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Dietary supplement

Nattokinase 100 mg Ingredients & Drug Interactions

by NOW

Nattokinase 100 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 100 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattokinase 100 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 100 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattokinase 100 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nattokinase, a protein-digesting enzyme originally derived from natto (a traditional fermented soybean food). It comes in a 100 mg capsule.

The inactive ingredients are microcrystalline cellulose, hypromellose, stearic acid, and silicon dioxide — standard capsule fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cardiovascular health and normal blood flow.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence for nattokinase isn't yet solid enough to make a clear claim. The data we hold shows insufficient reliable evidence to rate it for angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome.

That doesn't mean it won't work — it means the research available today isn't strong enough to say either way.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but because it has blood-thinning effects, caution is wise if you have any bleeding risk. Rare reports of bleeding have been documented, including one case of brain bleeding.

If you're allergic or sensitive to natto, you may have a hypersensitivity reaction; symptoms typically appear within 2 hours of taking it and can range from throat or throat symptoms to severe reactions like anaphylaxis. Not enough safety data exists to recommend nattokinase during pregnancy — the data advises against it.

Safety while breastfeeding is also unknown; the data advises against use.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on blood thinners — prescription anticoagulants (like warfarin, apixaban, dabigatran) or antiplatelet drugs (like aspirin, clopidogrel) — because nattokinase may increase bleeding risk. Also confirm it's okay if you take any high blood pressure medications, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase may appeal to someone interested in cardiovascular support, but the evidence for specific benefits isn't established in our data. If you take blood thinners or high blood pressure medications, this product needs a green light from your doctor or pharmacist first — the interaction risk is real.

Also avoid it during pregnancy or while breastfeeding. Talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 100 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739031402
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 313866
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 100 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
60
UPC/BARCODE
733739031402
IngredientAmount% DV
Nattokinase100 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Stearic Acid, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule 1 to 2 times daily on an empty stomach.

Formula

Nattokinase is an enzyme isolated from Natto, a traditional Japanese fermented soy food. Natto has been consumed for thousands of years for its numerous health promoting properties. More recently, both clinical and non-clinical studies have demonstrated that Nattokinase can help to promote heart and circulatory health by supporting normal blood clotting functions. NOW Nattokinase is derived from non-GMO soy and has 2,000 FUs (Fibrinolytic Units) per 100 mg serving.

2,000 FUs of Activity

Triangle K (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only. Keep out of reach of children.

Do not use if pregnant or nursing, taking “blood thinning” medications (anticoagulants) (such as aspirin, warfarin, heparin) or if you have any ongoing bleeding/coagulation problems (including but not limited to: active ulcer, recent surgery/trauma, hemophilia). Consult physician if you have a medical condition (including uncontrolled high blood pressure [equal to or higher than 200 mmHg/110mmHg]).

Contains soy.

Not manufactured with wheat, gluten, milk, egg, fish, shellfish, tree nut, or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product. Cardiovascular Health Helps Maintain Normal Blood Flow

Vegetarian/Vegan

Made and quality tested in the USA with globally sourced ingredients.

Not manufactured with wheat, gluten, milk, egg, fish, shellfish, tree nut, or sesame ingredients.

Contains no Vitamin K.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP Quality Assured

General Statements

General Health Family owned since 1968.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 100 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 100 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
100 mg per serving Form: Natto Extract

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 100 mg by NOW Drug Interactions

Want to check YOUR meds against Nattokinase 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 100 mg interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 100 mg interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 100 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Nattokinase 100 mg by NOW: Common Questions

Does Nattokinase 100 mg by NOW interact with any medications?
Yes. Based on its ingredients, Nattokinase 100 mg has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take nattokinase if I'm on aspirin?
No — not without talking to your doctor first. There's a documented case of serious brain bleeding in someone who took nattokinase while on low-dose aspirin. Both substances thin the blood, and together they raised the bleeding risk significantly.
Will nattokinase lower my blood pressure?
It might. Some research suggests nattokinase can reduce both systolic and diastolic blood pressure. If you're already on blood pressure medication, combining them could push your pressure too low. Check with your doctor before starting.
What does nattokinase actually do?
Nattokinase is an enzyme from fermented soybeans. It has blood-thinning properties — it can break down blood clots and affect how blood clots form — but we don't have strong enough evidence yet to confirm it works for specific conditions like heart disease or angina.
Is it safe in pregnancy?
No. The safety data advises against using nattokinase during pregnancy because there isn't enough research to know it's safe.
Can I take it while breastfeeding?
The safety data advises against it — there's not enough information to know whether it's safe while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you.
What if I'm allergic to soy?
Nattokinase comes from fermented soybeans, so if you have a soy allergy or sensitivity to natto specifically, you may have a reaction. Symptoms usually start within 2 hours and can range from throat irritation to severe allergic reactions. Avoid it if you know you react to natto or soy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattokinase 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 100 mg label
Go deeper

The Full Monographs Behind Nattokinase 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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