Tropical Papaya Ingredients & Drug Interactions
by Country Life
What is this page for?
First and foremost: checking Tropical Papaya against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Tropical Papaya is a dietary supplement by Country Life with 4 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Tropical Papaya by Country Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Tropical Papaya by Country Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Tropical Papaya by Country Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Tropical Papaya contains four active ingredients: papain and protease (both protein-digesting enzymes), papaya (the whole fruit in supplement form), and alpha-amylase (which we cannot fully check). Papain and the papaya itself are traditionally used to aid digestion.
The product also includes several inactive ingredients like fructose, mannitol, and cellulose that serve as fillers and binders to hold the supplement together.
Does it work?
Not established
The evidence backing these ingredients isn't established in our data. Papain has been studied for cancer, dental cavities, skin damage from radiation, muscle soreness, shingles, and parasitic infections—but the evidence is insufficient to rate it for any of these uses.
Similarly, papaya has been evaluated for aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes with insufficient evidence in each case. Protease and alpha-amylase have no effectiveness ratings on file.
If you're considering this product for a specific health goal, talk with your pharmacist about what the evidence actually shows.
How safe is it?
Well-documented data
When taken at normal doses for short periods, papain is generally well tolerated, though some people may experience allergic reactions like itchy eyes, sneezing, or stomach cramps. High doses carry rare but serious risks including severe stomach inflammation and even esophageal perforation.
Protease is also generally well tolerated but may cause digestive upset or allergic reactions in sensitive individuals. Both ingredients can trigger respiratory allergies with airborne exposure.
Pregnant people should avoid concentrated papain and unripe papaya products—the safety data advises against them. For breastfeeding, there isn't enough reliable safety information for either papain or protease supplements, so they're best avoided unless a doctor recommends otherwise.
Meds to double-check
Moderate interaction found
If you take warfarin (a blood thinner), diabetes medications, amiodarone (a heart rhythm drug), or levothyroxine (thyroid medication), check with your pharmacist before starting this product—papain and papaya interact with all of these at Moderate severity. We have no documented interactions for protease or alpha-amylase.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is worth a careful medication check if you take warfarin, diabetes drugs, amiodarone, or levothyroxine. If you're pregnant or breastfeeding, talk with your pharmacist before starting it.
The active ingredients haven't been proven effective for any condition in our data, so be clear on why you're considering it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Tropical Papaya, straight from the product label.
| Brand | Country Life |
|---|---|
| Barcode (UPC) | 015794053842 |
| Net contents | 500 Chewable Wafer(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 326825 |
| Product type | Other Combinations |
| Supplement form | Other (e.g. Tea Bag) |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Tropical Papaya by Country Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Added Sugars | 1 Gram(s) | -- |
| Total Sugars | 1 Gram(s) | -- |
| Papain | 28 mg | -- |
| Protease | 24 mg | -- |
| Papaya | 22 mg | -- |
| Alpha-Amylase | 24 mg | -- |
Other ingredients: Fructose, Mannitol, Cellulose, Stearic Acid, Starch, Maltodextrin, Glycine, Papaya Flavor, Natural, Magnesium Stearate, Silica, Pineapple Flavor, Natural
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Digestive enzymes, such as those naturally found in papaya, papain and protease are essential to the body's absorption of food nutrients. This product is made from real papaya and comes as delicious, chewable wafers.
Yes kosher
From whole papaya
General Statements
Available in 200 and 500 wafers.
Yes recyclable packaging
USP- United States Pharmacopoeia
Yes manufacturing supports wind power
Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Yes certified gluten-free by gfco.org No yeast or wheat No soy, milk or salt No artificial colors, flavors or sweeteners
Yes certified vegan by the AVA
This product has been manufactured at a GMP registered facility.
Certified gluten-free
Digestive enzyme support
Seals/Symbols
Certified B Corporation GF Certified Gluten-free K (Kosher)
Brand IP Statement(s)
Established 1971 Country Life
Suggested/Recommended/Usage/Directions
Directions: Adults chew four (4) wafers after each meal, up to three times a day.
Precautions
As a reminder, discuss the supplements and medications that you take with your health care providers. Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.
Stop using and consult a doctor if any adverse reactions occur. Do not accept if seal is broken.
Keep out of the reach of children.
Storage
Store in a dry place between 59 degrees - 86 degrees F.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Tropical Papaya by Country Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Tropical Papaya by Country Life
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Wafer(s) Dosage formOther (e.g. Tea Bag) Servings per container125 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Papain
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Papain monograph & interactionsProtease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsPapaya
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Papaya monograph & interactionsAlpha-Amylase
Other (inactive) ingredients: Fructose, Mannitol, Cellulose, Stearic Acid, Starch, Maltodextrin, Glycine, Papaya Flavor, Natural, Magnesium Stearate, Silica, Pineapple Flavor, Natural. These complete the product’s ingredient list but are not active constituents.
Tropical Papaya by Country Life Drug Interactions
HelloPharmacist Interaction Report
Tropical Papaya by Country Life contains ingredients that interact with several medications you should know about.
The most serious concern is papain, one of its active enzymes, which can increase the effects and side effects of warfarin (a blood thinner). One patient who was stable on warfarin developed dangerously high levels after taking a papain-containing supplement—this is a Moderate severity interaction that needs checking if you're on that medication.
Read the full breakdown — every affected drug type, severity by severity
The papaya ingredient itself has its own set of interactions to watch for. It can add to the effects of diabetes medications, potentially lowering your blood sugar more than intended.
Papaya extract may also raise the levels of amiodarone (a heart rhythm medication), and theoretically interfere with how well levothyroxine (thyroid medication) works in your body. These are all Moderate severity interactions.
We couldn't check alpha-amylase, one of the four active ingredients, because we hold no interaction data for it. The protease enzyme also has no documented interactions in our data, though that doesn't mean none exist.
Use the medication checker below to run through your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Tropical Papaya?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Tropical Papaya interact with 92 drugs. Click any drug to see the details.
2 of the 4 ingredients in Tropical Papaya interact with drugs. Each result below shows which ingredient is responsible. Papaya Papain
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Papaya + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Tropical Papaya — through 1 ingredient. Tap an ingredient for the detail:
PapayaAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Tropical Papaya with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Papaya
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Tropical Papaya, from the product label.
Country Life
See all Country Life products- Name
- Country Life, LLC
- Street Address
- 180 Vanderbilt Motor Parkway
- City
- Hauppauge
- State
- NY
- ZipCode
- 11788
- Web Address
- CountryLifeVitamins.com
Tropical Papaya by Country Life: Common Questions
Does Tropical Papaya by Country Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
What does papain actually do?
I'm allergic to latex. Should I avoid this?
What side effects might I notice?
Is it safe to breastfeed while taking this?
Can this help with digestion?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Tropical Papaya is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Tropical Papaya’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Papain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographPapaya
Interacts with 92 drugsPapaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...
Read the full Papaya monograph →Sources & How We Checked
Tropical Papaya's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Papaya 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
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