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Dietary supplement

MygraFew Ingredients & Drug Interactions

by Nature's Way

MygraFew label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MygraFew against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MygraFew is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against MygraFew by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with MygraFew by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of MygraFew by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

MygraFew contains one active ingredient: feverfew extract. Feverfew is a plant used traditionally for headache relief and inflammation.

The tablet also contains inactive ingredients (vegetable cellulose, stearic acid, silica, vegetable modified cellulose, and vegetarian glycerin) that make up the capsule and help hold it together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Feverfew's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports normal blood vessel tone.
  • We looked for evidence on: Tension headache, migraine, vascular headache, blood flow.
  • The closest evidence on file: Feverfew is rated "Insufficient Reliable Evidence To Rate" for Tension headache (Natural Medicines).

The evidence for feverfew in tension headaches, psoriasis, prurigo nodularis (a skin condition), and rheumatoid arthritis is insufficient to rate its effectiveness. This doesn't mean it doesn't work — it means the reliable clinical trial data we have isn't strong enough yet to draw a solid conclusion either way.

If you're considering MygraFew for one of these uses, talk it over with your doctor or pharmacist about whether it makes sense for you.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated over the short term, though some people experience mouth irritation, allergic reactions, or digestive upset (nausea, heartburn, diarrhea, constipation, bloating, or abdominal pain). Chewing fresh feverfew leaves is more likely to cause mouth sores than commercial preparations like this one.

After stopping long-term feverfew, some people report "post-feverfew syndrome" — anxiety, headaches, and insomnia — so don't stop abruptly if you've been taking it for a while. Feverfew is possibly unsafe during pregnancy because it may stimulate the uterus and its safety is not established.

There isn't enough reliable safety data to know whether it's safe while breastfeeding, so avoid it at that time. Talk with your doctor or pharmacist before use if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking MygraFew, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin) — feverfew may increase bleeding risk. Also flag any medications metabolized by CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2C8, or CYP1A2 enzymes, as feverfew may raise their levels.

This includes many heart drugs, psychiatric medications, pain relievers, and others — use the search tool on this page to check your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

MygraFew is a single-ingredient feverfew supplement that's generally well tolerated but comes with a significant interaction profile — especially with blood thinners and many drugs your liver metabolizes. The evidence for its use in headaches and inflammatory conditions isn't yet strong enough to rate.

If you're on any regular medications, check with your doctor or pharmacist before starting, and avoid it during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MygraFew, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674055915
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 63623
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MygraFew by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
033674055915
IngredientAmount% DV
Feverfew extract86 mg--

Other ingredients: Vegetable Cellulose, Stearic Acid, Silica, Vegetable Modified Cellulose, Vegetarian Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Safety sealed with printed outer shrinkwrap and inner seal. Do not use if either is broken or missing.

Caution: If pregnant, nursing or taking any medications, consult a healthcare professional before use.

Certain individuals may experience oral discomfort/irritation when using this product. If irritation occurs discontinue use immediately.

Keep out of reach of children.

Formulation

Gluten free. No sugar, salt, yeast, corn, wheat, soy, dairy products, artificial flavors or preservatives.

General

LN5591.A02 BLK8191A

FDA Disclaimer Statement

* This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Feverfew extract

Standardized Parthenolide (600 mcg)

Each once daily tablet provides 600 mcg of parthenolide.

Suggested/Recommended/Usage/Directions

Once daily

Recommendation: Adults and children over the age of 6 years old, take 1 tablet daily with water. Best results obtained with continuous use.

General Statements

Supports normal blood vessel tone *

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

2015 Nature's Way Brands, LLC

MygraFew is a standardized feverfew extract that supports normal blood vessel tone.*

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MygraFew by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MygraFew label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MygraFew by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Feverfew extract

Interacts with
929 drugs
86 mg per serving Form: Parthenolide

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Feverfew extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Stearic Acid, Silica, Vegetable Modified Cellulose, Vegetarian Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

MygraFew by Nature's Way Drug Interactions

Want to check YOUR meds against MygraFew?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

Feverfew extract 929

Individual Drug Interactions

The ingredients in MygraFew interact with 929 drugs. Click any drug to see the details.

1 of the 1 ingredient in MygraFew interact with drugs. Each result below shows which ingredient is responsible. Feverfew extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MygraFew with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Feverfew extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MygraFew, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

MygraFew by Nature's Way: Common Questions

Does MygraFew by Nature's Way interact with any medications?
Yes. Based on its ingredients, MygraFew has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MygraFew contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is feverfew used for?
Feverfew is a plant traditionally used for headache relief and inflammation. The evidence for tension headaches and inflammatory conditions like psoriasis and rheumatoid arthritis is not yet strong enough to rate, so we don't know for sure how well it works.
Can I take MygraFew if I'm pregnant or breastfeeding?
No — feverfew is possibly unsafe during pregnancy because it may stimulate the uterus, and there isn't enough safety data to know if it's okay while breastfeeding. Talk with your doctor or pharmacist before use if you're pregnant, planning to become pregnant, or breastfeeding.
What side effects might I get from feverfew?
Most commonly, digestive upset like nausea, heartburn, diarrhea, constipation, bloating, or abdominal pain. Mouth irritation and allergic reactions occur in some people, especially if you chew fresh feverfew leaves. Stopping it after long-term use can cause anxiety, headaches, and insomnia, so don't quit abruptly.
Does MygraFew have a lot of fillers?
MygraFew is a single active ingredient with a small set of inactive ingredients to form the tablet: vegetable cellulose, stearic acid, silica, vegetable modified cellulose, and vegetarian glycerin.
Will feverfew interact with my blood thinner or heart medication?
Possibly — feverfew may increase the effects of blood thinners and many other drugs your liver breaks down. Check your exact medications with your doctor or pharmacist before starting, and use the search tool on this page to see if any of yours are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MygraFew label
Go deeper

The Full Monographs Behind MygraFew’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

MygraFew's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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