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Dietary supplement

NiaCel Ingredients & Drug Interactions

by Thorne

NiaCel label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NiaCel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

NiaCel is a dietary supplement by Thorne with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside Chloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NiaCel by Thorne

Ask about any prescription or over-the-counter medication and we check it for interactions with NiaCel by Thorne — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NiaCel by Thorne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

NiaCel is a single-ingredient supplement containing nicotinamide riboside chloride, a compound related to niacin (vitamin B3) that your cells use to produce energy. Nicotinamide riboside is meant to boost NAD+ (nicotinamide adenine dinucleotide), a coenzyme involved in cellular energy and aging-related processes.

The capsule also contains inactive ingredients: hypromellose, microcrystalline cellulose, leucine, and silicon dioxide — these are binders, thickeners, and fillers with no active role.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain health, healthy aging and metabolism.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Parkinson disease, neurodegeneration, cognitive function.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Parkinson disease.

The evidence for nicotinamide riboside in age-related cognitive decline, macular degeneration, Alzheimer's disease, athletic performance, fatty liver disease, and heart failure is insufficient to rate. This means clinical research hasn't yet established whether it works for these uses.

More robust trials are needed before we can say whether NiaCel is effective for any of these purposes.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears well tolerated in short-term studies, though long-term safety isn't fully known. The most common side effects reported in trials are bloating, muscle pain, nausea, itching, sweating, and temporary changes in bowel habits.

A few people have reported leg cramps or mild muscle soreness in specific trials. During pregnancy, there isn't enough safety data, so it's best to avoid it.

The same applies to breastfeeding — the data isn't there to say it's safe. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding before taking this product.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications with your doctor or pharmacist before taking NiaCel. Nicotinamide riboside may add to the blood-pressure-lowering effect of these drugs, theoretically raising the risk of low blood pressure (hypotension).

We could not check for interactions with other ingredients because this product contains only nicotinamide riboside.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

NiaCel is a single-ingredient NAD+ booster that appears generally well tolerated short-term, but evidence for its effectiveness in the marketed uses is insufficient. If you take blood pressure medication, check with your doctor or pharmacist before starting, since nicotinamide riboside may theoretically lower blood pressure further.

Avoid it during pregnancy and while breastfeeding due to limited safety data. For personalized advice about whether NiaCel is right for you, talk it over with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NiaCel, straight from the product label.

Brand Thorne
Barcode (UPC) 693749004677
Net contents 60 Capsule(s)
Market status Off market
Date entered into DSLD Oct 25, 2018
DSLD ID 182671
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NiaCel by Thorne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
693749004677
IngredientAmount% DV
Nicotinamide Riboside Chloride125 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Leucine, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Brain/Nerves Healthy aging Metabolism

T exclusive

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily or as recommended by your health-care practitioner.

Precautions

Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Storage

Store tightly sealed in a cool, dry place.

Seals/Symbols

Gluten free NSF Certified for Sport

Formulation

Gluten free

Formula

Nicotinamide Riboside

This product contains ChromaDex Inc.’s proprietary Nicotinamide Riboside ingredient, Niagen.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Niagen is a registered trademark of ChromaDex, Inc. Patent: See ChromaDexPatents.com.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

SP642 LSP64206

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NiaCel by Thorne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NiaCel label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NiaCel by Thorne

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Nicotinamide Riboside Chloride

Interacts with
172 drugs
125 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside Chloride monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

NiaCel by Thorne Drug Interactions

Want to check YOUR meds against NiaCel?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Nicotinamide Riboside Chloride 172

Individual Drug Interactions

The ingredients in NiaCel interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in NiaCel interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside Chloride

Each ingredient & the kinds of drugs it affects

For each ingredient in NiaCel with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide Riboside Chloride1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside Chloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NiaCel, from the product label.

Thorne

See all Thorne products
Name
Thorne Research, Inc.
Phone Number
1-800-228-1966
Pharmacist Counseling Corner

NiaCel by Thorne: Common Questions

Does NiaCel by Thorne interact with any medications?
Yes. Based on its ingredients, NiaCel has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NiaCel contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does nicotinamide riboside actually do?
Nicotinamide riboside is a form of vitamin B3 that your cells convert into NAD+, a coenzyme that helps produce energy and supports certain aging-related processes in your body. That's why it's marketed for things like athletic performance and age-related conditions — but the evidence that it actually works for those uses isn't established yet.
Can I take NiaCel if I'm pregnant or breastfeeding?
No — there isn't enough safety data on nicotinamide riboside during pregnancy or breastfeeding, so it's best to avoid it. Talk with your doctor or pharmacist about safer options if you're pregnant, planning pregnancy, or nursing.
What side effects should I watch for?
The most common ones reported in trials are bloating, nausea, muscle pain, itching, sweating, and temporary changes in bowel habits. A few people have also reported leg cramps or mild muscle soreness. Stop taking it and contact your healthcare provider if you experience bothersome effects.
Does NiaCel really help with cognitive decline or Alzheimer's?
The evidence isn't established — we don't have enough reliable data to say whether nicotinamide riboside works for those conditions. It's marketed for them, but clinical research hasn't proven the benefit yet.
Is this supplement safe to take long-term?
Nicotinamide riboside appears well tolerated in short-term studies, but long-term safety isn't fully known. If you're thinking about taking it for months or years, talk with your doctor or pharmacist about what we do and don't know.
What's in the capsule besides the active ingredient?
The capsule contains hypromellose, microcrystalline cellulose, leucine, and silicon dioxide — these are inactive binders, thickeners, and fillers that hold the product together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NiaCel is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NiaCel label
Go deeper

The Full Monographs Behind NiaCel’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

NiaCel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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