Major interaction on record — check this product against your medications before combining. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

MPO Blue Raspberry Ingredients & Drug Interactions

by Dioxyme

MPO Blue Raspberry label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MPO Blue Raspberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

MPO Blue Raspberry is a dietary supplement by Dioxyme with 5 active ingredients. Its ingredients are commonly taken for athletic performance and endurance, high-intensity exercise capacity, reducing muscle fatigue.Based on those ingredients, 168 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium Beta-Hydroxy-Beta-Methylbutyrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MPO Blue Raspberry by Dioxyme

Ask about any prescription or over-the-counter medication and we check it for interactions with MPO Blue Raspberry by Dioxyme — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MPO Blue Raspberry by Dioxyme

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

MPO Blue Raspberry is a 5-ingredient powder built around three active compounds: Beta-Alanine, Creatine Monohydrate, and Calcium Beta-Hydroxy-Beta-Methylbutyrate (also called HMB-Ca). The remaining two active ingredients — Alpha-Hydroxyisocaproic Acid and Mediator — are also part of the formula.

The powder also contains inactive ingredients (tapioca maltodextrin, citric acid, natural flavors, stevia leaf extract, and silicon dioxide) that serve as fillers, flavorings, and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Build strength, power, endurance and recovery.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle breakdown, Exercise-induced muscle damage, Muscle strength, Physical performance, Muscle breakdown — and 4 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance, Physical performance.

Beta-Alanine is rated Possibly Effective for athletic performance and physical performance. For cognitive benefits — including age-related cognitive decline and general cognitive function — the evidence is insufficient to rate it.

Creatine Monohydrate is Possibly Effective for muscle strength and athletic performance, and also Possibly Effective for sarcopenia and cerebral creatine deficiency syndromes. For Huntington disease and bone density (osteopenia), it appears Possibly Ineffective.

Calcium is Effective for kidney failure, heartburn (dyspepsia), low blood calcium (hypocalcemia), and high potassium (hyperkalemia), and Likely Effective for osteoporosis. We hold no effectiveness data in our records for Alpha-Hydroxyisocaproic Acid or Mediator.

The evidence, ingredient by ingredient Beta-alanine Creatine Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-Alanine is generally well tolerated but commonly causes harmless skin tingling (paresthesia) and flushing, usually starting on the scalp within 20 minutes and lasting about an hour — the effect is dose-dependent and mild at lower doses. The safety data advises against use during pregnancy and breastfeeding.

Creatine Monohydrate is generally well tolerated in healthy adults, though people with kidney problems should be careful. Common side effects are dehydration, diarrhea, stomach upset, muscle cramps, and water retention; rare serious concerns include kidney inflammation and muscle breakdown (rhabdomyolysis).

Safety during pregnancy and breastfeeding has not been established, so it is best avoided. Calcium is generally safe at recommended doses; common side effects are belching, constipation, diarrhea, bloating, and stomach upset.

Calcium is safe during pregnancy and breastfeeding when used at recommended amounts — adequate calcium is important for both. High doses raise theoretical concerns about kidney stones and, very rarely, calcium buildup in blood vessels (calciphylaxis).

Side effects, ingredient by ingredient Beta-alanine Creatine Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 168 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir) — calcium can reduce their effectiveness significantly. Also check if you take levothyroxine (thyroid hormone), sotalol (heart rhythm medication), diltiazem (calcium channel blocker), ceftriaxone (antibiotic), or calcipotriene (psoriasis treatment) — you may need to space doses or avoid combination.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help athletic and physical performance through its Beta-Alanine and Creatine. If you take HIV medications (especially dolutegravir or elvitegravir), a thyroid hormone, a heart rhythm medication, or receive intravenous antibiotics, check your exact medications with your doctor or pharmacist before starting — calcium in this product can interfere with several of them.

Those with kidney disease should talk to their provider, and pregnant or breastfeeding women should discuss it with their healthcare team first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MPO Blue Raspberry, straight from the product label.

Brand Dioxyme
Net contents 480 Gram(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 282184
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MPO Blue Raspberry by Dioxyme, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Gram(s)
Maximum serving Sizes:
32 Gram(s)
Servings per container
30
IngredientAmount% DV
Beta-Alanine2000 mg--
Creatine Monohydrate4500 mg--
Calcium Beta-Hydroxy-Beta-Methylbutyrate3000 mg--
Alpha-Hydroxyisocaproic Acid1500 mg--
Mediator750 mg--

Other ingredients: Tapioca Maltodextrin, Citric Acid, Natural Flavors, Stevia Leaf Extract, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

5 active ingredients Build strength & power Strength Size Endurance Recovery Muscle performance optimizer

Non GMO Gluten free

3rd party tested

Strength. Unrivaled. Feel unstoppable with increased strength, power, endurance and recovery. MPO is a stimulant-free, performance enhancer that improves the way your muscles work. Experience a real athletic difference, not the over-stimulated feel of standard pre-workouts. The synergy of 5 active ingredients in MPO will dramatically increase your strength. Our formula will increase muscle endurance for more sets, reps and time under tension. The 5 ingredients stimulate anabolic mTOR & growth pathways for increased muscle growth. Our anti-catabolic formula improves your recovery by decreasing delayed onset muscle soreness (DOMS) and exercise induced muscle damage (EIMD).

MPO is a stimulant-free, performance enhancer that improves the way your muscles work.

Contains no synthetic coloring or unneeded fillers

Always 3rd party batch tested for quality and safety assurance Produced in a GMP certified facility

Vegan

Non GMO Gluten free

Formula

HMB Mediator PA HICA Beta-alanine Creatine

Keto friendly Paleo friendly

FDA Statement of Identity

Dietary Supplement

General Statements

#thisisme

Ingredient transparency.

Reduce. Reuse. Recycle. Our bag uses 5x less plastic than traditional plastic tubs and is 100% recyclable

Suggested/Recommended/Usage/Directions

Suggested use: Drink 30 minutes prior to exercise. MPO is not meant to be sipped. Drink completely at one time. To gain muscle, we recommend taking MPO daily, even on days off. It is not necessary to cycle on and off MPO. Optimal dosage 100-130 lbs, 1/2 serving 131-190 lbs, 1 serving 191-240 lbs, 1.5 servings 241 lbs +, 2 servings

Precautions

Allergen warning: Manufactured in a facility that processes wheat, milk and soy.

Warning: This product is only intended for healthy adults, 18 years of age or older.

Do not use if pregnant or nursing. Consult with a physician before taking this or any dietary supplement product, especially if you are taking medication or have a medical condition.

Use only as directed.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Mediator PA is a registered trademark of Chemi Nutra. Mediator PA is protected under patents pending by Chemi Nutra.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MPO Blue Raspberry by Dioxyme label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MPO Blue Raspberry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MPO Blue Raspberry by Dioxyme

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta-Alanine

No known
interactions
2000 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

Creatine Monohydrate

No known
interactions
4500 mg per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Monohydrate monograph & interactions

Calcium Beta-Hydroxy-Beta-Methylbutyrate

Interacts with
168 drugs
3000 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium Beta-Hydroxy-Beta-Methylbutyrate monograph & interactions

Alpha-Hydroxyisocaproic Acid

1500 mg per serving

Mediator

750 mg per serving Form: Phosphatidic Acid

Other (inactive) ingredients: Tapioca Maltodextrin, Citric Acid, Natural Flavors, Stevia Leaf Extract, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

MPO Blue Raspberry by Dioxyme Drug Interactions

Want to check YOUR meds against MPO Blue Raspberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
168Drugs
7 Major 143 Moderate 18 Minor

Ingredients driving the most interactions

Calcium Beta-Hydroxy-Beta-Methylbutyrate 168

Individual Drug Interactions

The ingredients in MPO Blue Raspberry interact with 168 drugs. Click any drug to see the details.

1 of the 5 ingredients in MPO Blue Raspberry interact with drugs. Each result below shows which ingredient is responsible. Calcium Beta-Hydroxy-Beta-Methylbutyrate

Each ingredient & the kinds of drugs it affects

For each ingredient in MPO Blue Raspberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium Beta-Hydroxy-Beta-Methylbutyrate18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium Beta-Hydroxy-Beta-Methylbutyrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MPO Blue Raspberry, from the product label.

Dioxyme

See all Dioxyme products
Name
Dioxyme
Pharmacist Counseling Corner

MPO Blue Raspberry by Dioxyme: Common Questions

Does MPO Blue Raspberry by Dioxyme interact with any medications?
Yes. Based on its ingredients, MPO Blue Raspberry has a known interaction with 168 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MPO Blue Raspberry contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product help me with my workouts?
Beta-Alanine and Creatine Monohydrate are both rated Possibly Effective for athletic and physical performance, so they may offer some benefit during exercise. The tingling you feel from beta-alanine is harmless and common — it doesn't mean it's working or not working.
What's the tingling sensation I might feel?
Beta-Alanine commonly causes a harmless pins-and-needles feeling (paresthesia) along with skin flushing, usually starting on your scalp within 20 minutes and lasting about an hour. How strong it is depends on the dose — smaller amounts cause milder tingling or none at all.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information for Beta-Alanine during pregnancy or breastfeeding, so it is best to avoid. Creatine safety hasn't been established in pregnancy and breastfeeding either. Calcium itself can be safe at recommended amounts during both, but because this product contains other ingredients we can't advise on, talk with your doctor or pharmacist for personalized guidance.
What side effects might I experience?
Beta-Alanine commonly causes tingling and flushing. Creatine may cause dehydration, diarrhea, stomach upset, muscle cramps, or water retention. Calcium often causes belching, constipation, diarrhea, bloating, or stomach upset. Most people tolerate these ingredients well.
Is this safe if I have kidney problems?
Creatine requires caution if you have kidney issues — talk with your doctor or pharmacist before taking this product, since creatine is processed by the kidneys and high doses have raised rare concerns about kidney damage.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MPO Blue Raspberry is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MPO Blue Raspberry label
Go deeper

The Full Monographs Behind MPO Blue Raspberry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

MPO Blue Raspberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 161 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
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See these in context on the Creatine monograph →

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  62. US Food and Drug Administration (FDA). Biktarvy Prescribing Information. October 2024. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/210251Orig1s020lbl.pdf. Accessed July 16, 2025.

See these in context on the Calcium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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