Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Nanofactor Glutamine Prime Ingredients & Drug Interactions

by 4Life

Nanofactor Glutamine Prime label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nanofactor Glutamine Prime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Nanofactor Glutamine Prime is a dietary supplement by 4Life with 6 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 511 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Arginine, N-Acetyl L-Cysteine, Alpha Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nanofactor Glutamine Prime by 4Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Nanofactor Glutamine Prime by 4Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Nanofactor Glutamine Prime by 4Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Immune Energy Blend” is a proprietary blend — the label gives one combined amount (780 mg) without saying how much of each component you get.

Nanofactor Glutamine Prime contains 6 ingredients, four of which we can identify: L-glutamine, L-arginine, N-acetyl cysteine, and alpha-lipoic acid. NanoFactor and L-alanyl-L-glutamine are also listed; we hold no interaction or effectiveness data for either.

The product is packaged in gelatin capsules with microcrystalline cellulose and stearic acid as inactive ingredients. Each of the four main active ingredients serves a different role.

L-glutamine is an amino acid your body produces naturally and uses for immune function and gut health. L-arginine is another amino acid involved in nitric oxide production and blood vessel function.

N-acetyl cysteine is a modified form of the amino acid cysteine, a building block of the antioxidant glutathione. Alpha-lipoic acid is a compound made by your cells to help convert nutrients into energy and protect against oxidative stress.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Fuel immune system and immune cell function.
  • We looked for evidence on: Athletic performance, Burns, Cancer, Chemotherapy-induced diarrhea, Chemotherapy-induced hepatotoxicity, Chemotherapy-induced lymphocytopenia — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma).
  • Also on file: Alpha-lipoic Acid is rated "Possibly Ineffective" for HIV/AIDS-related dementia.

In our data, L-glutamine is rated effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma. N-acetyl cysteine is rated effective for acetaminophen poisoning, atelectasis (collapsed lung tissue), bronchial diagnostic procedures, and tracheostomy care, and possibly effective for bronchitis.

Alpha-lipoic acid is rated possibly effective for diabetic nerve damage (neuropathy) and high blood lipids, and possibly effective for weight management. We hold no effectiveness ratings in our data for L-arginine, NanoFactor, or L-alanyl-L-glutamine.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports using it for your situation.

The evidence, ingredient by ingredient Glutamine L-arginine N-acetyl Cysteine (nac) Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is rated likely safe in pregnancy and generally well tolerated in healthy adults, though people with kidney or liver disease should use it only under medical supervision. The most common side effects are belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting; a small number of trial participants reported dizziness or headache.

Two cases of mania or hypomania have been reported in people with bipolar disorder taking high-dose glutamine. L-arginine is often well tolerated short-term but can lower blood pressure; safety for self-treatment is not well established, so use only under medical supervision.

Common side effects include abdominal pain, bloating, nausea, diarrhea, headache, and flushing. It's rated possibly safe in pregnancy; lactation safety data are not on file.

N-acetyl cysteine is generally well tolerated at typical doses and rated possibly safe in pregnancy. Common side effects are diarrhea, dry mouth, heartburn, nausea, and vomiting; joint pain was reported in over 15% of participants in one trial.

Lactation safety data are not on file. Alpha-lipoic acid is generally well tolerated but is best used under medical guidance since it can lower blood sugar.

Common side effects are headache, heartburn, nausea, and vomiting. It's rated best avoided during pregnancy and breastfeeding due to insufficient safety information.

A rare but serious concern is insulin autoimmune syndrome, reported in case reports.

Side effects, ingredient by ingredient Glutamine L-arginine N-acetyl Cysteine (nac) Alpha-lipoic Acid

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, L-arginine, Glutamine, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; cancer treatments; diabetes medications.
  • For scale: 511 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take nitroglycerin (Major risk), blood pressure medications including ACE inhibitors or ARBs, blood thinners or antiplatelet drugs like warfarin or aspirin, seizure medications, diabetes drugs, potassium-sparing diuretics, thyroid hormone, chemotherapy including alkylating agents or antitumor antibiotics, chloroquine, or sildenafil (Viagra). If you take activated charcoal, mention it as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may be worth discussing with your doctor if you're interested in amino acid or antioxidant support, but it carries real interaction risks—especially with blood pressure medications, blood thinners, certain seizure drugs, and some chemotherapy agents. If you take any prescription medications, run them through the checker on this page first or talk with your pharmacist before you start.

People with kidney or liver disease, those on blood pressure or heart medications, and pregnant or breastfeeding people should check with their doctor before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nanofactor Glutamine Prime, straight from the product label.

Brand 4Life
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2015
DSLD ID 44531
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nanofactor Glutamine Prime by 4Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
IngredientAmount% DV
L-Glutamine2300 mg--
L-Arginine0 NP--
NanoFactor0 NP--
N-Acetyl L-Cysteine0 NP--
Alpha Lipoic Acid0 NP--
L-Alanyl-L-Glutamine0 NP--
Immune Energy Blend780 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

4Life(R) NanoFactor(R) Glutamine Prime(TM)

~ Features the immune system support for NanoFactor(R) extract ~ Energizes the support of other 4Life Transfer Factor(R) products

What is 4Life NanoFactor Glutamine Prime? 4Life' NanoFactor(R) Glutamine Prime(R) supplies and added source of support for healthy immune cell function, especially during times of increased stress.

In addition, it includes the building blocks of the important antioxidant glutathione, which helps protect cells from oxidation caused by free radicals and features 4Life's NanoFactor(R) extract for enhanced communication between immune cells. Glutamine Prime is an excellent companion product to the complete line of 4Life Transfer Factor(R) products..

2010 4Life Research USA, LLC. All Rights Reserved.

General Statements

Fuel Your Immune System

~ Fuels immune cell activity ~ Supports immune function, especially during times of increased stress.

Glutamine is continually needed and used by the immune system but reserves can become depleted by additional everyday stress, such as exercising and training for athletic events, keeping up with busy day-to-day life, or struggling with various health problems.

PRIMARY SUPPORT: Immune Wellness SECONDARY SUPPORT: Antioxidant

Product information is approved in the United States only.

Key features ~ Features NanoFactor extract that supports enhanced communication between immune cells and helps modulate immune cell response. ~ Provides immune cell fuel from glutamine to help optimize immune cell function, especially during times of increased stress.

Enhances immune system support by promoting your body's ability to more efficiently use the education provided by the other 4Life Transfer Factor products.

Did you know? Glutamine is synthesized by most body tissues and absorbed from food sources such as meat, dairy products, and beans.

Ordering Information Item # 24083 - 180 ct/bottle Item # 27084 - 12 for the price of 11

Formula

Glutamine is an amino acid that serves as a major source of fuel for immune cells.

Glutamine Prime is formulated with the rich energy source of glutamine to help optimize immune cell function.

Includes the building blocks of glutathione, a powerful antioxidant produced in every cell of the body, including immune cells.

CONTAINS INGREDIENTS FROM MILK.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take six (6) capsules daily with 8 oz fluid. For best results, take three (3) capsules, morning and evening.

Precautions

CONTAINS INGREDIENTS FROM MILK.

Seals/Symbols

4Life(R) TOGETHER, BUILDING PEOPLE(R)

4Life(R)

nf(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

General

090710US Label 071210

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nanofactor Glutamine Prime by 4Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nanofactor Glutamine Prime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nanofactor Glutamine Prime by 4Life

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
2300 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Immune Energy Blend

780 mg per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nanofactor Glutamine Prime by 4Life Drug Interactions

Want to check YOUR meds against Nanofactor Glutamine Prime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
511Drugs
1 Major 503 Moderate 7 Minor

Ingredients driving the most interactions

L-Arginine 403
N-Acetyl L-Cysteine 294
Alpha Lipoic Acid 263
L-Glutamine 50

Individual Drug Interactions

The ingredients in Nanofactor Glutamine Prime interact with 511 drugs. Click any drug to see the details.

4 of the 6 ingredients in Nanofactor Glutamine Prime interact with drugs. Each result below shows which ingredient is responsible. L-Arginine N-Acetyl L-Cysteine Alpha Lipoic Acid L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Nanofactor Glutamine Prime with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

N-Acetyl L-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl L-Cysteine full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nanofactor Glutamine Prime, from the product label.

4Life

Name
4Life
Pharmacist Counseling Corner

Nanofactor Glutamine Prime by 4Life: Common Questions

Does Nanofactor Glutamine Prime by 4Life interact with any medications?
Yes. Based on its ingredients, Nanofactor Glutamine Prime has a known interaction with 511 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nanofactor Glutamine Prime contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is glutamine safe if I have kidney disease?
People with kidney or liver disease should use glutamine only under medical supervision. Talk with your doctor about whether it's right for you, since your kidneys help clear it from your body.
Can I take this while pregnant or breastfeeding?
L-glutamine is rated likely safe in pregnancy. L-arginine and N-acetyl cysteine are rated possibly safe in pregnancy, but we don't have enough data to be certain. Alpha-lipoic acid is best avoided during both pregnancy and breastfeeding due to insufficient safety information. Talk with your doctor or midwife about your individual situation before starting.
What are the most common side effects?
The most common side effects across the active ingredients are digestive—bloating, nausea, diarrhea, constipation, and stomach pain. Headache and flushing are also reported. Most people tolerate these ingredients well at normal doses, but side effects may be worse at very high doses.
Does this product actually work for anything?
L-glutamine is proven effective for sickle cell disease and possibly helpful for HIV wasting and recovery after surgery or critical illness. N-acetyl cysteine is proven effective for acetaminophen overdose and possibly helpful for bronchitis. Alpha-lipoic acid is possibly effective for diabetic nerve damage and high cholesterol. We don't have effectiveness data for the other ingredients in this formula.
Why can't you check two of the ingredients?
NanoFactor and L-alanyl-L-glutamine don't have published monographs in our database, so we can't assess their interactions or safety profile. If you want to know more about them, ask the manufacturer or your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nanofactor Glutamine Prime is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nanofactor Glutamine Prime label
Go deeper

The Full Monographs Behind Nanofactor Glutamine Prime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

Nanofactor Glutamine Prime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 211 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
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See these in context on the L-arginine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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