CordyChi Extract Ingredients & Drug Interactions
by Host Defense Organic Mushrooms
What is this page for?
First and foremost: checking CordyChi Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CordyChi Extract is a dietary supplement by Host Defense Organic Mushrooms with 3 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 502 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Reishi (Ganoderma lucidum s.l.) mycelium extract, fresh Cordyceps (Cordyceps militaris s.l.) mycelium extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against CordyChi Extract by Host Defense Organic Mushrooms
Ask about any prescription or over-the-counter medication and we check it for interactions with CordyChi Extract by Host Defense Organic Mushrooms — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of CordyChi Extract by Host Defense Organic Mushrooms
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CordyChi Extract contains three active ingredients: fresh reishi mushroom mycelium extract, dried reishi mushroom fruit body extract, and fresh cordyceps mycelium extract. The product comes as a liquid and includes water, alcohol, and myceliated brown rice as inactive ingredients.
Does it work?
Not established
The evidence we hold rates reishi mushroom as possibly ineffective for high cholesterol (hyperlipidemia), and shows insufficient reliable evidence for reishi in altitude sickness, Alzheimer disease, or athletic performance. For cordyceps, the data rates it as possibly ineffective for athletic performance and insufficient for sexual function, heart rhythm problems, asthma, lung cancer, and chronic obstructive pulmonary disease (COPD).
In other words, the research we have doesn't establish that this product works for its marketed uses.
How safe is it?
Well-documented data
Both reishi and cordyceps are generally well tolerated in the short term, though long-term safety isn't well studied. Common side effects from reishi include dizziness, dry mouth, itching, nausea, rash, and stomach upset; cordyceps may cause abdominal discomfort, constipation, or diarrhea.
Reishi can also trigger respiratory allergies to its spores, causing sore throat or runny nose. There's a rare case report of liver inflammation possibly linked to cordyceps, though it's unclear whether cordyceps or a contaminant was responsible.
Because safety data is not adequate, reishi and cordyceps are best avoided during pregnancy and breastfeeding — talk with your doctor or pharmacist about your specific situation.
Meds to double-check
Moderate interaction found
If you take blood pressure medications (antihypertensives), blood thinners or antiplatelet drugs, diabetes medications, immunosuppressants, or testosterone therapy, check with your doctor or pharmacist before starting CordyChi Extract. These are the medication types most likely to interact with its reishi and cordyceps content.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
CordyChi Extract may interact with blood pressure drugs, blood thinners, diabetes medications, immunosuppressants, and testosterone therapy — all at Moderate to Minor severity. Before you start this product, check your current medications with your doctor or pharmacist.
The evidence also doesn't establish that this product is effective for the conditions it may be marketed for.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CordyChi Extract, straight from the product label.
| Brand | Host Defense Organic Mushrooms |
|---|---|
| Net contents | 1 Fluid Ounce; 30 mL |
| Market status | On market |
| Date entered into DSLD | Sep 24, 2021 |
| DSLD ID | 255162 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CordyChi Extract by Host Defense Organic Mushrooms, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1 mL | -- |
| fresh Reishi (Ganoderma lucidum s.l.) mycelium extract | 0 NP | -- |
| dried Reishi (Ganoderma lucidum s.l.) fruit body extract | 0 NP | -- |
| fresh Cordyceps (Cordyceps militaris s.l.) mycelium extract | 0 NP | -- |
Other ingredients: Water, Alcohol, myceliated Brown Rice
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
The Source Full spectrum of active constituents Grown & processed in the USA Purity assured Triple extracted Optimized, peak life cycle selection P-Value Certified for Maximum Growth
Supports Stress & Fatigue Reduction
Certified Organic by the Washington State Department of Agriculture.
Host Defense Cordychi A uniquely balanced blend of Cordyceps and Reishi, CordyChi brings the benefit of supporting energy and oxygen uptake with cellular nutrients. Adults with active lifestyles and those who seek balance in a stressful world will breathe easy with CordyChi.
General Statements
From the Forest, to our Farm, to you
About the Founder Paul Stamets believes in the power of Mycelium, the network of thread-like cells that produces mushrooms. Paul wants everyone to share in the benefits from the Host Defense line of products. Mentored by the greatest mycologists of our time, he integrates and expands upon the knowledge of our ancestors.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Made with U.S. grown, triple extracted organic mushrooms
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
USDA Organic
Producer Certified Organic Washington State Dept. of Agriculture
Suggested/Recommended/Usage/Directions
Directions for Use: As a dietary supplement, take 1 mL twice per day. Can be taken with food or without, on an empty stomach or as recommended by your healthcare advisor.
Precautions
Consult your healthcare advisor regarding the use of this product during pregnancy.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CordyChi Extract by Host Defense Organic Mushrooms label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CordyChi Extract by Host Defense Organic Mushrooms
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Water, Alcohol, Myceliated Brown Rice. These complete the product’s ingredient list but are not active constituents.
CordyChi Extract by Host Defense Organic Mushrooms Drug Interactions
HelloPharmacist Interaction Report
CordyChi Extract by Host Defense Organic Mushrooms contains reishi mushroom (in two forms) and cordyceps, both of which interact with medications.
The most serious concern is a Moderate-severity risk: reishi may lower blood pressure further when combined with blood pressure drugs (antihypertensives), potentially causing dizziness or fainting.
Read the full breakdown — every affected drug type, severity by severity
Reishi mushroom also carries Moderate interactions with blood thinners (anticoagulants and antiplatelet drugs) — at higher doses, it may increase bleeding risk — and with diabetes medications, where it could theoretically add to their blood-sugar-lowering effects. Cordyceps adds additional Moderate concerns with blood thinners and with immunosuppressants (drugs that weaken the immune system on purpose, like those after transplant); cordyceps also has a Minor interaction with testosterone replacement therapy.
Altogether, these interactions span 502 individual medications. If you take any drug for blood pressure, blood clotting, blood sugar, immune suppression, or testosterone therapy, run your exact medications through the search tool below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against CordyChi Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in CordyChi Extract interact with 502 drugs. Click any drug to see the details.
2 of the 3 ingredients in CordyChi Extract interact with drugs. Each result below shows which ingredient is responsible. fresh Reishi (Ganoderma lucidum s.l.) mycelium extract fresh Cordyceps (Cordyceps militaris s.l.) mycelium extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Abciximab interactionDried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Abrocitinib interactionFresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acenocoumarol interactionFresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Acetaminophen, Aspirin interactionDried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acetaminophen, Aspirin, Caffeine interactionFresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Acetaminophen, Ibuprofen interactionDried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Acetylsalicylic Acid interactionFresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Alteplase, Tpa interactionFresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionDried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with CordyChi Extract — through 2 ingredients. Tap an ingredient for the detail:
Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fresh Cordyceps (cordyceps Militaris S.l.) Mycelium Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionDried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with CordyChi Extract — through 1 ingredient. Tap an ingredient for the detail:
Dried Reishi (ganoderma Lucidum S.l.) Fruit Body ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Dried Reishi (ganoderma Lucidum S.l.) Fruit Body Extract + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in CordyChi Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
fresh Reishi (Ganoderma lucidum s.l.) mycelium extract
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
fresh Cordyceps (Cordyceps militaris s.l.) mycelium extract
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for CordyChi Extract, from the product label.
Host Defense Organic Mushrooms
See all Host Defense Organic Mushrooms products- Name
- Fungi Perfecti, LLC
- Street Address
- PO Box 7634
- City
- Olympia
- State
- WA
- ZipCode
- 98507
- Phone Number
- 877-504-6926
- Web Address
- Hostdefense.com
CordyChi Extract by Host Defense Organic Mushrooms: Common Questions
Does CordyChi Extract by Host Defense Organic Mushrooms interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Is this product effective for boosting energy or athletic performance?
Can I take this long-term?
What does this product actually contain?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CordyChi Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Reishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph → Herb & supplement monographCordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph →Sources & How We Checked
CordyChi Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Reishi Mushroom 17 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
- Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
- Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
- Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
- Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
- Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
- Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
- Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
- Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
- Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
- Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
- Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
- Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
- Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
- Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
- Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
- Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
- Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
- Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
- Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
- Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
- Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
- Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
- Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
- Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
- Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
- Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
- Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC