Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

N-Balance Ingredients & Drug Interactions

by Physician's Strength

N-Balance label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking N-Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

N-Balance is a dietary supplement by Physician's Strength with 8 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 1,352 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wild Sage, Fennel seed Oil powder, Fenugreek. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against N-Balance by Physician's Strength

Ask about any prescription or over-the-counter medication and we check it for interactions with N-Balance by Physician's Strength — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of N-Balance by Physician's Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (700 mg) without saying how much of each component you get.

N-Balance contains 8 ingredients total. The active ones are fennel seed oil powder, royal jelly (wild, raw, in a 3x potency form), kelp, sage, pantothenic acid (a B vitamin), fenugreek, fennel, and raspberry.

The product also contains two inactive ingredients—cellulose and silica—as binders and fillers. Most of these are herbal extracts and minerals traditionally used for reproductive and hormone-related health.

Pantothenic acid is a B vitamin needed for energy and skin health. Royal jelly is a nutrient-dense secretion from honeybees, and fenugreek and fennel are seeds used in cooking and supplements.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: endocrine and hormonal system support.
  • We looked for evidence on: Dysmenorrhea, Lactation, Male infertility, Menopause symptoms, Adrenal function, Mood stability — and 1 related terms.
  • The strongest evidence on file: Fennel is rated "Possibly Effective" for Dysmenorrhea (Natural Medicines).
  • Also on file: Fenugreek is rated "Possibly Effective" for Dysmenorrhea.
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Lactation.

Fennel is possibly effective for dysmenorrhea (painful periods), though the evidence for bronchitis and anxiety is insufficient. Royal jelly is possibly effective for menopausal symptoms but appears possibly ineffective for hay fever, physical performance, and diabetes.

Sage is possibly effective for menopausal symptoms, high cholesterol, and cognitive function, but possibly ineffective for pain after surgery. Fenugreek is possibly effective for sexual dysfunction, sexual arousal, dysmenorrhea, and diabetes management.

Pantothenic acid is effective for pantothenic acid deficiency itself but possibly ineffective for radiation skin damage, with insufficient evidence for hay fever and several other conditions. Raspberry and kelp have no effectiveness ratings in our data.

The evidence, ingredient by ingredient Fennel Royal Jelly Sage Pantothenic Acid Fenugreek

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fennel and fenugreek are generally well tolerated as food amounts but need caution at supplement doses. The most common side effects from fennel are stomach upset, sun sensitivity, and allergic reactions in sensitive people; rarely, seizures have been reported.

Fenugreek commonly causes stomach pain, bloating, diarrhea, and nausea, and can trigger severe allergic reactions including throat swelling and difficulty breathing in susceptible people. Royal jelly is generally well tolerated but poses a serious risk to anyone with asthma or a history of allergies—it can cause itching, hives, eczema, swelling, and in rare cases, anaphylaxis or life-threatening airway constriction.

Sage is well tolerated as tea or food but concentrated products may cause nausea, vomiting, stomach pain, and diarrhea; seizures are a rare serious risk. Pantothenic acid is considered safe at typical doses, with few side effects.

During pregnancy, fennel and fenugreek should be avoided at medicinal doses, and royal jelly and sage are not recommended due to insufficient safety data or known risks—food amounts of sage are likely acceptable. While breastfeeding, avoid medicinal doses of fennel and sage; fenugreek is possibly safe for lactation but sage traditionally reduces milk supply, so check with your doctor first.

Side effects, ingredient by ingredient Fennel Royal Jelly Sage Pantothenic Acid Fenugreek

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Fennel, Royal Jelly, Sage, Fenugreek.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications.
  • For scale: 1,353 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking N-Balance, double-check your medications against these types: blood thinners and antiplatelet drugs (warfarin, clopidogrel, aspirin, and others)—fennel, fenugreek, and royal jelly may increase bleeding risk; birth control pills and hormone replacement therapy—fennel may reduce their effects; diabetes medications—fenugreek may add to their blood sugar-lowering effects; blood pressure drugs—sage, royal jelly, and fenugreek may alter their effects; and seizure medications, heart drugs, and many others metabolized by liver enzymes (CYP2D6, CYP2C9, CYP2C19, CYP3A4)—sage may raise their levels. Your doctor or pharmacist can review your full medication list against these interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

N-Balance is a multi-ingredient formula that combines herbs and nutrients traditionally used for hormone and reproductive health. Because it contains fennel, fenugreek, sage, and royal jelly—all with documented interactions affecting over 1,300 medications—you should check it carefully against your prescriptions before starting.

Anyone with asthma or a history of allergies should be cautious with royal jelly, and pregnant or breastfeeding people should talk with their doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about N-Balance, straight from the product label.

Brand Physician's Strength
Barcode (UPC) 850032454612
Net contents 90 Vegi Cap(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296828
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for N-Balance by Physician's Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
850032454612
IngredientAmount% DV
Proprietary Blend700 mg--
Fennel seed Oil powder0 NP--
undiluted 3x wild Royal Jelly0 NP--
wild, raw Kelp0 NP--
wild Sage0 NP--
Pantothenic Acid0 NP--
Fenugreek0 NP--
Fennel0 NP--
Raspberry, Wild0 NP--

Other ingredients: Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two capsules daily with or without meals.

Formula

N-Balance is a unique blend of premium undiluted, high-potency royal jelly, wild, raw kelp, and wild mountain spices for supporting the endocrine system. It's a complete formula, ideal for supporting health in every way.

Premium royal jelly-plus

Formulation

Great for stable moods and healthy adrenal response regardless of the age. Achieve healthy hormonal support with N-Balance, inside and out. N-Balance is free of all chemicals, pesticides, and additives. N-Balance is the finest formula for quick results.

N-Balance is free of all chemicals, pesticides, and additives.

Hormone system metabolic support

Doctor's Formula

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

N-Balance by Physician's Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

N-Balance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in N-Balance by Physician's Strength

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

700 mg per serving

Other (inactive) ingredients: Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

N-Balance by Physician's Strength Drug Interactions

Want to check YOUR meds against N-Balance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,352Drugs
1,352 Moderate

Ingredients driving the most interactions

wild Sage 1,296
Fennel seed Oil powder 740
Fenugreek 389
undiluted 3x wild Royal Jelly 174

Individual Drug Interactions

The ingredients in N-Balance interact with 1,352 drugs. Click any drug to see the details.

4 of the 8 ingredients in N-Balance interact with drugs. Each result below shows which ingredient is responsible. wild Sage Fennel seed Oil powder Fenugreek undiluted 3x wild Royal Jelly

Each ingredient & the kinds of drugs it affects

For each ingredient in N-Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

wild Sage14 drug types · 1,296 drugs

Anticholinergic Drugs

Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
wild Sage full monograph & interactions

Fennel seed Oil powder6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel seed Oil powder full monograph & interactions

Fenugreek9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek full monograph & interactions

undiluted 3x wild Royal Jelly2 drug types · 174 drugs

Antihypertensive Drugs

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.

Likelihood Possible Evidence D
undiluted 3x wild Royal Jelly full monograph & interactions
The maker

Brand information

Manufacturer and brand details for N-Balance, from the product label.

Physician's Strength

See all Physician's Strength products
Name
Physician's Strength
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-473-8460
Web Address
www.physicians-strength.com
Pharmacist Counseling Corner

N-Balance by Physician's Strength: Common Questions

Does N-Balance by Physician's Strength interact with any medications?
Yes. Based on its ingredients, N-Balance has a known interaction with 1,352 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
N-Balance contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take N-Balance while pregnant or breastfeeding?
No—fennel and fenugreek should be avoided at medicinal doses during pregnancy because of limited safety data and possible hormone-like effects. Royal jelly and sage are not recommended in pregnancy either. While breastfeeding, avoid medicinal doses of fennel and sage; fenugreek is possibly safe but sage may reduce milk supply. Talk with your doctor or pharmacist before using this product during pregnancy or while breastfeeding.
What is royal jelly, and is it really in this product?
Royal jelly is a nutrient-dense secretion made by honeybees. Yes, this product contains it in a concentrated form labeled 'undiluted 3x wild royal jelly.' While it's generally well tolerated, anyone with asthma or a personal history of allergies should be aware that royal jelly can trigger serious allergic reactions, including anaphylaxis in rare cases.
Can N-Balance help with menopausal symptoms?
Royal jelly and sage are both possibly effective for menopausal symptoms according to the evidence we hold. The other ingredients don't have established effectiveness for that use in our data.
What are the most common side effects I might feel from taking this?
Fennel and fenugreek most commonly cause stomach upset, bloating, or diarrhea. Sage can cause nausea, vomiting, or dizziness. Royal jelly in sensitive people may trigger itching, hives, or eczema. Pantothenic acid is well tolerated with few side effects. Stop and talk to your pharmacist or doctor if you develop any unusual symptoms.
Will N-Balance interfere with my birth control?
Yes—theoretically, the fennel in this product might decrease the effectiveness of birth control pills by competing for estrogen receptors, especially if you're taking large amounts. Check with your doctor or pharmacist before combining them.
Can I take this if I'm on a blood thinner like warfarin?
This product contains multiple ingredients that may increase bleeding risk when combined with blood thinners (fennel, fenugreek, and royal jelly all have antiplatelet or anticoagulant effects). Check with your doctor or pharmacist before starting—they may need to monitor you more closely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

N-Balance label
Go deeper

The Full Monographs Behind N-Balance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Royal Jelly

Interacts with 174 drugs

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...

Read the full Royal Jelly monograph → Herb & supplement monograph

Sage

Interacts with 1,296 drugs

Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore...

Read the full Sage monograph → Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph →
Sources

Sources & How We Checked

N-Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 99 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
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Royal Jelly 14 references
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Sage 27 references
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Pantothenic Acid 11 references
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Fenugreek 30 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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