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Dietary supplement

Nattokinase 50 mg NSK-SD 1000 FU Ingredients & Drug Interactions

by Allergy Research Group

Nattokinase 50 mg NSK-SD 1000 FU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 50 mg NSK-SD 1000 FU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 50 mg NSK-SD 1000 FU is a dietary supplement by Allergy Research Group with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: nattokinase, a protein enzyme derived from natto (fermented soybeans). The capsule also holds three inactive ingredients — hydroxypropyl methylcellulose, microcrystalline cellulose, and L-leucine — which are fillers and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: heart and circulatory health support.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Peripheral arterial disease (PAD), Venous insufficiency — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD), and more.

The evidence we hold for nattokinase doesn't establish that it works for any of the conditions it's marketed for — angina, atherosclerosis, cardiovascular disease, cancer, and chronic fatigue syndrome all carry a rating of insufficient reliable evidence. That doesn't mean it won't help; it means the research so far isn't robust enough to say one way or another.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term. Because of its blood-thinning effects, it does carry a caution for anyone with bleeding risks or a history of hemorrhage.

Rare reports link it to bleeding events, and people allergic to natto or its components can have severe hypersensitivity reactions, including anaphylaxis — symptoms can show up within 2 hours of taking it. The safety data advises against nattokinase during pregnancy and breastfeeding, so avoid it during those times.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your own doctor or pharmacist if you're taking blood thinners or antiplatelet medications like warfarin, clopidogrel, or aspirin — nattokinase can increase bleeding risk. Also confirm it's okay if you're on blood pressure medications, since nattokinase may lower your pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase is an option if you're interested in its potential cardiovascular effects, but the evidence for any particular benefit is still uncertain. The real concern is that it thins the blood and lowers pressure, so if you're on blood thinners or blood pressure drugs, you'll need to clear it with your doctor or pharmacist first.

If you've ever had a severe allergic reaction to natto or soy products, skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 50 mg NSK-SD 1000 FU, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947752917
Net contents 300 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233399
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
150
UPC/BARCODE
713947752917
IngredientAmount% DV
Nattokinase100 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Isolated, purified and encapsulated nattokinase, an enzyme derived from boiled soybeans and a selected, patented strain of Bacillus subtilis natto.

Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

Nattokinase NSK-SD is vegetarian, non-irradiated, and free of vitamin K2.

Each batch is tested to ensure potency.

Brand IP Statement(s)

NSK-SD is a trademark of Japan BioScience Laboratory.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 2 capsules two times daily initial dose, or as directed by a healthcare practitioner. May be taken with or without food. Take with 8 to 10 ounces of water.

Precautions

If taken with anticoagulant drugs, use under medical supervision.

Contraindicated in any condition associated with bleeding.

Contains: Soy.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place, tightly capped.

General Statements

Product of Japan.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 50 mg NSK-SD 1000 FU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
100 mg per serving Form: Soy

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group Drug Interactions

Want to check YOUR meds against Nattokinase 50 mg NSK-SD 1000 FU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 50 mg NSK-SD 1000 FU interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 50 mg NSK-SD 1000 FU interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 50 mg NSK-SD 1000 FU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 50 mg NSK-SD 1000 FU, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearch.com
Pharmacist Counseling Corner

Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group: Common Questions

Does Nattokinase 50 mg NSK-SD 1000 FU by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, Nattokinase 50 mg NSK-SD 1000 FU has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 50 mg NSK-SD 1000 FU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take nattokinase if I'm on aspirin?
You should not start it without talking to your doctor or pharmacist first. A case report documents brain hemorrhage in someone who added nattokinase to low-dose aspirin, so this combination needs medical oversight before you proceed.
What is nattokinase, and where does it come from?
It's an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. That fermentation is what creates the enzyme and gives natto its sticky texture.
Does nattokinase actually lower blood pressure?
Some clinical research suggests it may lower systolic and diastolic blood pressure, but the evidence isn't strong enough to say for certain. If you take blood pressure medication, mention this to your doctor before adding nattokinase.
Is nattokinase safe during pregnancy or breastfeeding?
The safety data advises against it during both pregnancy and breastfeeding, so avoid it during those times. Talk with your doctor or pharmacist about options if you're interested in cardiovascular support during pregnancy.
What's the difference between nattokinase and other blood thinners?
Nattokinase is a supplement enzyme, not a prescription blood thinner like warfarin. But it does have blood-thinning effects, which is why combining it with prescription anticoagulants or antiplatelets needs careful coordination with your doctor.
Can I have an allergic reaction to nattokinase?
Yes — rare hypersensitivity reactions have been reported, especially in people sensitive to natto or soy. Symptoms like throat and airway swelling can show up within 2 hours. If you've reacted to natto before, do not take this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 50 mg NSK-SD 1000 FU label
Go deeper

The Full Monographs Behind Nattokinase 50 mg NSK-SD 1000 FU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 50 mg NSK-SD 1000 FU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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