxic encephalopathy: methylene blue in a patient on an SSRI. Acta Neurol Belg 2018;118(1):121-122. PubMed
  10. McRobb CM, Holt DW. Methylene blue-induced methemoglobinemia during cardiopulmonary bypass? A case report and literature review. J Extra Corpor Technol 2008;40(3):206-14. DOI
  11. Donaldson CJ, Sequeira Campos M, El-Sayed M. Inadvertent foetal exposure to methylene blue in the first trimester. J Obstet Gynaecol 2020;40(4):573-574. PubMed
  12. Vanhinsbergh L, Uthaya S, Bain BJ. Methylene blue-induced Heinz body hemolytic anemia in a premature neonate. Am J Hematol 2018;93(5):716-717.
  13. Repici A, Di Stefano AF, Radicioni MM, Jas V, Moro L, Danese S. Methylene blue MMX tablets for chromoendoscopy. Safety tolerability and bioavailability in healthy volunteers. Contemp Clin Trials 2012;33(2):260-7. PubMed
  14. Lee DC, Valente JH. Methylene blue dye-induced knee effusion. Am J Emerg Med 1999;17(7):739-40. PubMed
  15. Albert M, Lessin MS, Gilchrist BF. Methylene blue: dangerous dye for neonates. J Pediatr Surg 2003;38(8):1244-5. PubMed
  16. Giladi AM, Kasten SJ. Anaphylactic-like reaction to methylene blue: case report and review of perioperative hypersensitivity reactions. Plast Reconstr Surg 2012;130(1):98e-105e. PubMed
  17. Bleicher RJ, Kloth DD, Robinson D, Axelrod P. Inflammatory cutaneous adverse effects of methylene blue dye injection for lymphatic mapping/sentinel lymphadenectomy. J Surg Oncol 2009;99(6):356-60. PubMed
  18. George M. Methylene-blue-induced hyperbilirubinemia and phototoxicity in a neonate. Clin Pediatr (Phila) 2000;39(11):659-61.
  19. Lam CW, Wong SY. A case of green urine due to a traditional Chinese medicine containing methylene blue. N Z Med J 2010;123(1312):71-6.
  20. Teknos D, Ramcharan A, Oluwole SF. Pulmonary edema associated with methylene blue dye administration during sentinel lymph node biopsy. J Natl Med Assoc 2008;100(12):1483-4. PubMed
  21. Huang WH, Li MJ. Postoperative Serotonin Syndrome Following Administration of Preoperative Intrapulmonary Methylene Blue and Intraoperative Granisetron: A Case Report. Am J Case Rep 2022;23:e936317. PubMed
  22. Basta MN. Postoperative Serotonin Syndrome Following Methylene Blue Administration for Vasoplegia After Cardiac Surgery: A Case Report and Review of the Literature. Semin Cardiothorac Vasc Anesth 2021;25(1):51-56. PubMed
  23. Gilbert B, Akamune IE. A Case of Serotonin Syndrome Caused by the Concomitant Utilization of Methylene Blue and Venlafaxine in an Oncological Patient. J Pharm Pract 2020;33(5):705-707. PubMed
  24. Hashmi AT, Gupta SS, Shankar S, Seneviratne C, Yoon TS, Kupfer Y. Life-Threatening Serotonin Syndrome Due to Methylene Blue-Citalopram Interaction. Am J Ther 2019;26(6):e740-e741. PubMed
  25. Pelletier JP, Transue S, Snyder EL. Pathogen inactivation techniques. Best Pract Res Clin Haematol. 2006;19(1):205-42. PubMed
  26. Francescangeli J, Vaida S, Bonavia AS. Perioperative Diagnosis and Treatment of Serotonin Syndrome Following Administration of Methylene Blue. Am J Case Rep 2016;17:347-51. PubMed
  27. Hencken L, To L, Ly N, Morgan JA. Serotonin Syndrome Following Methylene Blue Administration for Vasoplegic Syndrome. J Card Surg 2016;31(4):208-10. PubMed
  28. Wolvetang T, Janse R, Ter Horst M. Serotonin Syndrome After Methylene Blue Administration During Cardiac Surgery: A Case Report and Review. J Cardiothorac Vasc Anesth 2016;30(4):1042-5. PubMed
  29. Smith CJ, Wang D, Sgambelluri A, Kramer RS, Gagnon DJ. Serotonin syndrome following methylene blue administration during cardiothoracic surgery. J Pharm Pract 2015;28(2):207-11. PubMed
  30. Top WM, Gillman PK, de Langen CJ, Kooy A. Fatal methylene blue associated serotonin toxicity. Neth J Med 2014;72(3):179-81.
  31. McDonnell AM, Rybak I, Wadleigh M, Fisher DC. Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy. J Oncol Pharm Pract 2012;18(4):436-9. PubMed
  32. Grubb KJ, Kennedy JL, Bergin JD, Groves DS, Kern JA. The role of methylene blue in serotonin syndrome following cardiac transplantation: a case report and review of the literature. J Thorac Cardiovasc Surg 2012;144(5):e113-6. PubMed
  33. Sanei ZS, Shahrahmani F, Khaleghi Manesh B, et al. Methylene blue for COVID-19 ARDS: insights from a randomized Clinical Trial. Naunyn Schmiedebergs Arch Pharmacol 2025;398(2):1915-1924. PubMed
  34. Hamidi-Alamdari D, Hafizi-Lotfabadi S, Bagheri-Moghaddam A, et al. METHYLENE BLUE FOR TREATMENT OF HOSPITALIZED COVID-19 PATIENTS: A RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL, PHASE 2. Rev Invest Clin 2021;73(3):190-198. PubMed
  35. Alamdari DH, Moghaddam AB, Amini S, et al. Application of methylene blue -vitamin C -N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial. Eur J Pharmacol 2020;885:173494. PubMed
  36. Guo X, Ding W, Liu L, Yang S. Intradiscal Methylene Blue Injection for Discogenic Low Back Pain: A Meta-Analysis. Pain Pract 2019;19(1):118-129. PubMed
  37. Deng M, Huang H, Ma YG, Zhou Y, Chen Q, Xie P. Intradiskal Injection of Methylene Blue for Discogenic Back Pain: A Meta-Analysis of Randomized Controlled Trials. J Neurol Surg A Cent Eur Neurosurg 2021;82(2):161-165. PubMed
  38. Farrokhi MR, Lotfi M, Masoudi MS, Gholami M. Effects of methylene blue on postoperative low-back pain and functional outcomes after lumbar open discectomy: a triple-blind, randomized placebo-controlled trial. J Neurosurg Spine 2016;24(1):7-15. View abstra PubMed
  39. Wilcock GK, Gauthier S, Frisoni GB, et al. Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial. J PubMed
  40. Rodriguez P, Zhou W, Barrett DW, et al. Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain. Radiology 2016;281(2):516-526. PubMed
  41. Rodriguez P, Singh AP, Malloy KE, et al. Methylene blue modulates functional connectivity in the human brain. Brain Imaging Behav 2017;11(3):640-648. PubMed
  42. Wischik CM, Staff RT, Wischik DJ, et al. Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease. J Alzheimers Dis 2015;44(2):705-20. PubMed
  43. Baddeley TC, McCaffrey J, Storey JM, et al. Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease. J Pharmacol Exp Ther 2015;352(1):110-8. PubMed
  44. Alda M, McKinnon M, Blagdon R, et al. Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study. Br J Psychiatry 2017;210(1):54-60. PubMed
  45. Zhang Z, Zhu Z, Liu H, Chen J, Jin C, Zhang X. A Prospective, Randomized, Controlled Trial of Methylene Blue Injection for Costal Cartilage Harvest Postoperative Analgesia. Aesthet Surg J 2025;45(2):NP65-NP70. PubMed
  46. Soliman M, Salah M, Fadel M, Nasr M, El-Azab H. Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris. Arch Dermatol Res 2021;313(3):173-180. PubMed
  47. Alves RO, Urzedo LOR, de Toledo PTA. Antimicrobial Photodynamic Therapy in Onychomycosis Management: A Systematic Review of Clinical Trials. Photodiagnosis Photodyn Ther. 2025:104640. PubMed
  48. Naylor GJ, Martin B, Hopwood SE, Watson Y. A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis. Biol Psychiatry 1986;21(10):915-20.
  49. Telch MJ, Bruchey AK, Rosenfield D, et al. Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia. Am J Psychiatry 2014;171(10):1091-8. PubMed
  50. Jia W, Li Q, Ni J, Zhang Y, Wu L, Xu L. Efficacy and safety of methylene blue injection for intractable idiopathic pruritus ani: a single-arm metaanalysis and systematic review. Tech Coloproctol 2023;27(10):813-825. PubMed
  51. Xue H, Thaivalappil A, Cao K. The Potentials of Methylene Blue as an Anti-Aging Drug. Cells 2021;10(12):3379. PubMed
  52. Wickramasinghe D, Wickramasinghe N, Samarasekera N, Warusavitarne J. The effect of local infiltration of methylene blue on posthemorrhoidectomy pain: A systematic review and meta-analysis. Curr Probl Surg 2025;67:101752. PubMed
  53. Gureev AP, Sadovnikova IS, Popov VN. Molecular Mechanisms of the Neuroprotective Effect of Methylene Blue. Biochemistry (Mosc) 2022;87(9):940-956. PubMed
  54. Isaev NK, Genrikhs EE, Stelmashook EV. Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer's disease. Rev Neurosci 2024;35(5):585-595. PubMed
  55. Tariq B, Simon SR, Pilz W, Maxim A, Kremer B, Baijens LWJ. Evaluating the safety of oral methylene blue during swallowing assessment: a systematic review. Eur Arch Otorhinolaryngol 2021;278(9):3155-3169. PubMed
  56. US Food and Drug Administration (FDA). PROVAYBLUE® (methylene blue) Prescribing Information. January 2024. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/204630s021lbl.pdf. Accessed July 16, 2025
  57. Gauthier S, Feldman HH, Schneider LS, et al. Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet. 2016;388(10062):2873- PubMed
  58. Lu G, Nagbanshi M, Goldau N, et al. Efficacy and safety of methylene blue in the treatment of malaria: a systematic review. BMC Med. 2018;16(1):59. PubMed
  59. Pelgrims J, De Vos F, Van den Brande J, et al. Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature. Br J Cancer. 2000;82(2):291-4. PubMed
  60. Khokhar RS, Aqil M, Al-Zahrani T, Gelidan A, Al Khayal K. Novel management of methylene blue extravasation: A case report and review of literature. Saudi J Anaesth. 2015;9(2):211-3. PubMed

See these in context on the Methylene Blue monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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