Interactions on record — worth a quick check against your medications. Based on 10 of 19 ingredients. Check your meds →
Dietary supplement

MyCommunity Extract Ingredients & Drug Interactions

by Host Defense Organic Mushrooms

MyCommunity Extract label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MyCommunity Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MyCommunity Extract is a dietary supplement by Host Defense Organic Mushrooms with 19 active ingredients. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 1,039 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zhu Ling, Reishi, Chaga. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MyCommunity Extract by Host Defense Organic Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with MyCommunity Extract by Host Defense Organic Mushrooms — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MyCommunity Extract by Host Defense Organic Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 19 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1 mL) without saying how much of each component you get.

MyCommunity Extract contains 19 active mushroom ingredients in a proprietary blend, along with water, alcohol, and myceliated brown rice as inactive ingredients. The mushrooms include reishi, maitake, lion's mane, shiitake, cordyceps, chaga, poria (zhu ling), agaricus (royal sun blazei), birch polypore, and several others traditional to Asian herbal practice.

Each contributes compounds like polysaccharides and beta-glucans that the formula is designed to support immune and general wellness function.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Comprehensive immune support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Athletic performance, Bronchitis, Cancer, Cancer-related fatigue — and 4 related terms.
  • The closest evidence on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Poria Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer, Diarrhea.
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Chemotherapy-induced anemia, Laryngeal cancer, Chemotherapy-induced diarrhea.

The evidence base for most ingredients in this blend is limited. Reishi shows insufficient reliable evidence for the conditions we evaluated (altitude sickness, Alzheimer disease, athletic performance) and is possibly ineffective for high cholesterol.

Maitake, lion's mane, chaga, cordyceps, shiitake, and agaricus similarly lack sufficient evidence for most uses in our data—including cognitive function, allergic rhinitis, athletic performance, cancer, and diabetes support. Cordyceps is possibly ineffective for athletic performance.

Because this is a broad-spectrum blend with many unproven individual ingredients, we cannot claim effectiveness for any specific health goal based on the data we hold.

The evidence, ingredient by ingredient Poria Mushroom Reishi Mushroom Maitake Mushroom Chaga Birch Agaricus Mushroom Black Hoof Mushroom Lion's Mane Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these mushrooms are generally well tolerated when used as foods or short-term supplements, but long-term human safety data are sparse. Common side effects reported in trials include gastrointestinal upset (diarrhea, nausea, stomach discomfort, bloating), dizziness, dry mouth, itching, rash, and headache.

Allergic reactions—including rash, allergic rhinitis, asthma, and contact dermatitis—have been reported, especially with reishi spores, birch, shiitake (particularly raw), and agaricus. Rarely, chaga carries a risk of kidney problems if consumed in very large amounts due to its oxalate content; liver injury has been reported in a small number of cancer patients taking agaricus mushroom alongside chemotherapy.

Raw shiitake can cause a distinctive whiplash-like skin eruption. During pregnancy, the data advise against these ingredients; while breastfeeding, safety has not been established.

Talk with your pharmacist or doctor before use if you're pregnant, nursing, or have a history of allergies.

Side effects, ingredient by ingredient Poria Mushroom Reishi Mushroom Maitake Mushroom Chaga Birch Agaricus Mushroom Black Hoof Mushroom Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 10 of the 10 matched ingredients can interact with medications — Poria Mushroom, Birch, Maitake Mushroom, Cordyceps, Shiitake Mushroom, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,039 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking MyCommunity Extract, check your medications against these drug types using the search tool: blood thinners and antiplatelet drugs (moderate risk of increased bleeding), blood pressure medications (moderate risk of low blood pressure), blood sugar medications (moderate risk of low blood sugar), immune-suppressing drugs (moderate risk of reduced effect), sedatives (moderate risk of enhanced drowsiness), anticholinergic and cholinergic drugs (moderate risk of reduced or enhanced effect), and diuretics (minor risk). If you take warfarin specifically, be especially cautious—maitake mushroom has a documented case of increased anticoagulant effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a broad mushroom blend best suited to people looking for general immune support who don't take blood thinners, blood pressure medication, blood sugar medications, or immune-suppressing drugs. If you're on any prescription medications—especially blood thinners like warfarin—or have upcoming surgery, check with your pharmacist before starting.

The safety profile is reasonable for short-term use in otherwise healthy adults, but long-term effects are not well studied.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 13 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MyCommunity Extract, straight from the product label.

Brand Host Defense Organic Mushrooms
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255168
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MyCommunity Extract by Host Defense Organic Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
IngredientAmount% DV
Proprietary Blend1 mL--
Zhu Ling0 NP--
Reishi0 NP--
Agarikon0 NP--
Maitake0 NP--
Chaga0 NP--
Reishi0 NP--
Birch Polypore0 NP--
Royal Sun Blazei0 NP--
Enokitake0 NP--
Mesima0 NP--
Split Gill Polypore0 NP--
Turkey Tails0 NP--
Lion's Mane0 NP--
Maitake0 NP--
Amadou0 NP--
Artist's Conk0 NP--
Oregon Ganoderma0 NP--
Cordyceps0 NP--
Shitake0 NP--

Other ingredients: Water, Alcohol, myceliated Brown Rice

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

The Source Full Spectrum of Active Constituents Grown & Processed in the USA Purity Assured Triple Extracted Optimized, Peak Life Cycle Selection P Value Certified for Maximum Growth

Made with U.S. grown, triple extracted organic mushrooms

Comprehensive Immune Support

Certified Organic by the Washington State Department of Agriculture.

Host defense Mycommunity MyCommunity is the 17 species Host Defense formula originally created by Paul Stamets-the most comprehensive Host Defense extract formula for Supporting Natural Immunity.

General Statements

From the Forest, to our Farm, to You

About the founder Paul Stamets believes in the power of Mycelium, the network of thread-like cells that produces mushrooms. Paul wants everyone to share in the benefits from the Host Defense line of products. Mentored by the greatest mycologists of our time, he integrates and expands upon the knowledge of our ancestors.

Suggested/Recommended/Usage/Directions

Directions for Use: As a dietary supplement, take 1 mL twice per day. Can be taken with food or without, on an empty stomach or as recommended by your healthcare advisor.

Precautions

Consult your healthcare advisor regarding the use of this product during pregnancy.

Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic

Producer Certified Organic Washington State Dept. of Agriculture

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MyCommunity Extract by Host Defense Organic Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MyCommunity Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MyCommunity Extract by Host Defense Organic Mushrooms

These are the 19 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1 mL per serving

Other (inactive) ingredients: Water, Alcohol, Myceliated Brown Rice. These complete the product’s ingredient list but are not active constituents.

Interaction report

MyCommunity Extract by Host Defense Organic Mushrooms Drug Interactions

Want to check YOUR meds against MyCommunity Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,039Drugs
1,027 Moderate 12 Minor

Ingredients driving the most interactions

Zhu Ling 417
Reishi 375
Chaga 327
Lion's Mane 327
Shitake 312

Individual Drug Interactions

The ingredients in MyCommunity Extract interact with 1,039 drugs. Click any drug to see the details.

10 of the 19 ingredients in MyCommunity Extract interact with drugs. Each result below shows which ingredient is responsible. Zhu Ling Reishi Chaga Lion's Mane Shitake Mesima Maitake Cordyceps Royal Sun Blazei Birch Polypore

Each ingredient & the kinds of drugs it affects

For each ingredient in MyCommunity Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Zhu Ling3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Zhu Ling full monograph & interactions

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions

Chaga3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga full monograph & interactions

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions

Shitake2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shitake full monograph & interactions

Mesima3 drug types · 308 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP2E1 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP2E1. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black hoof mushroom might reduce the effects of immunosuppressant medications.
In animal research, polysaccharides from black hoof mushroom and black hoof mushroom extract stimulate immune responses.

Likelihood Possible Evidence D
Mesima full monograph & interactions

Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake full monograph & interactions

Cordyceps3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps full monograph & interactions

Royal Sun Blazei1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Royal Sun Blazei full monograph & interactions

Birch Polypore1 drug type · 75 drugs

Diuretic Drugs

Theoretically, birch might interfere with diuretic therapy.

Likelihood Possible Evidence D
Birch Polypore full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MyCommunity Extract, from the product label.

Host Defense Organic Mushrooms

See all Host Defense Organic Mushrooms products
Name
Fungi Perfecti, LLC
Street Address
PO Box 7634
City
Olympia
State
WA
ZipCode
98507
Phone Number
877-504-6926
Web Address
Hostdefense.com
Pharmacist Counseling Corner

MyCommunity Extract by Host Defense Organic Mushrooms: Common Questions

Does MyCommunity Extract by Host Defense Organic Mushrooms interact with any medications?
Yes. Based on its ingredients, MyCommunity Extract has a known interaction with 1,039 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MyCommunity Extract contains 19 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy or while breastfeeding?
No. The safety data advise against all the mushroom ingredients in this blend during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering this product.
Can this cause allergic reactions?
Yes. Allergic reactions—including rash, itching, allergic rhinitis, asthma, and in rare cases contact dermatitis—have been reported, especially with reishi spores, birch, shiitake, and agaricus. If you have a history of mushroom or mold allergies, mention it to your pharmacist.
What stomach side effects should I expect?
The most common side effects are gastrointestinal: diarrhea, nausea, stomach discomfort, and bloating. In clinical trials, these occurred in a small number of participants. Taking it with food may help. If diarrhea persists or is severe, stop and talk to your pharmacist.
How much of this should I take?
The product facts we hold don't include dosing information. Follow the label directions on your bottle or ask your pharmacist for guidance based on your age and health.
Will this really boost my immune system?
The evidence in our data is insufficient to say so. Lab research suggests some of these mushrooms stimulate immune function, but we don't have reliable human data to confirm they work for immune support or any other specific health claim.
Is there anything else I should know about these ingredients?
We could not check several ingredients in the blend (agarikon, enokitake, mesima, split gill polypore, turkey tails, amadou, and artist's conk) because we hold no data for them. If you have questions about those, ask your pharmacist or contact the manufacturer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MyCommunity Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MyCommunity Extract label
Go deeper

The Full Monographs Behind MyCommunity Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Birch

Interacts with 75 drugs

Birch is a tree whose leaves, bark, and sap are used in traditional remedies, most often as a mild diuretic or for joint and urinary complaints. Solid human evidence is limited, and birch is...

Read the full Birch monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Black Hoof Mushroom

Interacts with 308 drugs

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory...

Read the full Black Hoof Mushroom monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

MyCommunity Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 139 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
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Maitake Mushroom 8 references
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Chaga 9 references
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Birch 4 references
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Agaricus Mushroom 5 references
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Black Hoof Mushroom 6 references
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Lion's Mane Mushroom 6 references
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Cordyceps 14 references
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Shiitake Mushroom 67 references
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See these in context on the Shiitake Mushroom monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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