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Dietary supplement

Nattovena Pure Nattokinase Ingredients & Drug Interactions

by Arthur Andrew Medical

Nattovena Pure Nattokinase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattovena Pure Nattokinase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattovena Pure Nattokinase is a dietary supplement by Arthur Andrew Medical with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattovena Pure Nattokinase by Arthur Andrew Medical

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattovena Pure Nattokinase by Arthur Andrew Medical — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattovena Pure Nattokinase by Arthur Andrew Medical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Nattovena Pure Nattokinase is a single-ingredient supplement: nattokinase, an enzyme extracted from natto (fermented soybeans). It's designed to support circulation and cardiovascular function through its blood-thinning and clot-dissolving properties.

The capsule also contains cellulose as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: circulatory and heart health.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence for nattokinase's effectiveness for specific conditions — angina, atherosclerosis, cancer, cardiovascular disease, and chronic fatigue syndrome — is insufficient to make a reliable rating at this time. If you're considering it for a particular health concern, talk with your doctor or pharmacist about whether the current evidence supports its use for your situation.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but because of its blood-thinning effect, caution is warranted if you have any bleeding risk or a history of bleeding disorders. Rare cases of severe bleeding, including brain hemorrhage, have been reported.

Some people are sensitive to natto or nattokinase itself and may have hypersensitivity reactions, including anaphylaxis; symptoms typically appear within 2 hours of taking it and affect the throat and airway. There isn't enough safety data to use nattokinase during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take blood thinners (anticoagulants or antiplatelets) like warfarin, aspirin, or clopidogrel — moderate risk of increased bleeding. Also flag any blood pressure medications you're on — nattokinase may lower your blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase may help support circulation, but the evidence for specific health claims isn't yet established. If you take blood pressure medications or blood thinners, check with your own doctor or pharmacist before starting — the combination could increase your bleeding risk or drop your blood pressure too low.

If you have a natto allergy or unexplained bleeding history, this product isn't right for you. Your healthcare provider can help you decide if it fits your needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattovena Pure Nattokinase, straight from the product label.

Brand Arthur Andrew Medical
Barcode (UPC) 855571001754
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 296849
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattovena Pure Nattokinase by Arthur Andrew Medical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
45
UPC/BARCODE
855571001754
IngredientAmount% DV
Nattokinase0 NP--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Many Asian cultures exhibit superior cardiovascular health in comparison to average US adults, which is widely attributed to a diet higher in natural food-based enzymes. The Japanese have consumed a dish known as Natto for centuries which contains the heart healthy enzyme nattokinase. Nattovena is one of the world's strongest pure-nattokinase products on the market, rated at 4,000 fibrinolytic (fibrin-dissolving) units of activity per capsule. Nattovena supports circulatory and heart health by supporting normal Fibrin Levels. Fibrin is a protein that develops in excess as we age and plays a significant role in our health and general well-being. Nattovena is a powerful blood-cleansing enzyme, formulated to help maintain normal cardiovascular health.

Pure Nattokinase 4,000 FUs Per Capsule

Star-K (Kosher)

Suggested/Recommended/Usage/Directions

Suggested Use: Take Nattovena with 8 oz of water on an empty stomach, or as directed by a healthcare practitioner. Maintenance: 2 Capsules per day. Increased Support: 4 Capsules per day.

Precautions

Warning: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing.

Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Formulation

Circulatory and Heart Health Normal Blood Cleansing Normal Blood Viscosity

Nattovena is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives.

Certified Vegan American Vegetarian Association

Storage

Store in a cool dry place with lid tightly closed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Certified Vegan American Vegetarian Association Star-K (Kosher) Non GMO Tested Gras Generally Recognized As Safe

General Statements

For more information about Nattovena, please call 800-448-5015 or visit www.arthurandrew.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattovena Pure Nattokinase by Arthur Andrew Medical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattovena Pure Nattokinase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattovena Pure Nattokinase by Arthur Andrew Medical

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
0 NP per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattovena Pure Nattokinase by Arthur Andrew Medical Drug Interactions

Want to check YOUR meds against Nattovena Pure Nattokinase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattovena Pure Nattokinase interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattovena Pure Nattokinase interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattovena Pure Nattokinase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattovena Pure Nattokinase, from the product label.

Arthur Andrew Medical

See all Arthur Andrew Medical products
Name
Arthur Andrew Medical
Street Address
8350 E Raintree Dr #101
City
Scottsdale
State
AZ
ZipCode
85260
Phone Number
800-448-5015
Web Address
www.arthurandrew.com
Pharmacist Counseling Corner

Nattovena Pure Nattokinase by Arthur Andrew Medical: Common Questions

Does Nattovena Pure Nattokinase by Arthur Andrew Medical interact with any medications?
Yes. Based on its ingredients, Nattovena Pure Nattokinase has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattovena Pure Nattokinase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
Not without checking first. There's a documented case of serious brain bleeding when nattokinase was added to low-dose aspirin. Talk with your doctor or pharmacist before combining them — they can assess your individual bleeding risk.
What is nattokinase, and where does it come from?
Nattokinase is an enzyme from natto, a traditional Japanese fermented soybean food. It's isolated and concentrated into supplement form. It works as a natural blood thinner and may help dissolve clots.
Is it safe if I have a soybean allergy?
Be cautious. Some people allergic to natto have had anaphylaxis-type reactions to nattokinase. If you have a soybean or natto allergy, avoid this product or talk with your doctor first.
Can I take this during pregnancy?
There isn't enough safety data, so it's best avoided during pregnancy. Talk with your doctor or pharmacist about what's safe for you.
What conditions does this actually help?
The evidence for nattokinase in angina, atherosclerosis, cardiovascular disease, cancer, and chronic fatigue isn't solid enough yet to make reliable claims. Your doctor can discuss whether it might be worth trying for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nattovena Pure Nattokinase is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattovena Pure Nattokinase label
Go deeper

The Full Monographs Behind Nattovena Pure Nattokinase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattovena Pure Nattokinase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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