Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Multi-Oil Ingredients & Drug Interactions

by GNC Preventive Nutrition

Multi-Oil label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Multi-Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Multi-Oil is a dietary supplement by GNC Preventive Nutrition with 6 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Multi-Oil by GNC Preventive Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Multi-Oil by GNC Preventive Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Multi-Oil by GNC Preventive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Multi-Oil is an 8-ingredient softgel combining several types of beneficial fats. The active ingredients include two omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid), oleic acid (a monounsaturated fat), gamma-linolenic acid and linoleic acid (polyunsaturated fats), alpha-linolenic acid, polyunsaturated fat, and monounsaturated fat.

The softgels also contain inactive ingredients — fish body oil, gelatin, glycerin, flax seed oil, wheat germ oil, evening primrose oil, borage oil, black currant oil, natural lemon flavor, caramel color, vitamin E, and rosemary leaf extract — which serve as the carrier and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: heart health support.
  • We looked for evidence on: Coronary heart disease (CHD), Hypercholesterolemia, Hypertension, Stroke, cardiovascular health, lipid management.
  • The strongest evidence on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Oleic Acid is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Stroke.

Oleic acid, one of this product's active components, is rated possibly effective for high cholesterol (hypercholesterolemia) and for reducing the risk of heart disease (coronary heart disease). For the other active ingredients in this product, we hold no effectiveness ratings in our data.

The evidence, ingredient by ingredient Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid is generally recognized as safe when consumed in normal food amounts, such as from olive oil. However, concentrated supplement doses of oleic acid have not been well studied, particularly in pregnancy and while breastfeeding — food amounts are considered safe, but the safety of higher supplement-level doses isn't established.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take any antidiabetes drugs (blood sugar–lowering medications). Oleic acid in this product may increase their effects, potentially lowering your blood glucose more than intended.

For the other active ingredients, we could not check interaction data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Multi-Oil may be worth considering if you're interested in omega-3 and other beneficial fatty acids for heart and cholesterol support. If you take any blood sugar–lowering medication, check with your doctor or pharmacist first — oleic acid may strengthen those drugs' effects.

Talk it over with your own healthcare provider before starting, especially if you're pregnant, breastfeeding, or taking any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Multi-Oil, straight from the product label.

Brand GNC Preventive Nutrition
Barcode (UPC) 048107073381
Net contents 240 Soft Gel Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 1838
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Multi-Oil by GNC Preventive Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Soft Gel Capsule(s)
Maximum serving Sizes:
3 Soft Gel Capsule(s)
Servings per container
80
UPC/BARCODE
048107073381
IngredientAmount% DV
Calories15 {Calories}--
Calories from Fat15 {Calories}--
Total Fat1.5 g2%
Eicosapentaenoic Acid180 mg--
Docosahexaenoic Acid120 mg--
Saturated Fat0 g--
Polyunsaturated Fat0.5 g--
Gamma-Linolenic Acid43 mg--
Linoleic Acid217 mg--
Oleic Acid270 mg--
Alpha-Linolenic Acid71 mg--
Monounsaturated Fat0.5 g--

Other ingredients: Fish Body Oil, Gelatin, Glycerin, Flax seed Oil, Wheat Germ Oil, Evening Primrose Oil, Borage Oil, Black Currant Oil, natural Lemon flavor, Caramel color, Vitamin E, Rosemary leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF REACH OF CHILDREN

CONTAINS: Fish. Soybeans, Wheat.

Storage

Store in a cool, dry place.

General Statements

A unique conbination of omega-3, 6 and 9 fatty acids

Conforms to USP <2091> for weight.

HEART

Made in the USA

Meets USP <2040> disintegration.

General

CODE 753322 HGG

Formulation

No Sugar, No Starch, No Artifical Colors, No Preservatives, Sodium Free, No Corn, No Dairy, Yeast Free.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Multi-Oil by GNC Preventive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Multi-Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Multi-Oil by GNC Preventive Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Soft Gel Capsule(s) Dosage formSoftgel Capsule Servings per container80 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Eicosapentaenoic Acid

180 mg per serving

Docosahexaenoic Acid

120 mg per serving

Gamma-Linolenic Acid

43 mg per serving

Linoleic Acid

217 mg per serving

Oleic Acid

Interacts with
86 drugs
270 mg per serving

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it...

Oleic Acid monograph & interactions

Alpha-Linolenic Acid

71 mg per serving

Other (inactive) ingredients: Fish Body Oil, Gelatin, Glycerin, Flax seed Oil, Wheat Germ Oil, Evening Primrose Oil, Borage Oil, Black Currant Oil, Natural Lemon flavor, Caramel color, Vitamin E, Rosemary leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Multi-Oil by GNC Preventive Nutrition Drug Interactions

Want to check YOUR meds against Multi-Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Oleic Acid 86

Individual Drug Interactions

The ingredients in Multi-Oil interact with 86 drugs. Click any drug to see the details.

1 of the 6 ingredients in Multi-Oil interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Multi-Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Multi-Oil, from the product label.

GNC Preventive Nutrition

See all GNC Preventive Nutrition products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Multi-Oil by GNC Preventive Nutrition: Common Questions

Does Multi-Oil by GNC Preventive Nutrition interact with any medications?
Yes. Based on its ingredients, Multi-Oil has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Multi-Oil contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is oleic acid and why is it in this product?
Oleic acid is a monounsaturated fat found naturally in foods like olive oil. It's included in Multi-Oil because preliminary research suggests it may help with cholesterol levels and heart health — that's why it's rated possibly effective for both high cholesterol and coronary heart disease.
Does this product have omega-3s?
Yes. Multi-Oil contains two omega-3 fatty acids — eicosapentaenoic acid and docosahexaenoic acid — which are commonly found in fish oil and are often taken for heart and brain support, though we don't have effectiveness ratings for those specific ingredients in our data.
Is this product safe to take while pregnant or breastfeeding?
The small amounts of oleic acid in food are considered safe during pregnancy and breastfeeding, but we don't have good safety data on concentrated supplement-level doses. Talk with your doctor or pharmacist about whether this product is appropriate for you.
Can I take this if I'm on a blood sugar medication?
You should check with your doctor or pharmacist first. Oleic acid in this product may increase how well your diabetes medication works, which could lower your blood glucose more than intended — your provider can help you decide if it's safe and whether any dose adjustment is needed.
Does the product contain any fish?
Yes — fish body oil is listed as an inactive ingredient. If you have a fish allergy, avoid this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Multi-Oil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Multi-Oil label
Go deeper

The Full Monographs Behind Multi-Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Multi-Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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