Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Multi-Flora Probiotic Ingredients & Drug Interactions

by VitaScript

Multi-Flora Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Multi-Flora Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Multi-Flora Probiotic is a dietary supplement by VitaScript with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Multi-Flora Probiotic by VitaScript

Ask about any prescription or over-the-counter medication and we check it for interactions with Multi-Flora Probiotic by VitaScript — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Multi-Flora Probiotic by VitaScript

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.

Multi-Flora Probiotic contains five active probiotic ingredients: Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium bifidum, Lactobacillus lactis, and Lactobacillus reuteri. These are live beneficial bacteria meant to support gut health.

The capsules also contain inactive ingredients—Jerusalem Artichoke, Cellulose, Modified Cellulose, and Medium Chain Triglyceride—which serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support digestive health and intestinal flora.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance, Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for Lactobacillus acidophilus supports its use for irritable bowel syndrome (IBS), possibly effective help with infections from Helicobacter pylori bacteria, and possibly effective use in preventing or treating antibiotic-associated diarrhea and bacterial vaginosis. Bifidobacterium bifidum is rated possibly effective for IBS and respiratory tract infections.

For other uses listed—such as Alzheimer disease, anxiety, and allergic rhinitis—the evidence is either insufficient or the data lean toward ineffective, so we can't say these ingredients will help with those conditions.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though you should check with your doctor before use because data are limited. The same goes for Bifidobacterium bifidum, which is generally well tolerated in healthy people; however, anyone with a weakened immune system should be cautious and consult their doctor first.

Both probiotics may cause mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea, though these are uncommon. In very rare cases, live probiotics have been associated with serious infections like sepsis or bacteremia, usually in people with severely compromised immunity or underlying illness, but this risk is not well defined for routine use.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, double-check with your pharmacist before starting this product—they may reduce how well the probiotics work. The interactions are Moderate in severity, so timing matters.

Since we couldn't check three of the five ingredients in our data, mention all your medications when you ask.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Multi-Flora Probiotic may help with IBS, antibiotic-related diarrhea, and a couple of bacterial infections if the evidence holds up for you. The main thing to watch: if you're on antibiotics, space out when you take them and this supplement so the antibiotics don't kill the live cultures.

If you have a weakened immune system or take multiple medications, talk to your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Multi-Flora Probiotic, straight from the product label.

Brand VitaScript
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319240
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Multi-Flora Probiotic by VitaScript, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus lactis0 NP--
Lactobacillus reuteri0 NP--

Other ingredients: Jerusalem Artichoke, Cellulose, Modified Cellulose, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take one capsule per day or as directed by a healthcare professional.

Formula

5 Probiotic strains to support digestive health Probiotics are beneficial bacteria that are normally found in our digestive system, and are important for supporting the intestinal flora. The majority of our immune system is closely tied to our digestive tract, making it even more important to support proper gut health. Just one capsule of our Multi-Flora Probiotic contains five different, well-researched strains of "good" bacteria. To guarantee 8 billion active cells at the Best Buy Date, we encapsulate 16 billion cells at time of manufacture.

Five beneficial strains 8 Billion active cells at best by date

Formulation

Contains no artificial colors, flavors or preservatives; no wheat, eggs, peanuts, tree nuts, crustacean shellfish or fish.

We guarantee our supplements for potency and purity

Supports digestive health

Double verified GF Gluten Free

Storage

Store in the refrigerator at all times, before and after opening.

Precautions

To report a serious adverse event, call 1-888-710-0006

Contains: Milk and Soy.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Double verified GF Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Multi-Flora Probiotic by VitaScript label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Multi-Flora Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Multi-Flora Probiotic by VitaScript

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus acidophilus

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Lactobacillus plantarum

0 NP per serving

Bifidobacterium bifidum

Interacts with
182 drugs
0 NP per serving

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance....

Bifidobacterium bifidum monograph & interactions

Lactobacillus lactis

0 NP per serving

Lactobacillus reuteri

0 NP per serving

Other (inactive) ingredients: Jerusalem Artichoke, Cellulose, Modified Cellulose, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Multi-Flora Probiotic by VitaScript Drug Interactions

Want to check YOUR meds against Multi-Flora Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium bifidum 182

Individual Drug Interactions

The ingredients in Multi-Flora Probiotic interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Multi-Flora Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in Multi-Flora Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Multi-Flora Probiotic, from the product label.

VitaScript

See all VitaScript products
Name
E-NutritionStore.com
City
Elkridge
State
MD
ZipCode
21075
Phone Number
443-483-3340
Web Address
E-NutritionStore.com
Pharmacist Counseling Corner

Multi-Flora Probiotic by VitaScript: Common Questions

Does Multi-Flora Probiotic by VitaScript interact with any medications?
Yes. Based on its ingredients, Multi-Flora Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Multi-Flora Probiotic contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will these probiotics work if I'm taking an antibiotic?
Not as well as they could. Antibiotics kill bacteria, including the live cultures in this probiotic. To get the most out of both, ask your pharmacist how far apart to space the doses—usually a few hours is enough.
Does this help with IBS or traveler's diarrhea?
Lactobacillus acidophilus in this product is rated possibly effective for IBS and antibiotic-associated diarrhea. The evidence isn't rock-solid, but it's the strongest claim we have for this product. For other types of diarrhea, the data don't support it.
What if I have a weak immune system?
Bifidobacterium bifidum in particular warrants caution if your immune system is compromised. Talk with your doctor or pharmacist before starting, since there's a rare risk of infection from live organisms in immunocompromised people.
Will it cause bloating or gas?
Some people do report mild gas, bloating, or abdominal discomfort when they first take probiotics, but these side effects are uncommon and usually go away. If they're severe or don't improve, stop and check with your pharmacist.
Is it safe during pregnancy or breastfeeding?
We don't have safety data on file for any of these specific ingredients during pregnancy or breastfeeding. Talk with your doctor or midwife before taking it—they can give you personalized advice based on your situation.
Does this actually have five active ingredients?
Yes, it contains five Lactobacillus and Bifidobacterium strains plus some inactive fillers like cellulose and Medium Chain Triglyceride to hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Multi-Flora Probiotic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Multi-Flora Probiotic label
Go deeper

The Full Monographs Behind Multi-Flora Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

Multi-Flora Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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